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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2024
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| Online Access: | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6345 |
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| author | Aki Sato Nozomi Yusa Hiroyuki Takamori Eigo Shimizu Kazuaki Yokoyama Satoshi Ichikawa Hisayuki Yokoyama Yuki Kasahara Kodai Enda Fumiyoshi Fujishima Ryo Ichinohasama Yasunori Ota Seiya Imoto Yasuhito Nannya |
| author_facet | Aki Sato Nozomi Yusa Hiroyuki Takamori Eigo Shimizu Kazuaki Yokoyama Satoshi Ichikawa Hisayuki Yokoyama Yuki Kasahara Kodai Enda Fumiyoshi Fujishima Ryo Ichinohasama Yasunori Ota Seiya Imoto Yasuhito Nannya Aki Sato Nozomi Yusa Hiroyuki Takamori Eigo Shimizu Kazuaki Yokoyama Satoshi Ichikawa Hisayuki Yokoyama Yuki Kasahara Kodai Enda Fumiyoshi Fujishima Ryo Ichinohasama Yasunori Ota Seiya Imoto Yasuhito Nannya |
| collection | Wiley Open Access |
| contents | Common progenitor origin for Rosai–Dorfman disease and clear cell sarcoma Aki Sato Nozomi Yusa Hiroyuki Takamori Eigo Shimizu Kazuaki Yokoyama Satoshi Ichikawa Hisayuki Yokoyama Yuki Kasahara Kodai Enda Fumiyoshi Fujishima Ryo Ichinohasama Yasunori Ota Seiya Imoto Yasuhito Nannya The Journal of Pathology AbstractHistiocytic neoplasms (HNs) in adults have been reported to be associated with a high prevalence of coexisting haematological and solid malignancies. While a proportion of coexisting HNs and haematological malignancies share identical genetic alterations, the genetic association between HNs and solid malignancies has scarcely been reported. We report a case of Rosai–Dorfman disease (RDD) complicated by coexisting clear cell sarcoma (CCS). RDD is a rare HN. CCS is an ultrarare soft tissue sarcoma with a poor prognosis. Mutation analysis with whole‐exome sequencing revealed six shared somatic alterations including NRAS p.G12S and TP53 c.559+1G>A in both the RDD and CCS tissue. This is the first evidence of a clonal relationship between RDD and solid malignancies using mutational analysis. We hypothesise that neural crest cells, which originate in CCS, are likely the common cells of origin for RDD and CCS. This case helps to unravel the underlying clinicopathological mechanisms of increased association of solid malignancies in HNs. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 10.1002/path.6345 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/path.6345 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_path_6345 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Common progenitor origin for Rosai–Dorfman disease and clear cell sarcoma Aki Sato Nozomi Yusa Hiroyuki Takamori Eigo Shimizu Kazuaki Yokoyama Satoshi Ichikawa Hisayuki Yokoyama Yuki Kasahara Kodai Enda Fumiyoshi Fujishima Ryo Ichinohasama Yasunori Ota Seiya Imoto Yasuhito Nannya The Journal of Pathology Common progenitor origin for Rosai–Dorfman disease and clear cell sarcoma Aki Sato Nozomi Yusa Hiroyuki Takamori Eigo Shimizu Kazuaki Yokoyama Satoshi Ichikawa Hisayuki Yokoyama Yuki Kasahara Kodai Enda Fumiyoshi Fujishima Ryo Ichinohasama Yasunori Ota Seiya Imoto Yasuhito Nannya The Journal of Pathology AbstractHistiocytic neoplasms (HNs) in adults have been reported to be associated with a high prevalence of coexisting haematological and solid malignancies. While a proportion of coexisting HNs and haematological malignancies share identical genetic alterations, the genetic association between HNs and solid malignancies has scarcely been reported. We report a case of Rosai–Dorfman disease (RDD) complicated by coexisting clear cell sarcoma (CCS). RDD is a rare HN. CCS is an ultrarare soft tissue sarcoma with a poor prognosis. Mutation analysis with whole‐exome sequencing revealed six shared somatic alterations including NRAS p.G12S and TP53 c.559+1G>A in both the RDD and CCS tissue. This is the first evidence of a clonal relationship between RDD and solid malignancies using mutational analysis. We hypothesise that neural crest cells, which originate in CCS, are likely the common cells of origin for RDD and CCS. This case helps to unravel the underlying clinicopathological mechanisms of increased association of solid malignancies in HNs. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 10.1002/path.6345 http://creativecommons.org/licenses/by/4.0/ |
| title | Common progenitor origin for Rosai–Dorfman disease and clear cell sarcoma |
| topic | The Journal of Pathology |
| url | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6345 |