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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2024
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| Online Access: | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6238 |
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Table of Contents:
- Image‐based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno‐oncology Biomarker Working Group on Breast Cancer Chowdhury Arif Jahangir David B Page Glenn Broeckx Claudia A Gonzalez Caoimbhe Burke Clodagh Murphy Jorge S Reis‐Filho Amy Ly Paul W Harms Rajarsi R Gupta Michael Vieth Akira I Hida Mohamed Kahila Zuzana Kos Paul J van Diest Sara Verbandt Jeppe Thagaard Reena Khiroya Khalid Abduljabbar Gabriela Acosta Haab Balazs Acs Sylvia Adams Jonas S Almeida Isabel Alvarado‐Cabrero Farid Azmoudeh‐Ardalan Sunil Badve Nurkhairul Bariyah Baharun Enrique R Bellolio Vydehi Bheemaraju Kim RM Blenman Luciana Botinelly Mendonça Fujimoto Octavio Burgues Alexandros Chardas Maggie Chon U Cheang Francesco Ciompi Lee AD Cooper An Coosemans Germán Corredor Flavio Luis Dantas Portela Frederik Deman Sandra Demaria Sarah N Dudgeon Mahmoud Elghazawy Claudio Fernandez‐Martín Susan Fineberg Stephen B Fox Jennifer M Giltnane Sacha Gnjatic Paula I Gonzalez‐Ericsson Anita Grigoriadis Niels Halama Matthew G Hanna Aparna Harbhajanka Steven N Hart Johan Hartman Stephen Hewitt Hugo M Horlings Zaheed Husain Sheeba Irshad Emiel AM Janssen Tatsuki R Kataoka Kosuke Kawaguchi Andrey I Khramtsov Umay Kiraz Pawan Kirtani Liudmila L Kodach Konstanty Korski Guray Akturk Ely Scott Anikó Kovács Anne‐Vibeke Lænkholm Corinna Lang‐Schwarz Denis Larsimont Jochen K Lennerz Marvin Lerousseau Xiaoxian Li Anant Madabhushi Sai K Maley Vidya Manur Narasimhamurthy Douglas K Marks Elizabeth S McDonald Ravi Mehrotra Stefan Michiels Durga Kharidehal Fayyaz ul Amir Afsar Minhas Shachi Mittal David A Moore Shamim Mushtaq Hussain Nighat Thomas Papathomas Frederique Penault‐Llorca Rashindrie D Perera Christopher J Pinard Juan Carlos Pinto‐Cardenas Giancarlo Pruneri Lajos Pusztai Nasir Mahmood Rajpoot Bernardo Leon Rapoport Tilman T Rau Joana M Ribeiro David Rimm Anne Vincent‐Salomon Joel Saltz Shahin Sayed Evangelos Hytopoulos Sarah Mahon Kalliopi P Siziopikou Christos Sotiriou Albrecht Stenzinger Maher A Sughayer Daniel Sur Fraser Symmans Sunao Tanaka Timothy Taxter Sabine Tejpar Jonas Teuwen E Aubrey Thompson Trine Tramm William T Tran Jeroen van der Laak Gregory E Verghese Giuseppe Viale Noorul Wahab Thomas Walter Yannick Waumans Hannah Y Wen Wentao Yang Yinyin Yuan John Bartlett Sibylle Loibl Carsten Denkert Peter Savas Sherene Loi Elisabeth Specht Stovgaard Roberto Salgado William M Gallagher Arman Rahman The Journal of Pathology Abstract Recent advances in the field of immuno‐oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high‐throughput multiplex immunophenotyping of tumour samples has great potential to guide appropriate treatment choices. Moreover, the emergence of novel multi‐marker imaging approaches can now provide unprecedented insights into the tumour microenvironment, including the potential interplay between various cell types. However, there are significant challenges to widespread integration of these technologies in daily research and clinical practice. This review addresses the challenges and potential solutions within a structured framework of action from a regulatory and clinical trial perspective. New developments within the field of immunophenotyping using multiplexed tissue imaging platforms and associated digital pathology are also described, with a specific focus on translational implications across different subtypes of cancer. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 10.1002/path.6238 http://creativecommons.org/licenses/by-nc-nd/4.0/