Associations between coexposure to bisphenols mixture and metabolic diseases: based on three statistical models
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| Format: | Artículo Open Access |
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Wiley
2025
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| _version_ | 1867007240508014592 |
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| author | Yaqi Zhu Keqin Liu Jinjin Guo Yuqi Wang Jixin Yang Yanwei Su |
| author_facet | Yaqi Zhu Keqin Liu Jinjin Guo Yuqi Wang Jixin Yang Yanwei Su Yaqi Zhu Keqin Liu Jinjin Guo Yuqi Wang Jixin Yang Yanwei Su |
| collection | Wiley Open Access |
| contents | Associations between coexposure to bisphenols mixture and metabolic diseases: based on three statistical models Yaqi Zhu Keqin Liu Jinjin Guo Yuqi Wang Jixin Yang Yanwei Su Obesity AbstractIntroductionBisphenol A (BPA) and its substitutes are common environmental endocrine disruptors. We investigated whether coexposure to BPA and its substitutes are associated with metabolic diseases (MDs), the related indicators, and their multimorbidity.MethodsThe study included 1409 participants from the National Health and Nutrition Examination Survey (NHANES). Generalized linear regression, Bayesian kernel machine regression, and the weighted quantile sum (WQS) models were used to study the associations between bisphenol concentrations and comprehensive MDs, including their multimorbidity.ResultsIn the logistic regression model, BPA and bisphenol F were each independently associated with obesity, whereas BPA and bisphenol S (BPS) were each independently associated with multimorbidity. In the Bayesian kernel machine regression analysis, the joint effects of the three chemicals were positively associated with hypertension and obesity, with BPS generating the highest posterior inclusion probability. In the WQS regression analysis, the WQS index demonstrated significant associations with obesity and hypertension, with BPS the highest contributor to both of them.ConclusionsThree statistical methods confirmed that BPA and its substitutes were associated with specific MDs. Our findings indicate that coexposure to bisphenols significantly increases the risk of obesity and hypertension. 10.1002/oby.24327 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/oby.24327 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_oby_24327 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Associations between coexposure to bisphenols mixture and metabolic diseases: based on three statistical models Yaqi Zhu Keqin Liu Jinjin Guo Yuqi Wang Jixin Yang Yanwei Su Obesity Associations between coexposure to bisphenols mixture and metabolic diseases: based on three statistical models Yaqi Zhu Keqin Liu Jinjin Guo Yuqi Wang Jixin Yang Yanwei Su Obesity AbstractIntroductionBisphenol A (BPA) and its substitutes are common environmental endocrine disruptors. We investigated whether coexposure to BPA and its substitutes are associated with metabolic diseases (MDs), the related indicators, and their multimorbidity.MethodsThe study included 1409 participants from the National Health and Nutrition Examination Survey (NHANES). Generalized linear regression, Bayesian kernel machine regression, and the weighted quantile sum (WQS) models were used to study the associations between bisphenol concentrations and comprehensive MDs, including their multimorbidity.ResultsIn the logistic regression model, BPA and bisphenol F were each independently associated with obesity, whereas BPA and bisphenol S (BPS) were each independently associated with multimorbidity. In the Bayesian kernel machine regression analysis, the joint effects of the three chemicals were positively associated with hypertension and obesity, with BPS generating the highest posterior inclusion probability. In the WQS regression analysis, the WQS index demonstrated significant associations with obesity and hypertension, with BPS the highest contributor to both of them.ConclusionsThree statistical methods confirmed that BPA and its substitutes were associated with specific MDs. Our findings indicate that coexposure to bisphenols significantly increases the risk of obesity and hypertension. 10.1002/oby.24327 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Associations between coexposure to bisphenols mixture and metabolic diseases: based on three statistical models |
| topic | Obesity |
| url | https://onlinelibrary.wiley.com/doi/10.1002/oby.24327 |