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| Main Authors: | , , , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2026
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/oby.70163 |
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Table of Contents:
- Real‐World Weight Loss Is Associated With a Reduction in Cancer Risk Kenda Alkwatli Huijun Xiao Arshiya Mariam‐Smith Nerea Lopetegui Marcio L. Griebeler Bartolome Burguera Kevin M. Pantalone Daniel M. Rotroff Obesity ABSTRACT Objective Obesity is a major risk factor for multiple cancers, yet the impact of nonsurgical weight loss on cancer risk remains uncertain. Our objective was to evaluate whether real‐world nonsurgical weight loss is associated with a reduced risk of developing cancer. Methods We conducted a retrospective observational study of 143,630 adults (BMI ≥ 30) from an integrated US health system's electronic health records (2000–2022). Cases with incident cancer were compared to matched controls. Using generalized linear models with a logit link, we assessed whether BMI change over 3‐, 5‐, and 10‐year intervals is associated with the risk of diagnosis for obesity‐related and other cancers. Results Among 143,630 patients, 7703 cases and 135,927 controls were identified. Each 1% BMI reduction was linked to lower obesity‐related cancer risk at 3 years (OR, 0.990; 95% CI, 0.984–0.996; p < 0.001), 5 years (OR, 0.989; 95% CI, 0.984–0.995; p < 0.001), and 10 years (OR, 0.992; 95% CI, 0.984–1.000; p = 0.057). Similar associations were observed for other cancer types across all intervals (OR < 1; p < 0.001). Conclusions Real‐world weight loss was associated with a decreased risk of obesity‐related and other cancers. 10.1002/oby.70163 http://creativecommons.org/licenses/by/4.0/