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| Main Authors: | , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2024
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| Online Access: | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6375 |
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| _version_ | 1867002437401837568 |
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| author | Astrid Van den Branden Britt Opdebeeck Saar Adriaensen Pieter Evenepoel Tom Vanden Berghe Anja Verhulst |
| author_facet | Astrid Van den Branden Britt Opdebeeck Saar Adriaensen Pieter Evenepoel Tom Vanden Berghe Anja Verhulst Astrid Van den Branden Britt Opdebeeck Saar Adriaensen Pieter Evenepoel Tom Vanden Berghe Anja Verhulst |
| collection | Wiley Open Access |
| contents | Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats Astrid Van den Branden Britt Opdebeeck Saar Adriaensen Pieter Evenepoel Tom Vanden Berghe Anja Verhulst The Journal of Pathology Abstract Arterial media calcification is a severe cardiovascular complication commonly manifesting in patients with chronic kidney disease (CKD). Patients with CKD frequently undergo intravenous iron therapy to address iron deficiency. Iron is suggested to be sequestered in vascular cells, potentially leading to oxidative (lipid) stress and cell death, which are recognized as key contributors to arterial calcification. The objective of this study was to investigate the effect of intravenous iron administration on CKD‐induced arterial media calcification. Therefore, adenine‐induced CKD rats were treated intravenously with iron and checked for arterial iron deposition and calcification, as well as for ferritin and lipid peroxidation markers. Additionally, arterial sections from patients with CKD who were dialysis dependent were analyzed for these parameters. This study showed that intravenous iron administration in CKD rats led to arterial iron deposition and a lipid peroxidation signature. CKD‐induced arterial calcification was increased upon iron treatment and correlated with arterial iron accumulation and lipid peroxidation markers. Patients with CKD who were dialysis dependent showed arterial iron accumulation and elevated lipid peroxidation, but a direct correlation with arterial calcification was lacking. Taken together, iron treatment is suggested as a potential contributor to the calcification process, instead of being a predominant factor, thereby emphasizing the complexity of arterial calcification as a multifactorial disease. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 10.1002/path.6375 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1002/path.6375 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_path_6375 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats Astrid Van den Branden Britt Opdebeeck Saar Adriaensen Pieter Evenepoel Tom Vanden Berghe Anja Verhulst The Journal of Pathology Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats Astrid Van den Branden Britt Opdebeeck Saar Adriaensen Pieter Evenepoel Tom Vanden Berghe Anja Verhulst The Journal of Pathology Abstract Arterial media calcification is a severe cardiovascular complication commonly manifesting in patients with chronic kidney disease (CKD). Patients with CKD frequently undergo intravenous iron therapy to address iron deficiency. Iron is suggested to be sequestered in vascular cells, potentially leading to oxidative (lipid) stress and cell death, which are recognized as key contributors to arterial calcification. The objective of this study was to investigate the effect of intravenous iron administration on CKD‐induced arterial media calcification. Therefore, adenine‐induced CKD rats were treated intravenously with iron and checked for arterial iron deposition and calcification, as well as for ferritin and lipid peroxidation markers. Additionally, arterial sections from patients with CKD who were dialysis dependent were analyzed for these parameters. This study showed that intravenous iron administration in CKD rats led to arterial iron deposition and a lipid peroxidation signature. CKD‐induced arterial calcification was increased upon iron treatment and correlated with arterial iron accumulation and lipid peroxidation markers. Patients with CKD who were dialysis dependent showed arterial iron accumulation and elevated lipid peroxidation, but a direct correlation with arterial calcification was lacking. Taken together, iron treatment is suggested as a potential contributor to the calcification process, instead of being a predominant factor, thereby emphasizing the complexity of arterial calcification as a multifactorial disease. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 10.1002/path.6375 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats |
| topic | The Journal of Pathology |
| url | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6375 |