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| Main Authors: | , , , , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2025
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| Subjects: | |
| Online Access: | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6456 |
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Table of Contents:
- Revisionist history uncovers a simplified molecular‐based classification of differentiated thyroid cancer Sylvia L Asa Zubair Baloch Chan Kwon Jung Nicole A Cipriani Armando Gamboa‐Domínguez C Christofer Juhlin Nicole D Riddle Ivan J Stojanov Ozgur Mete The Journal of Pathology AbstractThe diagnostic classification of differentiated thyroid cancer has been a longstanding topic of debate among pathologists, largely due to high interobserver variability. This complexity has increased with the expansion of tumor types and subtypes. However, molecular studies have revealed a simpler and less controversial approach, categorizing these lesions into RAS‐like and BRAF p.V600E‐like neoplasms. In this review, the authors propose a classification that is based on, but does not require, the confirmation of molecular alterations. This approach aligns with and helps inform the pattern‐based assessment of tumor growth and cytologic atypia that is already widely used in clinical practice for preoperative patient stratification and tumor diagnosis, and promises a simpler conceptual understanding. © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 10.1002/path.6456 http://creativecommons.org/licenses/by-nc-nd/4.0/