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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artículo Open Access |
| Pubblicazione: |
Wiley
2025
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| Soggetti: | |
| Accesso online: | https://onlinelibrary.wiley.com/doi/10.1002/oby.70000 |
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Sommario:
- Placental Gene Expression Associated With Early Childhood Growth Trajectories and Obesity Risk Hyo Young Choi Luhang Han Alison G. Paquette James MacDonald Theo Bammler Christine Loftus Daniel A. Enquobahrie Kaja Z. LeWinn Nicole R. Bush Catherine J. Karr Sheela Sathyanarayana Qi Zhao Obesity ABSTRACT Objective This study aimed to investigate the association of placental gene expression with early childhood growth trajectories and obesity risk. Methods We analyzed 794 children from the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study. Placental samples collected at delivery underwent RNA sequencing to obtain transcriptome data. BMI trajectories from birth to 4 years (rising‐high‐, moderate‐, and low‐BMI) and overweight/obesity at 4 years were the childhood outcomes of interest. Differentially expressed genes (DEGs) associated with the outcomes were identified using DESeq2. Pathway enrichment analysis was performed on DEGs. Their causal relationships with outcomes were explored using the Mendelian randomization (MR) approach. Results We identified 22 and 23 DEGs associated with BMI trajectories and overweight/obesity, respectively, with false discovery rates (FDR) < 0.05. Pathway analysis of these DEGs identified 26 biological pathways, primarily related to the immune system. MR analysis suggested that one ( SSX2B ) and eight DEGs (e.g., HSPA1A , DNAJB1 ) might be causally associated with the BMI trajectories and overweight/obesity (FDR < 0.05), respectively. Conclusions This study identified placental gene expression associated with early childhood growth outcomes. These findings suggest the potential important role of placental immune system genes in the development of childhood obesity. 10.1002/oby.70000 http://onlinelibrary.wiley.com/termsAndConditions#vor