Grandmaternal Obesity and Risks of Birth Asphyxia‐Related Complications in Grand‐Offspring: A Countrywide Three‐Generation Study
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Wiley
2025
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| author | Eduardo Villamor Amanda K. Miglin Sven Cnattingius |
| author_facet | Eduardo Villamor Amanda K. Miglin Sven Cnattingius Eduardo Villamor Amanda K. Miglin Sven Cnattingius |
| collection | Wiley Open Access |
| contents | Grandmaternal Obesity and Risks of Birth Asphyxia‐Related Complications in Grand‐Offspring: A Countrywide Three‐Generation Study Eduardo Villamor Amanda K. Miglin Sven Cnattingius Obesity ABSTRACT Objective We investigated the associations of grandmaternal early pregnancy BMI with grand‐offspring risks of birth asphyxia‐related complications. Methods In a nationwide three‐generation Swedish cohort, we estimated adjusted relative risks (RRs) of Apgar score 0–3 at 5 min and neonatal seizures for categories of grandmaternal BMI among 315,461 maternal and 203,522 paternal singleton live‐born grand‐offspring. To address unmeasured confounding by shared familial factors, we used the parental full sisters' BMI as a negative control exposure. In the maternal line, we assessed whether associations with grandmaternal obesity were mediated through maternal obesity. Results Compared with normal maternal grandmaternal BMI, RRs (95% CI) of low Apgar score were, respectively, 1.29 (1.06, 1.57) and 1.53 (1.03, 2.28) for overweight (BMI 25.0 to 29.9) and obesity (BMI ≥ 30.0). For neonatal seizures, the corresponding RRs (95% CI) were 1.32 (1.05, 1.66) and 1.81 (1.17, 2.79). Maternal sisters' BMI was unrelated to both outcomes. Maternal obesity mediated < 25% of the associations with maternal grandmaternal obesity. Paternal grandmaternal obesity was related to an increased risk of neonatal seizures; paternal sisters' BMI was unrelated to this outcome. Conclusions Grandmaternal overweight and obesity are related to increased risks of severe birth asphyxia‐related complications in grand‐offspring, independent of unmeasured shared familial factors. 10.1002/oby.70046 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/oby.70046 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_oby_70046 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Grandmaternal Obesity and Risks of Birth Asphyxia‐Related Complications in Grand‐Offspring: A Countrywide Three‐Generation Study Eduardo Villamor Amanda K. Miglin Sven Cnattingius Obesity Grandmaternal Obesity and Risks of Birth Asphyxia‐Related Complications in Grand‐Offspring: A Countrywide Three‐Generation Study Eduardo Villamor Amanda K. Miglin Sven Cnattingius Obesity ABSTRACT Objective We investigated the associations of grandmaternal early pregnancy BMI with grand‐offspring risks of birth asphyxia‐related complications. Methods In a nationwide three‐generation Swedish cohort, we estimated adjusted relative risks (RRs) of Apgar score 0–3 at 5 min and neonatal seizures for categories of grandmaternal BMI among 315,461 maternal and 203,522 paternal singleton live‐born grand‐offspring. To address unmeasured confounding by shared familial factors, we used the parental full sisters' BMI as a negative control exposure. In the maternal line, we assessed whether associations with grandmaternal obesity were mediated through maternal obesity. Results Compared with normal maternal grandmaternal BMI, RRs (95% CI) of low Apgar score were, respectively, 1.29 (1.06, 1.57) and 1.53 (1.03, 2.28) for overweight (BMI 25.0 to 29.9) and obesity (BMI ≥ 30.0). For neonatal seizures, the corresponding RRs (95% CI) were 1.32 (1.05, 1.66) and 1.81 (1.17, 2.79). Maternal sisters' BMI was unrelated to both outcomes. Maternal obesity mediated < 25% of the associations with maternal grandmaternal obesity. Paternal grandmaternal obesity was related to an increased risk of neonatal seizures; paternal sisters' BMI was unrelated to this outcome. Conclusions Grandmaternal overweight and obesity are related to increased risks of severe birth asphyxia‐related complications in grand‐offspring, independent of unmeasured shared familial factors. 10.1002/oby.70046 http://creativecommons.org/licenses/by/4.0/ |
| title | Grandmaternal Obesity and Risks of Birth Asphyxia‐Related Complications in Grand‐Offspring: A Countrywide Three‐Generation Study |
| topic | Obesity |
| url | https://onlinelibrary.wiley.com/doi/10.1002/oby.70046 |