A Stepwise Approach to 1,4,10,13‐Tetraaza‐18‐Crown‐6 Ether
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Wiley Open Access
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| Format: | Artículo Open Access |
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Wiley
2026
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| _version_ | 1867015010901819392 |
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| author | Pieter Troosters Lara Bruneel Wim Dehaen Tomas Opsomer |
| author_facet | Pieter Troosters Lara Bruneel Wim Dehaen Tomas Opsomer Pieter Troosters Lara Bruneel Wim Dehaen Tomas Opsomer |
| collection | Wiley Open Access |
| contents | A Stepwise Approach to 1,4,10,13‐Tetraaza‐18‐Crown‐6 Ether Pieter Troosters Lara Bruneel Wim Dehaen Tomas Opsomer ChemistryOpen A two‐step approach to the synthesis of tetraaza‐18‐crown‐6 ether was evaluated to address the limitations of the currently used one‐step macrocyclization, such as low yield due to substantial side product formation. In this route, the reaction conditions were optimized, reducing cyclization to the undesired nine‐membered ring by a factor of eight. This resulted in a 50% yield for the two‐step macrocyclization, or 28% when column chromatography was avoided, both significantly higher than the 16% yield obtained when reproducing the one‐step method. 10.1002/open.70201 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/open.70201 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_open_70201 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | A Stepwise Approach to 1,4,10,13‐Tetraaza‐18‐Crown‐6 Ether Pieter Troosters Lara Bruneel Wim Dehaen Tomas Opsomer ChemistryOpen A Stepwise Approach to 1,4,10,13‐Tetraaza‐18‐Crown‐6 Ether Pieter Troosters Lara Bruneel Wim Dehaen Tomas Opsomer ChemistryOpen A two‐step approach to the synthesis of tetraaza‐18‐crown‐6 ether was evaluated to address the limitations of the currently used one‐step macrocyclization, such as low yield due to substantial side product formation. In this route, the reaction conditions were optimized, reducing cyclization to the undesired nine‐membered ring by a factor of eight. This resulted in a 50% yield for the two‐step macrocyclization, or 28% when column chromatography was avoided, both significantly higher than the 16% yield obtained when reproducing the one‐step method. 10.1002/open.70201 http://creativecommons.org/licenses/by/4.0/ |
| title | A Stepwise Approach to 1,4,10,13‐Tetraaza‐18‐Crown‐6 Ether |
| topic | ChemistryOpen |
| url | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.70201 |