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| Formato: | Artículo Open Access |
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Wiley
2026
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| Acceso en línea: | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.70049 |
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| _version_ | 1867014576982196224 |
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| author | Andrew C Pearson Odei Barreñada Miguel Angel Brieño‐Enríquez |
| author_facet | Andrew C Pearson Odei Barreñada Miguel Angel Brieño‐Enríquez Andrew C Pearson Odei Barreñada Miguel Angel Brieño‐Enríquez |
| collection | Wiley Open Access |
| contents | Could the naked mole‐rat become the new standard for studying human gut health and probiotics? † Andrew C Pearson Odei Barreñada Miguel Angel Brieño‐Enríquez The Journal of Pathology Abstract The naked mole‐rat (NMR; Heterocephalus glaber ) is a subterranean rodent native to the arid regions of the Horn of Africa. The NMR is the longest‐lived rodent and is known for its distinctive physiological and social traits. This species has become a notable model organism for studying aging, cancer biology, behavioral ecology, and reproduction. Recently, NMRs have gained attention because their gastrointestinal tract features an exceptionally strong intestinal barrier, a large number of goblet cells, a thicker mucin layer, and reduced gut permeability. The NMR gut microbiome, similar to that observed in human centenarians, is highly diverse and characterized by a high microbial load. In fact, Hart et al (2026) demonstrated that spontaneous infection with Citrobacter braakii in the NMR causes clinical symptoms and histopathological changes that are very similar to those observed in human colitis. If left untreated, the disease can progress and become fatal. However, probiotic treatment can reverse the clinical and histopathological phenotypes. These findings indicate that, in addition to serving as a powerful model for aging, cancer, and reproduction, the NMR may also serve as a powerful tool for studying human diseases such as gut dysbiosis, gut barrier dysfunction, and colitis. © 2026 The Pathological Society of Great Britain and Ireland. 10.1002/path.70049 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/path.70049 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_path_70049 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Could the naked mole‐rat become the new standard for studying human gut health and probiotics? † Andrew C Pearson Odei Barreñada Miguel Angel Brieño‐Enríquez The Journal of Pathology Could the naked mole‐rat become the new standard for studying human gut health and probiotics? † Andrew C Pearson Odei Barreñada Miguel Angel Brieño‐Enríquez The Journal of Pathology Abstract The naked mole‐rat (NMR; Heterocephalus glaber ) is a subterranean rodent native to the arid regions of the Horn of Africa. The NMR is the longest‐lived rodent and is known for its distinctive physiological and social traits. This species has become a notable model organism for studying aging, cancer biology, behavioral ecology, and reproduction. Recently, NMRs have gained attention because their gastrointestinal tract features an exceptionally strong intestinal barrier, a large number of goblet cells, a thicker mucin layer, and reduced gut permeability. The NMR gut microbiome, similar to that observed in human centenarians, is highly diverse and characterized by a high microbial load. In fact, Hart et al (2026) demonstrated that spontaneous infection with Citrobacter braakii in the NMR causes clinical symptoms and histopathological changes that are very similar to those observed in human colitis. If left untreated, the disease can progress and become fatal. However, probiotic treatment can reverse the clinical and histopathological phenotypes. These findings indicate that, in addition to serving as a powerful model for aging, cancer, and reproduction, the NMR may also serve as a powerful tool for studying human diseases such as gut dysbiosis, gut barrier dysfunction, and colitis. © 2026 The Pathological Society of Great Britain and Ireland. 10.1002/path.70049 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Could the naked mole‐rat become the new standard for studying human gut health and probiotics? † |
| topic | The Journal of Pathology |
| url | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.70049 |