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| Main Authors: | , , , , |
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| Format: | Artículo Open Access |
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Wiley
2024
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| Online Access: | https://aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1002/ohn.1108 |
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Table of Contents:
- Human Papilloma Virus Infection and Sinonasal Inverted Papilloma Recurrence: A Meta‐Analysis Fayssal Alqudrah Sharwani Kota Jason Morgan Phillip R. Purnell Justin P. McCormick Otolaryngology–Head and Neck Surgery AbstractObjectivePrior studies have been contradictory on the role of human papillomavirus (HPV) infection in sinonasal inverted papilloma (SNIP) recurrence. This systematic review and meta‐analysis was performed to further evaluate this potential association.Data SourcesPubMed, Embase, and Scopus electronic databases.Review MethodsCase‐control studies reporting SNIP recurrence data and HPV status identified by polymerase chain reaction (PCR) and in‐situ hybridization (ISH). Meta‐analysis was performed to determine pooled odds ratios (ORs) and 95% confidence intervals (CI).Results25 studies were identified including a total of 1116 benign SNIP tumors. A total of 267 SNIP were HPV+, 103 of which were recurrent, and 849 SNIP were HPV−, with 231 being recurrent. The pooled standard OR for recurrence in HPV+ tumors was 2.05 (95% CI: 1.31‐3.19). Stratification by low‐risk and high‐risk HPV subtypes were not statistically significant. The standard OR for SNIP recurrence in low‐risk and high‐risk HPV+ subtypes were 1.57 (95% CI: 0.98‐2.54) and 1.67 (95% CI: 0.98‐2.80), respectively.ConclusionInfection with HPV may be associated with an increased risk of SNIP recurrence. This increased risk seems to be independent of HPV subtype based on low‐risk or high‐risk status. However, this correlation was variable among recently published studies requiring additional investigation. 10.1002/ohn.1108 http://creativecommons.org/licenses/by/4.0/