Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2024
|
| Sujets: | |
| Accès en ligne: | https://onlinelibrary.wiley.com/doi/10.1002/pbc.31021 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1867019015083261952 |
|---|---|
| author | Pooja Soni Bhavna Dhingra Samendra Karkhur Narendra K. Chaudhary Abhijit P. Pakhare |
| author_facet | Pooja Soni Bhavna Dhingra Samendra Karkhur Narendra K. Chaudhary Abhijit P. Pakhare Pooja Soni Bhavna Dhingra Samendra Karkhur Narendra K. Chaudhary Abhijit P. Pakhare |
| collection | Wiley Open Access |
| contents | Early diagnosis of sickle cell retinopathy by using ocular coherence tomography in pediatric population (7–18 years) in central India Pooja Soni Bhavna Dhingra Samendra Karkhur Narendra K. Chaudhary Abhijit P. Pakhare Pediatric Blood & Cancer Abstract Background Sickle cell disease (SCD) is the commonest inherited blood disorder leading to complications occurring due to vaso‐occlusion including sight‐threatening retinopathy. Retinopathy can be managed if diagnosed early and vision loss can be prevented. Since, very less data are available from India, hence, this study was conducted in children (7–18 years) with SCD to diagnose retinopathy by using ocular coherence tomography (OCT) in subclinical stages. Methods This cross sectional single‐center study was performed in 7–18 years age group children with SCD without any visual symptoms. Enrolled participants underwent complete ophthalmological examination including macula and optic disc thickness measurements using Cirrus HD‐OCT and results were analyzed. Results Among 55 participants, none had visual impairment. Significant fundoscopy finding (nonproliferative sickle cell retinopathy/NPSR) was found in three patients (5.4%), thinning of central macula in four patients (7.27%), inner macula thinning in eight patients (14.5%), outer macula thinning in one patient (1.81%), retinal nerve fiber layer thinning in five patients (9%), ganglion cell layer to inner plexiform layer thinning in eight patients (14.54%). Overall NPSR was found in 5.4% patients detected with fundoscopy, whereas retinal layer thinning was found in 14 patients (25.4%) using OCT. Conclusion Despite of the significant prevalence of SCR, it is still underdiagnosed complication, leading to thinning of the retina from early ages; thus, its early diagnosis by regular screening using newer diagnostic methods can prevent progression to sight‐threatening complications and provide better quality of life for these patients. 10.1002/pbc.31021 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/pbc.31021 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_pbc_31021 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Early diagnosis of sickle cell retinopathy by using ocular coherence tomography in pediatric population (7–18 years) in central India Pooja Soni Bhavna Dhingra Samendra Karkhur Narendra K. Chaudhary Abhijit P. Pakhare Pediatric Blood & Cancer Early diagnosis of sickle cell retinopathy by using ocular coherence tomography in pediatric population (7–18 years) in central India Pooja Soni Bhavna Dhingra Samendra Karkhur Narendra K. Chaudhary Abhijit P. Pakhare Pediatric Blood & Cancer Abstract Background Sickle cell disease (SCD) is the commonest inherited blood disorder leading to complications occurring due to vaso‐occlusion including sight‐threatening retinopathy. Retinopathy can be managed if diagnosed early and vision loss can be prevented. Since, very less data are available from India, hence, this study was conducted in children (7–18 years) with SCD to diagnose retinopathy by using ocular coherence tomography (OCT) in subclinical stages. Methods This cross sectional single‐center study was performed in 7–18 years age group children with SCD without any visual symptoms. Enrolled participants underwent complete ophthalmological examination including macula and optic disc thickness measurements using Cirrus HD‐OCT and results were analyzed. Results Among 55 participants, none had visual impairment. Significant fundoscopy finding (nonproliferative sickle cell retinopathy/NPSR) was found in three patients (5.4%), thinning of central macula in four patients (7.27%), inner macula thinning in eight patients (14.5%), outer macula thinning in one patient (1.81%), retinal nerve fiber layer thinning in five patients (9%), ganglion cell layer to inner plexiform layer thinning in eight patients (14.54%). Overall NPSR was found in 5.4% patients detected with fundoscopy, whereas retinal layer thinning was found in 14 patients (25.4%) using OCT. Conclusion Despite of the significant prevalence of SCR, it is still underdiagnosed complication, leading to thinning of the retina from early ages; thus, its early diagnosis by regular screening using newer diagnostic methods can prevent progression to sight‐threatening complications and provide better quality of life for these patients. 10.1002/pbc.31021 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Early diagnosis of sickle cell retinopathy by using ocular coherence tomography in pediatric population (7–18 years) in central India |
| topic | Pediatric Blood & Cancer |
| url | https://onlinelibrary.wiley.com/doi/10.1002/pbc.31021 |