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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Format: | Artículo Open Access |
| Veröffentlicht: |
Wiley
2026
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| Online-Zugang: | https://onlinelibrary.wiley.com/doi/10.1002/oby.70207 |
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Inhaltsangabe:
- Effects of Time‐Restricted Eating on Gut Microbiota and Metabolites and Their Relationship With Cardiometabolic Risk Factors Li‐Min Zhang Zi‐Dan Wang Zheng Zhang Jie Liu Zhi‐Hao Li Yue‐Rong Ren Zhan Liu Xiao Zhang Xian‐Yun Wang Ke‐Xin Qi Chang Yuan Hao Guo Yi‐Fei Zhang Jun Ge Yu‐Xia Ma Obesity ABSTRACT Objective This study aimed to investigate whether the time of the eating window during time‐restricted eating (TRE) alters the gut microbiota and metabolomic profiles and to determine their relationship with cardiometabolic risk factors in adults with overweight or obesity. Methods In an 8‐week randomized controlled trial, 60 young adults with overweight or obesity were randomized to 6‐h eTRE (7 a.m.–1 p.m.), 6‐h lTRE (12 p.m.–6 p.m.), or a control group (ad libitum). The gut microbiota was analyzed by 16S ribosomal RNA (16S rRNA) sequencing and serum metabolomics were quantified by liquid chromatography‐mass spectrometry (LC–MS). Results After 8 weeks, compared to the control group, the 6‐h eTRE increased abundance of Faecalibacterium and Lactobacillus and decreased abundance of unclassified_f_Peptostreptococcaceae, whereas 6‐h lTRE significantly increased abundance of Faecalibacterium and decreased abundance of Shigella (all p < 0.05). Differential serum metabolites (e.g., L‐malic acid in eTRE; isovaleric acid in lTRE) were significantly associated with changes in weight, body fat, and systolic blood pressure (SBP) ( p < 0.05). Conclusions Time‐restricted eating may be beneficial to weight loss and cardiometabolic health improvement by regulating gut microbiota and serum metabolites. Trial Registration: Chinese Clinical Trial Registry ChiCTR2000039115. image 10.1002/oby.70207 http://onlinelibrary.wiley.com/termsAndConditions#vor