Associations Between Gestational Weight Gain and Children's Neurodevelopment at 3 Years of Age
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| Format: | Artículo Open Access |
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Wiley
2026
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| author | Yongbin Xiong Yangqian Jiang Wenjing Chang Ganchong Liao Rui Qin Hong Lv Cong Liu Xin Xu Lei You Tianyu Sun Yuanyan Dou Bo Xu Xiumei Han Xiaoyu Liu Kun Zhou Hongxia Ma Zhibin Hu Kan Ye Yuan Lin |
| author_facet | Yongbin Xiong Yangqian Jiang Wenjing Chang Ganchong Liao Rui Qin Hong Lv Cong Liu Xin Xu Lei You Tianyu Sun Yuanyan Dou Bo Xu Xiumei Han Xiaoyu Liu Kun Zhou Hongxia Ma Zhibin Hu Kan Ye Yuan Lin Yongbin Xiong Yangqian Jiang Wenjing Chang Ganchong Liao Rui Qin Hong Lv Cong Liu Xin Xu Lei You Tianyu Sun Yuanyan Dou Bo Xu Xiumei Han Xiaoyu Liu Kun Zhou Hongxia Ma Zhibin Hu Kan Ye Yuan Lin |
| collection | Wiley Open Access |
| contents | Associations Between Gestational Weight Gain and Children's Neurodevelopment at 3 Years of Age Yongbin Xiong Yangqian Jiang Wenjing Chang Ganchong Liao Rui Qin Hong Lv Cong Liu Xin Xu Lei You Tianyu Sun Yuanyan Dou Bo Xu Xiumei Han Xiaoyu Liu Kun Zhou Hongxia Ma Zhibin Hu Kan Ye Yuan Lin Obesity ABSTRACT Objective This study aimed to investigate the associations of gestational weight gain (GWG) and GWG trajectory with children's neurodevelopment at age three. Methods This prospective analysis included 4177 mother–child pairs from the Jiangsu Birth Cohort. GWG was assessed both as categories (insufficient/optimal/excessive) and trajectories based on repeated prenatal measurements. Children's neurodevelopment at age three was assessed using the Bayley Scales of Infant and Toddler Development, Version‐III Screening Test. A Robust Poisson regression model was used to examine the associations of GWG categories and trajectories with children's neurodevelopment. Results Compared with children of mothers with optimal GWG, those exposed to excessive GWG had 50% higher noncompetent cognitive risk (RR = 1.50), while insufficient GWG increased noncompetent fine motor risk by 30% (RR = 1.30). Notably, the association between insufficient GWG and noncompetent cognitive development was observed only among those with breastfeeding duration ≤ 12 months (RR = 2.07), not among those breastfeeding > 12 months (RR = 0.72). The “Slow‐Rapid” GWG trajectory was associated with elevated risks of both noncompetent cognitive development (RR = 2.51) and expressive communication (RR = 1.94). Conclusions Excessive GWG, insufficient GWG, and the Slow‐Rapid GWG trajectory showed associations with children's noncompetent neurodevelopment. As GWG is a modifiable factor, these findings could inform early intervention for high‐risk mother–child dyads. 10.1002/oby.70192 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/oby.70192 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_oby_70192 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Associations Between Gestational Weight Gain and Children's Neurodevelopment at 3 Years of Age Yongbin Xiong Yangqian Jiang Wenjing Chang Ganchong Liao Rui Qin Hong Lv Cong Liu Xin Xu Lei You Tianyu Sun Yuanyan Dou Bo Xu Xiumei Han Xiaoyu Liu Kun Zhou Hongxia Ma Zhibin Hu Kan Ye Yuan Lin Obesity Associations Between Gestational Weight Gain and Children's Neurodevelopment at 3 Years of Age Yongbin Xiong Yangqian Jiang Wenjing Chang Ganchong Liao Rui Qin Hong Lv Cong Liu Xin Xu Lei You Tianyu Sun Yuanyan Dou Bo Xu Xiumei Han Xiaoyu Liu Kun Zhou Hongxia Ma Zhibin Hu Kan Ye Yuan Lin Obesity ABSTRACT Objective This study aimed to investigate the associations of gestational weight gain (GWG) and GWG trajectory with children's neurodevelopment at age three. Methods This prospective analysis included 4177 mother–child pairs from the Jiangsu Birth Cohort. GWG was assessed both as categories (insufficient/optimal/excessive) and trajectories based on repeated prenatal measurements. Children's neurodevelopment at age three was assessed using the Bayley Scales of Infant and Toddler Development, Version‐III Screening Test. A Robust Poisson regression model was used to examine the associations of GWG categories and trajectories with children's neurodevelopment. Results Compared with children of mothers with optimal GWG, those exposed to excessive GWG had 50% higher noncompetent cognitive risk (RR = 1.50), while insufficient GWG increased noncompetent fine motor risk by 30% (RR = 1.30). Notably, the association between insufficient GWG and noncompetent cognitive development was observed only among those with breastfeeding duration ≤ 12 months (RR = 2.07), not among those breastfeeding > 12 months (RR = 0.72). The “Slow‐Rapid” GWG trajectory was associated with elevated risks of both noncompetent cognitive development (RR = 2.51) and expressive communication (RR = 1.94). Conclusions Excessive GWG, insufficient GWG, and the Slow‐Rapid GWG trajectory showed associations with children's noncompetent neurodevelopment. As GWG is a modifiable factor, these findings could inform early intervention for high‐risk mother–child dyads. 10.1002/oby.70192 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Associations Between Gestational Weight Gain and Children's Neurodevelopment at 3 Years of Age |
| topic | Obesity |
| url | https://onlinelibrary.wiley.com/doi/10.1002/oby.70192 |