LINE‐1 Retroelement Activation and Neuroinflammation in Persons With Fanconi Anemia
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| Formato: | Artículo Open Access |
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Wiley
2025
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| _version_ | 1867013169291984896 |
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| author | Allison L. Bartlett Kristie N. Ramos Jamen R. Bartlett Kenneth S. Ramos Nathan Luebbering Kasiani C. Myers Parinda A. Mehta Stella M. Davies |
| author_facet | Allison L. Bartlett Kristie N. Ramos Jamen R. Bartlett Kenneth S. Ramos Nathan Luebbering Kasiani C. Myers Parinda A. Mehta Stella M. Davies Allison L. Bartlett Kristie N. Ramos Jamen R. Bartlett Kenneth S. Ramos Nathan Luebbering Kasiani C. Myers Parinda A. Mehta Stella M. Davies |
| collection | Wiley Open Access |
| contents | LINE‐1 Retroelement Activation and Neuroinflammation in Persons With Fanconi Anemia Allison L. Bartlett Kristie N. Ramos Jamen R. Bartlett Kenneth S. Ramos Nathan Luebbering Kasiani C. Myers Parinda A. Mehta Stella M. Davies Pediatric Blood & Cancer ABSTRACT We describe the first immunohistochemical analysis performed on brain lesion biopsies from two young individuals with Fanconi anemia neuroinflammatory syndrome (FANS). We identified aberrant activation of the LINE‐1 retrotransposon as a novel mechanism of neuroinflammation in individuals with hematological disorders. LINE‐1 ORF‐1 protein is upregulated in biopsies of inflammatory lesions compared to brain tissue from persons with FA without FANS, and shows activation of an innate immune response with increased STING and IFI6 expression. Awareness among hematologists is vital, as this condition can mimic an aggressive brain tumor both clinically and radiographically, and the proposed mechanism has meaningful therapeutic implications. 10.1002/pbc.32081 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1002/pbc.32081 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_pbc_32081 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | LINE‐1 Retroelement Activation and Neuroinflammation in Persons With Fanconi Anemia Allison L. Bartlett Kristie N. Ramos Jamen R. Bartlett Kenneth S. Ramos Nathan Luebbering Kasiani C. Myers Parinda A. Mehta Stella M. Davies Pediatric Blood & Cancer LINE‐1 Retroelement Activation and Neuroinflammation in Persons With Fanconi Anemia Allison L. Bartlett Kristie N. Ramos Jamen R. Bartlett Kenneth S. Ramos Nathan Luebbering Kasiani C. Myers Parinda A. Mehta Stella M. Davies Pediatric Blood & Cancer ABSTRACT We describe the first immunohistochemical analysis performed on brain lesion biopsies from two young individuals with Fanconi anemia neuroinflammatory syndrome (FANS). We identified aberrant activation of the LINE‐1 retrotransposon as a novel mechanism of neuroinflammation in individuals with hematological disorders. LINE‐1 ORF‐1 protein is upregulated in biopsies of inflammatory lesions compared to brain tissue from persons with FA without FANS, and shows activation of an innate immune response with increased STING and IFI6 expression. Awareness among hematologists is vital, as this condition can mimic an aggressive brain tumor both clinically and radiographically, and the proposed mechanism has meaningful therapeutic implications. 10.1002/pbc.32081 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | LINE‐1 Retroelement Activation and Neuroinflammation in Persons With Fanconi Anemia |
| topic | Pediatric Blood & Cancer |
| url | https://onlinelibrary.wiley.com/doi/10.1002/pbc.32081 |