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| Main Authors: | , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2025
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| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/oby.24344 |
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Table of Contents:
- Breastfeeding, genetic susceptibility, and type 2 diabetes in offspring in later life Ying Hu Hao Ma Xuan Wang Shuqi Zhu Danqing Chen Zhaoxia Liang Obesity Abstract Objective Our objective was to assess the prospective association between breastfeeding and the risk of type 2 diabetes (T2D) in offspring and to investigate the joint effects of breastfeeding and genetic susceptibility on T2D risk. Methods We included 364,562 participants free from prevalent T2D from the UK Biobank. Cox proportional hazards models were employed to evaluate the association between breastfeeding and incident T2D. Results Over a median follow‐up of 12 years, 12,795 cases of incident T2D were recorded. Ever breastfeeding was associated with a significantly lower risk of T2D compared with never breastfeeding (hazard ratio = 0.94, 95% CI: 0.89–0.99). Additionally, significant interaction effects on T2D risk were observed between breastfeeding and T2D genetic risk score (T2D‐GRS), both multiplicatively and additively. The association between T2D‐GRS and risk of T2D was stronger in participants who were never breastfed compared with those who were breastfed ( p for multiplicative interaction = 0.040). The risk of T2D associated with never breastfeeding combined with a high T2D‐GRS was greater than the sum of the risks associated with each individual factor ( p for additive interaction = 0.007). Conclusions Breastfeeding is associated with a lower risk of incident T2D in offspring, showing both multiplicative and additive interactions with T2D‐GRS. 10.1002/oby.24344 http://creativecommons.org/licenses/by-nc-nd/4.0/