Beyond driver mutations: exploring the landscape of mutational signatures in adenocarcinomas of the bladder†
Fuente:
Wiley Open Access
Enregistré dans:
| Auteurs principaux: | , |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2024
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1867017381884198914 |
|---|---|
| author | Tibor Szarvas Henning Reis |
| author_facet | Tibor Szarvas Henning Reis Tibor Szarvas Henning Reis |
| collection | Wiley Open Access |
| contents | Beyond driver mutations: exploring the landscape of mutational signatures in adenocarcinomas of the bladder† Tibor Szarvas Henning Reis The Journal of Pathology AbstractThe emergence of mutational signatures in cancer research represents a paradigm shift, offering profound insights into tumor biology, therapeutic strategies, and risk assessment. A recent article published in The Journal of Pathology delves into the significance of mutational signatures, assessing their role as molecular fingerprints that illuminate the etiology of individual cancer cases. By deciphering the diverse patterns of DNA alterations, in the context of urachal and nonurachal bladder adenocarcinomas, researchers can unravel intrinsic and environmental risk factors shaping cancer development. The study highlighted a predominance of environmental risk factors in Chinese populations affected by bladder adenocarcinomas. In this context, in this commentary, we highlight some of the potential applications of molecular signatures in differential diagnosis and therapy prediction. As the field continues to evolve, a deeper understanding of mutational signatures promises to revolutionize precision oncology by offering personalized approaches informed by comprehensive mutational patterns of tumors. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 10.1002/path.6300 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/path.6300 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_path_6300 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Beyond driver mutations: exploring the landscape of mutational signatures in adenocarcinomas of the bladder† Tibor Szarvas Henning Reis The Journal of Pathology Beyond driver mutations: exploring the landscape of mutational signatures in adenocarcinomas of the bladder† Tibor Szarvas Henning Reis The Journal of Pathology AbstractThe emergence of mutational signatures in cancer research represents a paradigm shift, offering profound insights into tumor biology, therapeutic strategies, and risk assessment. A recent article published in The Journal of Pathology delves into the significance of mutational signatures, assessing their role as molecular fingerprints that illuminate the etiology of individual cancer cases. By deciphering the diverse patterns of DNA alterations, in the context of urachal and nonurachal bladder adenocarcinomas, researchers can unravel intrinsic and environmental risk factors shaping cancer development. The study highlighted a predominance of environmental risk factors in Chinese populations affected by bladder adenocarcinomas. In this context, in this commentary, we highlight some of the potential applications of molecular signatures in differential diagnosis and therapy prediction. As the field continues to evolve, a deeper understanding of mutational signatures promises to revolutionize precision oncology by offering personalized approaches informed by comprehensive mutational patterns of tumors. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 10.1002/path.6300 http://creativecommons.org/licenses/by/4.0/ |
| title | Beyond driver mutations: exploring the landscape of mutational signatures in adenocarcinomas of the bladder† |
| topic | The Journal of Pathology |
| url | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6300 |