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| Natura: | Artículo Open Access |
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Wiley
2025
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| Accesso online: | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6474 |
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| _version_ | 1867011550329438208 |
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| author | Sangkyou Lee Sung Yun Jung Pawel Kuś Jolanta Bondaruk June Goo Lee Roman Jaksik Nagireddy Putluri Khanh N Dinh David Cogdell Huiqin Chen Yishan Wang Jiansong Chen Neema Navai Colin Dinney Cathy Mendelsohn David McConkey Richard R Behringer Charles C Guo Peng Wei Marek Kimmel Bogdan Czerniak |
| author_facet | Sangkyou Lee Sung Yun Jung Pawel Kuś Jolanta Bondaruk June Goo Lee Roman Jaksik Nagireddy Putluri Khanh N Dinh David Cogdell Huiqin Chen Yishan Wang Jiansong Chen Neema Navai Colin Dinney Cathy Mendelsohn David McConkey Richard R Behringer Charles C Guo Peng Wei Marek Kimmel Bogdan Czerniak Sangkyou Lee Sung Yun Jung Pawel Kuś Jolanta Bondaruk June Goo Lee Roman Jaksik Nagireddy Putluri Khanh N Dinh David Cogdell Huiqin Chen Yishan Wang Jiansong Chen Neema Navai Colin Dinney Cathy Mendelsohn David McConkey Richard R Behringer Charles C Guo Peng Wei Marek Kimmel Bogdan Czerniak |
| collection | Wiley Open Access |
| contents | Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer Sangkyou Lee Sung Yun Jung Pawel Kuś Jolanta Bondaruk June Goo Lee Roman Jaksik Nagireddy Putluri Khanh N Dinh David Cogdell Huiqin Chen Yishan Wang Jiansong Chen Neema Navai Colin Dinney Cathy Mendelsohn David McConkey Richard R Behringer Charles C Guo Peng Wei Marek Kimmel Bogdan Czerniak The Journal of Pathology AbstractMultiplatform mutational and gene expression profiling complemented with proteomic and metabolomic spatial mapping were used on the whole‐organ scale to identify the molecular profile of bladder cancer evolution from field effects. Analysis of the mutational landscape identified three types of mutations, referred to as α, β, and γ. Time modeling of the mutations revealed that carcinogenesis may span 30 years and can be divided into dormant and progressive phases. The α mutations developed in the dormant phase. The progressive phase lasted 5 years and was signified by expanding β mutations, but it was driven to invasive cancer by γ mutations. The mutational landscape emerged on a background of disorganized urothelial differentiation, activated epithelial‐mesenchymal transition, and enhanced immune infiltration with T‐cell exhaustion. Complex dysregulation of mitochondrial energy metabolism with downregulation of oxidative phosphorylation emerged as the leading mechanism driving the progression of mucosal field effects to invasive cancer. © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 10.1002/path.6474 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/path.6474 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_path_6474 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer Sangkyou Lee Sung Yun Jung Pawel Kuś Jolanta Bondaruk June Goo Lee Roman Jaksik Nagireddy Putluri Khanh N Dinh David Cogdell Huiqin Chen Yishan Wang Jiansong Chen Neema Navai Colin Dinney Cathy Mendelsohn David McConkey Richard R Behringer Charles C Guo Peng Wei Marek Kimmel Bogdan Czerniak The Journal of Pathology Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer Sangkyou Lee Sung Yun Jung Pawel Kuś Jolanta Bondaruk June Goo Lee Roman Jaksik Nagireddy Putluri Khanh N Dinh David Cogdell Huiqin Chen Yishan Wang Jiansong Chen Neema Navai Colin Dinney Cathy Mendelsohn David McConkey Richard R Behringer Charles C Guo Peng Wei Marek Kimmel Bogdan Czerniak The Journal of Pathology AbstractMultiplatform mutational and gene expression profiling complemented with proteomic and metabolomic spatial mapping were used on the whole‐organ scale to identify the molecular profile of bladder cancer evolution from field effects. Analysis of the mutational landscape identified three types of mutations, referred to as α, β, and γ. Time modeling of the mutations revealed that carcinogenesis may span 30 years and can be divided into dormant and progressive phases. The α mutations developed in the dormant phase. The progressive phase lasted 5 years and was signified by expanding β mutations, but it was driven to invasive cancer by γ mutations. The mutational landscape emerged on a background of disorganized urothelial differentiation, activated epithelial‐mesenchymal transition, and enhanced immune infiltration with T‐cell exhaustion. Complex dysregulation of mitochondrial energy metabolism with downregulation of oxidative phosphorylation emerged as the leading mechanism driving the progression of mucosal field effects to invasive cancer. © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 10.1002/path.6474 http://creativecommons.org/licenses/by/4.0/ |
| title | Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer |
| topic | The Journal of Pathology |
| url | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6474 |