Characteristics of Transfusion and Association With Oncologic Outcomes in Hepatoblastoma Resection
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2025
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| author | Stephanie F. Polites Jennifer H. Aldrink Timothy B. Lautz Robert A. Vierkant Mecklin V. Ragan Audra Reiter Stephanie Y. Chen Eugene S. Kim Hannah N. Rinehardt Marcus M. Malek Andrew M. Fleming Andrew J. Murphy Jonathan P. Roach Sridharan Radhakrishnan Zachary J. Kastenberg Nelson Piche Yasmin Osman Harold N. Lovvorn III Elisabeth T. Tracy Juan Favela Hau D. Le John Marquart Brian Craig Dave R. Lal Natashia Seemann Robin Petroze Barrie S. Rich Richard D. Glick Leigh Selesner Ashley Yoo Elizabeth Fialkowski Erin G. Brown Chloe Boehmer Roshni Dasgupta Max R. Langham |
| author_facet | Stephanie F. Polites Jennifer H. Aldrink Timothy B. Lautz Robert A. Vierkant Mecklin V. Ragan Audra Reiter Stephanie Y. Chen Eugene S. Kim Hannah N. Rinehardt Marcus M. Malek Andrew M. Fleming Andrew J. Murphy Jonathan P. Roach Sridharan Radhakrishnan Zachary J. Kastenberg Nelson Piche Yasmin Osman Harold N. Lovvorn III Elisabeth T. Tracy Juan Favela Hau D. Le John Marquart Brian Craig Dave R. Lal Natashia Seemann Robin Petroze Barrie S. Rich Richard D. Glick Leigh Selesner Ashley Yoo Elizabeth Fialkowski Erin G. Brown Chloe Boehmer Roshni Dasgupta Max R. Langham Stephanie F. Polites Jennifer H. Aldrink Timothy B. Lautz Robert A. Vierkant Mecklin V. Ragan Audra Reiter Stephanie Y. Chen Eugene S. Kim Hannah N. Rinehardt Marcus M. Malek Andrew M. Fleming Andrew J. Murphy Jonathan P. Roach Sridharan Radhakrishnan Zachary J. Kastenberg Nelson Piche Yasmin Osman Harold N. Lovvorn III Elisabeth T. Tracy Juan Favela Hau D. Le John Marquart Brian Craig Dave R. Lal Natashia Seemann Robin Petroze Barrie S. Rich Richard D. Glick Leigh Selesner Ashley Yoo Elizabeth Fialkowski Erin G. Brown Chloe Boehmer Roshni Dasgupta Max R. Langham |
| collection | Wiley Open Access |
| contents | Characteristics of Transfusion and Association With Oncologic Outcomes in Hepatoblastoma Resection Stephanie F. Polites Jennifer H. Aldrink Timothy B. Lautz Robert A. Vierkant Mecklin V. Ragan Audra Reiter Stephanie Y. Chen Eugene S. Kim Hannah N. Rinehardt Marcus M. Malek Andrew M. Fleming Andrew J. Murphy Jonathan P. Roach Sridharan Radhakrishnan Zachary J. Kastenberg Nelson Piche Yasmin Osman Harold N. Lovvorn III Elisabeth T. Tracy Juan Favela Hau D. Le John Marquart Brian Craig Dave R. Lal Natashia Seemann Robin Petroze Barrie S. Rich Richard D. Glick Leigh Selesner Ashley Yoo Elizabeth Fialkowski Erin G. Brown Chloe Boehmer Roshni Dasgupta Max R. Langham Pediatric Blood & Cancer ABSTRACT Introduction Children with hepatoblastoma (HB) and other solid tumors frequently undergo intraoperative blood transfusion (IBT) with unknown impact on oncologic outcomes and scant data to guide transfusion in this population. This study tested the hypothesis that IBT is associated with poorer survival in children with HB. Methods A multicenter retrospective observational study of patients aged <18 years with HB who underwent primary tumor resection, including liver transplantation, from 2010 to 2019 was performed at 19 institutions. The association of IBT with risk of recurrence and death were determined using propensity score reweighted (PSR) Cox proportional hazards regression analyses. Results There were 338 patients identified who met inclusion criteria and had sufficient data for inclusion. Of those, 257 (76%) received IBT, including 253 (98%) who received packed red blood cells (pRBC), 84 (33%) who received plasma, and 28 (11%) who received platelets. IBT was associated with higher pretreatment extent of disease ( p < 0.001), presence of annotation factors (+VPEFR: 50%, n = 129 vs. 37%, n = 30, p = 0.035), and complex resections (extended, meso‐, or total hepatectomy: 54%, n = 139 vs. 27%, n = 22, p < 0.001); these differences were mitigated after applying propensity score weighting. Patients who received IBT had greater postoperative hemoglobin (g/dL) (median 10 (I8–11) vs. 9 (8–10), p = 0.013) and required more postoperative plasma and platelet transfusions ( p < 0.05). Median follow‐up was 4.4 (2.0–8.3) years. Compared with non‐IBT patients, those with IBT had higher incidence of death (PSR HR 2.35, 95% CI 1.10–5.02). Recurrence did not significantly differ across groups (PSR HR = 0.82, 95% CI 0.45–1.48). Conclusion IBT was associated with greater hazard of death. Postoperative hemoglobin levels suggested that unnecessary transfusions occurred and a pRBC‐focused approach to IBT led to coagulopathy. Development of optimal transfusion strategies for HB are needed to minimize unnecessary transfusions. 10.1002/pbc.32029 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/pbc.32029 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_pbc_32029 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Characteristics of Transfusion and Association With Oncologic Outcomes in Hepatoblastoma Resection Stephanie F. Polites Jennifer H. Aldrink Timothy B. Lautz Robert A. Vierkant Mecklin V. Ragan Audra Reiter Stephanie Y. Chen Eugene S. Kim Hannah N. Rinehardt Marcus M. Malek Andrew M. Fleming Andrew J. Murphy Jonathan P. Roach Sridharan Radhakrishnan Zachary J. Kastenberg Nelson Piche Yasmin Osman Harold N. Lovvorn III Elisabeth T. Tracy Juan Favela Hau D. Le John Marquart Brian Craig Dave R. Lal Natashia Seemann Robin Petroze Barrie S. Rich Richard D. Glick Leigh Selesner Ashley Yoo Elizabeth Fialkowski Erin G. Brown Chloe Boehmer Roshni Dasgupta Max R. Langham Pediatric Blood & Cancer Characteristics of Transfusion and Association With Oncologic Outcomes in Hepatoblastoma Resection Stephanie F. Polites Jennifer H. Aldrink Timothy B. Lautz Robert A. Vierkant Mecklin V. Ragan Audra Reiter Stephanie Y. Chen Eugene S. Kim Hannah N. Rinehardt Marcus M. Malek Andrew M. Fleming Andrew J. Murphy Jonathan P. Roach Sridharan Radhakrishnan Zachary J. Kastenberg Nelson Piche Yasmin Osman Harold N. Lovvorn III Elisabeth T. Tracy Juan Favela Hau D. Le John Marquart Brian Craig Dave R. Lal Natashia Seemann Robin Petroze Barrie S. Rich Richard D. Glick Leigh Selesner Ashley Yoo Elizabeth Fialkowski Erin G. Brown Chloe Boehmer Roshni Dasgupta Max R. Langham Pediatric Blood & Cancer ABSTRACT Introduction Children with hepatoblastoma (HB) and other solid tumors frequently undergo intraoperative blood transfusion (IBT) with unknown impact on oncologic outcomes and scant data to guide transfusion in this population. This study tested the hypothesis that IBT is associated with poorer survival in children with HB. Methods A multicenter retrospective observational study of patients aged <18 years with HB who underwent primary tumor resection, including liver transplantation, from 2010 to 2019 was performed at 19 institutions. The association of IBT with risk of recurrence and death were determined using propensity score reweighted (PSR) Cox proportional hazards regression analyses. Results There were 338 patients identified who met inclusion criteria and had sufficient data for inclusion. Of those, 257 (76%) received IBT, including 253 (98%) who received packed red blood cells (pRBC), 84 (33%) who received plasma, and 28 (11%) who received platelets. IBT was associated with higher pretreatment extent of disease ( p < 0.001), presence of annotation factors (+VPEFR: 50%, n = 129 vs. 37%, n = 30, p = 0.035), and complex resections (extended, meso‐, or total hepatectomy: 54%, n = 139 vs. 27%, n = 22, p < 0.001); these differences were mitigated after applying propensity score weighting. Patients who received IBT had greater postoperative hemoglobin (g/dL) (median 10 (I8–11) vs. 9 (8–10), p = 0.013) and required more postoperative plasma and platelet transfusions ( p < 0.05). Median follow‐up was 4.4 (2.0–8.3) years. Compared with non‐IBT patients, those with IBT had higher incidence of death (PSR HR 2.35, 95% CI 1.10–5.02). Recurrence did not significantly differ across groups (PSR HR = 0.82, 95% CI 0.45–1.48). Conclusion IBT was associated with greater hazard of death. Postoperative hemoglobin levels suggested that unnecessary transfusions occurred and a pRBC‐focused approach to IBT led to coagulopathy. Development of optimal transfusion strategies for HB are needed to minimize unnecessary transfusions. 10.1002/pbc.32029 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Characteristics of Transfusion and Association With Oncologic Outcomes in Hepatoblastoma Resection |
| topic | Pediatric Blood & Cancer |
| url | https://onlinelibrary.wiley.com/doi/10.1002/pbc.32029 |