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| Main Authors: | , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2026
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| Subjects: | |
| Online Access: | https://aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1002/ohn.70276 |
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Table of Contents:
- Irreversible Electroporation for Tonsillar Ablation in Adults Codrut Sarafoleanu Ionut Tanase Mihai Alexandru Pascu Desiderio Passali Ari DeRowe Otolaryngology–Head and Neck Surgery Abstract Objective To evaluate the safety and efficacy of irreversible electroporation for non‐thermal ablation of tonsils in adults. Study Design Prospective interventional case series of 24 adult patients referred for tonsillectomy that were followed for 3 months. Setting Academic medical center. Methods The procedures were performed under general anesthesia or sedation. Irreversible electroporation was applied to the tonsils using the ENTire TM system. Pain was assessed daily using a pain scale for the first postoperative week. Tonsil sizes were assessed at baseline and 1 and 3 months postoperatively. The Tonsil and Adenoid Health Status Instrument and the Snore‐Visual Analog Scale (VAS) questionnaires were administered at baseline and at 3 months. Results In total, 23 adult patients (mean age: 36.5 ± 14.0; mean body mass index [BMI]: 25.5 ± 4.1) completed the study. No bleeding was observed intra‐ or postoperatively. Procedural time was 7.98 ± 2.62 minutes. A pain scale score below 2 was reported 4.5 ± 1.7 days after intervention. Reduction in tonsillar size was observed from 2.4 ± 0.9 pre‐intervention to 1.3 ± 1.0 at 3 months post‐intervention ( P < .001). Tonsil and Adenoid Health Status scores decreased from 17.7 ± 13.0 to 0.96 ± 1.7 ( P < .001). The Snore‐ VAS score decreased by 72%. Conclusion This is the first clinical study to investigate the use of irreversible electroporation for tonsillar ablation. Irreversible electroporation shows promise as a minimally invasive procedure for reducing the size of tonsillar hypertrophy and alleviating symptoms, with negligible bleeding and significantly less pain. Multicenter studies are in progress to evaluate long‐term efficacy including in children. 10.1002/ohn.70276 http://creativecommons.org/licenses/by/4.0/