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| Main Authors: | , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2025
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| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/oby.70049 |
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Table of Contents:
- Glucose‐Dependent Insulinotropic Polypeptide and Glucagon After Weight Loss Induced by Diet or Bariatric Surgery Amanda Finn Yenni Cedillo Marthe Aukan Barbara Gower Catia Martins Obesity ABSTRACT Objective This study compared the effects of a very low‐energy diet (VLED), alone or combined with sleeve gastrectomy (SG) or Roux‐en‐Y gastric bypass (RYGB), on glucose‐dependent insulinotropic polypeptide (GIP) and glucagon concentrations, hormones likely to play a role in weight loss maintenance. Methods Participants with severe obesity underwent 10 weeks of VLED alone ( n = 15) or combined with SG ( n = 15) or RYGB ( n = 14). Plasma concentrations of glucagon and GIP (fasting and the first 60 min of a meal), insulin sensitivity, respiratory quotient, and resting energy expenditure (REE) were measured at pre‐ and post‐intervention. Differences in hormone concentrations between groups at follow‐up and associations between hormones and metabolic outcomes were evaluated. Results Fasting glucagon concentrations were higher, while postprandial GIP concentrations were lower, after RYGB compared to SG. An increase in postprandial glucagon was associated with a decrease in Matsuda index in the RYGB group and with an increase in REE in all groups. An increase in fasting GIP was correlated with an increase in HOMA‐IR. Conclusions RYGB was associated with lower postprandial GIP and greater glucagon concentrations compared with other groups. These hormonal changes are likely to impact REE, as well as insulin sensitivity, potentially modulating the likelihood of weight loss maintenance. Trial Registration: ClinicalTrials.gov identifier NCT04051190. 10.1002/oby.70049 http://creativecommons.org/licenses/by-nc/4.0/