Impact of Reduced Acidic Earwax pH and Earwax‐Determinant Genotypes in Acquired Middle Ear Cholesteatoma
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Wiley
2024
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| author | Satoshi Hara Takeshi Kusunoki Hiroshi Nakagawa Kazusaku Kamiya Yu Toyoda Yusuke Takata Takashi Anzai Masayuki Furukawa Hiroko Okada Takumi Nakayama Katsuhisa Ikeda Fumihiko Matsumoto |
| author_facet | Satoshi Hara Takeshi Kusunoki Hiroshi Nakagawa Kazusaku Kamiya Yu Toyoda Yusuke Takata Takashi Anzai Masayuki Furukawa Hiroko Okada Takumi Nakayama Katsuhisa Ikeda Fumihiko Matsumoto Satoshi Hara Takeshi Kusunoki Hiroshi Nakagawa Kazusaku Kamiya Yu Toyoda Yusuke Takata Takashi Anzai Masayuki Furukawa Hiroko Okada Takumi Nakayama Katsuhisa Ikeda Fumihiko Matsumoto |
| collection | Wiley Open Access |
| contents | Impact of Reduced Acidic Earwax pH and Earwax‐Determinant Genotypes in Acquired Middle Ear Cholesteatoma Satoshi Hara Takeshi Kusunoki Hiroshi Nakagawa Kazusaku Kamiya Yu Toyoda Yusuke Takata Takashi Anzai Masayuki Furukawa Hiroko Okada Takumi Nakayama Katsuhisa Ikeda Fumihiko Matsumoto Otolaryngology–Head and Neck Surgery Abstract Objective The development of acquired middle ear cholesteatoma is associated with a single nucleotide polymorphism, 538G>A, in the human adenosine triphosphate‐binding cassette transporter C11 ( ABCC11 ) gene, which is a determinant of the earwax morphotype, such as wet‐ and dry‐type earwax; however, the mechanism underlying this association is unclear. We focused on the earwax pH and aimed to elucidate the mechanism between ABCC11 genotypes and acquired middle ear cholesteatoma. Study Design Prospective observational study. Setting Single‐center, academic hospital. Methods We recruited 40 patients with acquired middle ear cholesteatoma who underwent surgery and 115 controls with no history of middle ear cholesteatoma. We assessed the earwax pH and ABCC11 genotypes in all participants. Clinical information was collected from the patients with cholesteatoma. Results The earwax pH was significantly less acidic in patients with cholesteatoma and those carrying wet earwax genotypes ( ABCC11 538G/G or 538G/A) than in the controls and those carrying the dry earwax genotype ( ABCC11 538A/A), respectively. Furthermore, earwax pH was significantly positively correlated with high preoperative cholesteatoma stages in the patients with cholesteatoma. Conclusion Our results show that the less acidic earwax pH was significantly related to the development and progression of acquired middle ear cholesteatoma. The less acidic earwax pH may play an important role in the mechanism underlying the association between acquired middle ear cholesteatoma and the ABCC11 gene at site 538. 10.1002/ohn.888 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/ohn.888 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ohn_888 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Impact of Reduced Acidic Earwax pH and Earwax‐Determinant Genotypes in Acquired Middle Ear Cholesteatoma Satoshi Hara Takeshi Kusunoki Hiroshi Nakagawa Kazusaku Kamiya Yu Toyoda Yusuke Takata Takashi Anzai Masayuki Furukawa Hiroko Okada Takumi Nakayama Katsuhisa Ikeda Fumihiko Matsumoto Otolaryngology–Head and Neck Surgery Impact of Reduced Acidic Earwax pH and Earwax‐Determinant Genotypes in Acquired Middle Ear Cholesteatoma Satoshi Hara Takeshi Kusunoki Hiroshi Nakagawa Kazusaku Kamiya Yu Toyoda Yusuke Takata Takashi Anzai Masayuki Furukawa Hiroko Okada Takumi Nakayama Katsuhisa Ikeda Fumihiko Matsumoto Otolaryngology–Head and Neck Surgery Abstract Objective The development of acquired middle ear cholesteatoma is associated with a single nucleotide polymorphism, 538G>A, in the human adenosine triphosphate‐binding cassette transporter C11 ( ABCC11 ) gene, which is a determinant of the earwax morphotype, such as wet‐ and dry‐type earwax; however, the mechanism underlying this association is unclear. We focused on the earwax pH and aimed to elucidate the mechanism between ABCC11 genotypes and acquired middle ear cholesteatoma. Study Design Prospective observational study. Setting Single‐center, academic hospital. Methods We recruited 40 patients with acquired middle ear cholesteatoma who underwent surgery and 115 controls with no history of middle ear cholesteatoma. We assessed the earwax pH and ABCC11 genotypes in all participants. Clinical information was collected from the patients with cholesteatoma. Results The earwax pH was significantly less acidic in patients with cholesteatoma and those carrying wet earwax genotypes ( ABCC11 538G/G or 538G/A) than in the controls and those carrying the dry earwax genotype ( ABCC11 538A/A), respectively. Furthermore, earwax pH was significantly positively correlated with high preoperative cholesteatoma stages in the patients with cholesteatoma. Conclusion Our results show that the less acidic earwax pH was significantly related to the development and progression of acquired middle ear cholesteatoma. The less acidic earwax pH may play an important role in the mechanism underlying the association between acquired middle ear cholesteatoma and the ABCC11 gene at site 538. 10.1002/ohn.888 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Impact of Reduced Acidic Earwax pH and Earwax‐Determinant Genotypes in Acquired Middle Ear Cholesteatoma |
| topic | Otolaryngology–Head and Neck Surgery |
| url | https://aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1002/ohn.888 |