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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artículo Open Access |
| Pubblicazione: |
Wiley
2025
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| Soggetti: | |
| Accesso online: | https://onlinelibrary.wiley.com/doi/10.1002/oby.24248 |
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Sommario:
- Mapping the landscape of childhood obesity: genomic insights and socioeconomic status in Indian school‐going children Janaki M. Nair Ganesh Chauhan Gauri Prasad Khushdeep Bandesh Anil K. Giri Shraddha Chakraborty Raman K. Marwaha Sandeep Mathur Devapriya Choudhury Nikhil Tandon Analabha Basu Dwaipayan Bharadwaj Obesity AbstractObjectiveChildhood obesity (OB) is influenced by complex gene–environmental interaction. While genetics of adult OB have been extensively studied, polygenic childhood OB in non‐European populations is still underexplored. Furthermore, in a developing nation such as India, how the environmental component strongly modulated by the socioeconomic status (SES) shapes the genetic susceptibility is crucial to understand.MethodsA two‐staged genome‐wide association study (GWAS; N = 5673) and an independent exome‐wide association study (ExWAS; N = 4963) were performed using a generalized linear model assuming additive effect to identify the common and rare genetic variants respectively associated with childhood OB. Rare‐variant burden testing was also performed. We used the gene expression profiles and regulatory data from public databases to explain the novel associations. The implications of SES as a potential modifier of genetic susceptibility were evaluated.ResultsGWAS identified novel associations in TCF7L2, IMMP2L, IPMK, CDC5L, SNTG1, and MX1, whereas ExWAS uncovered CNTN4, COQ4, TNFRSF10D, FLG‐AS1, and BMP3. Both GWAS and ExWAS validated known associations in FTO and MC4R. Furthermore, rare‐variant testing highlighted the role of 101 genes. We also observed that SES can modulate the inherent susceptibility to OB.ConclusionsOur study identified genetic variants associated with childhood OB and highlighted the gene–environmental interaction in childhood OB. 10.1002/oby.24248 http://onlinelibrary.wiley.com/termsAndConditions#vor