The impact of a low‐carbohydrate (vs. low‐fat) diet on fat mass loss in African American women is modulated by insulin sensitivity
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Wiley
2025
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| author | Catia Martins David R. Bryan S. Katherine Sweatt W. Timothy Garvey Kevin R. Fontaine Gareth R. Dutton Barbara A. Gower |
| author_facet | Catia Martins David R. Bryan S. Katherine Sweatt W. Timothy Garvey Kevin R. Fontaine Gareth R. Dutton Barbara A. Gower Catia Martins David R. Bryan S. Katherine Sweatt W. Timothy Garvey Kevin R. Fontaine Gareth R. Dutton Barbara A. Gower |
| collection | Wiley Open Access |
| contents | The impact of a low‐carbohydrate (vs. low‐fat) diet on fat mass loss in African American women is modulated by insulin sensitivity Catia Martins David R. Bryan S. Katherine Sweatt W. Timothy Garvey Kevin R. Fontaine Gareth R. Dutton Barbara A. Gower Obesity AbstractObjectiveThe objective of this study was to examine the independent and interactive effects of insulin sensitivity (SI), the acute insulin response to glucose, and diet on changes in fat mass (FM), resting and total energy expenditure (REE and TEE, respectively), and mechanical efficiency, during weight loss, in African American women with obesity.MethodsA total of 69 women were randomized to low‐fat (55% carbohydrate [CHO], 20% fat) or low‐CHO (20% CHO, 55% fat) hypocaloric diets for 10 weeks, followed by a 4‐week weight‐stabilization period (controlled feeding). SI and acute insulin response to glucose were measured at baseline with an intravenous glucose tolerance test; body composition was measured with bioimpedance analysis at baseline and week 10; and REE, TEE, and mechanical efficiency were measured with indirect calorimetry, doubly labeled water, and a submaximal bike test, respectively, at baseline and week 14.ResultsWithin the group with low SI, those on the low‐CHO diet lost more weight (mean [SE], −6.6 [1.0] vs. −4.1 [1.4] kg; p = 0.076) and FM (−4.9 [0.9] vs. −2.1 [1.0] kg; p = 0.04) and experienced a lower reduction in REE (−48 [30] vs. −145 [30] kcal/day; p = 0.035) and TEE (mean [SE] 67 [56] vs. −230 [125] kcal/day; p = 0.009) compared with those on the low‐fat diet.ConclusionsA low‐CHO diet leads to a greater FM loss in African American women with obesity and low SI, likely by minimizing the reduction in EE that follows weight loss. 10.1002/oby.24201 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/oby.24201 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_oby_24201 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | The impact of a low‐carbohydrate (vs. low‐fat) diet on fat mass loss in African American women is modulated by insulin sensitivity Catia Martins David R. Bryan S. Katherine Sweatt W. Timothy Garvey Kevin R. Fontaine Gareth R. Dutton Barbara A. Gower Obesity The impact of a low‐carbohydrate (vs. low‐fat) diet on fat mass loss in African American women is modulated by insulin sensitivity Catia Martins David R. Bryan S. Katherine Sweatt W. Timothy Garvey Kevin R. Fontaine Gareth R. Dutton Barbara A. Gower Obesity AbstractObjectiveThe objective of this study was to examine the independent and interactive effects of insulin sensitivity (SI), the acute insulin response to glucose, and diet on changes in fat mass (FM), resting and total energy expenditure (REE and TEE, respectively), and mechanical efficiency, during weight loss, in African American women with obesity.MethodsA total of 69 women were randomized to low‐fat (55% carbohydrate [CHO], 20% fat) or low‐CHO (20% CHO, 55% fat) hypocaloric diets for 10 weeks, followed by a 4‐week weight‐stabilization period (controlled feeding). SI and acute insulin response to glucose were measured at baseline with an intravenous glucose tolerance test; body composition was measured with bioimpedance analysis at baseline and week 10; and REE, TEE, and mechanical efficiency were measured with indirect calorimetry, doubly labeled water, and a submaximal bike test, respectively, at baseline and week 14.ResultsWithin the group with low SI, those on the low‐CHO diet lost more weight (mean [SE], −6.6 [1.0] vs. −4.1 [1.4] kg; p = 0.076) and FM (−4.9 [0.9] vs. −2.1 [1.0] kg; p = 0.04) and experienced a lower reduction in REE (−48 [30] vs. −145 [30] kcal/day; p = 0.035) and TEE (mean [SE] 67 [56] vs. −230 [125] kcal/day; p = 0.009) compared with those on the low‐fat diet.ConclusionsA low‐CHO diet leads to a greater FM loss in African American women with obesity and low SI, likely by minimizing the reduction in EE that follows weight loss. 10.1002/oby.24201 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | The impact of a low‐carbohydrate (vs. low‐fat) diet on fat mass loss in African American women is modulated by insulin sensitivity |
| topic | Obesity |
| url | https://onlinelibrary.wiley.com/doi/10.1002/oby.24201 |