Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement: A meta‐analysis
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2026
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| author | Muhammad Huzaifa Ahmed Khan Muneeb Khawar Asad Ullah Farooq Azooba Khalid Syed Muhammad Ahsan M. Hamza Naseer Awan Muhammad Soban Nisar Asim Elahi Muhammad Aqib Faizan Iqra Shahid Abdullah Munir Ahmed Faseeh Haider Rejina Chhetri |
| author_facet | Muhammad Huzaifa Ahmed Khan Muneeb Khawar Asad Ullah Farooq Azooba Khalid Syed Muhammad Ahsan M. Hamza Naseer Awan Muhammad Soban Nisar Asim Elahi Muhammad Aqib Faizan Iqra Shahid Abdullah Munir Ahmed Faseeh Haider Rejina Chhetri Muhammad Huzaifa Ahmed Khan Muneeb Khawar Asad Ullah Farooq Azooba Khalid Syed Muhammad Ahsan M. Hamza Naseer Awan Muhammad Soban Nisar Asim Elahi Muhammad Aqib Faizan Iqra Shahid Abdullah Munir Ahmed Faseeh Haider Rejina Chhetri |
| collection | Wiley Open Access |
| contents | Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement: A meta‐analysis Muhammad Huzaifa Ahmed Khan Muneeb Khawar Asad Ullah Farooq Azooba Khalid Syed Muhammad Ahsan M. Hamza Naseer Awan Muhammad Soban Nisar Asim Elahi Muhammad Aqib Faizan Iqra Shahid Abdullah Munir Ahmed Faseeh Haider Rejina Chhetri Precision Medical Sciences Abstract Bicuspid aortic valve (BAV) is a common congenital anomaly leading to early aortic stenosis. Although transcatheter aortic valve replacement (TAVR) offers a less invasive treatment for BAV stenosis, sex‐specific outcome data are scarce. This study evaluates clinical outcomes after TAVR by sex in BAV patients. A systematic literature search was performed across PubMed, ClinicalTrials.gov , and Cochrane CENTRAL to identify relevant English‐language randomized controlled trials and observational studies. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using fixed‐ or random‐effects models based on heterogeneity. Statistical significance was set at p < .05, and heterogeneity was assessed using the I 2 statistic. Analyses were performed with Review Manager Version 5.3. Four observational studies comprising 7585 patients met inclusion criteria. Males had a higher incidence of acute kidney injury (AKI) (RR = 1.33; 95% CI: 1.13–1.57; p = .0008) and acute myocardial infarction (MI) (RR = 2.18; 95% CI: 1.54–3.07; p = .00001), but a lower risk of in‐hospital mortality (RR = 0.71; 95% CI: 0.51–0.99; p = .04), stroke (RR = 0.70; 95% CI: 0.50–0.95; p = .02), and bleeding (RR = 0.79; 95% CI: 0.63–0.98; p = .03) compared to females. No statistically significant differences were observed in one‐year mortality (RR = 1.08; 95% CI: 0.58–2.03; p = .81), 30‐day mortality (RR = 1.18; 95% CI: 0.51–2.75; p = .69), or arrhythmia (RR = 0.83; 95% CI: 0.52–1.33; p = .45). Males had increased risks of AKI and MI, while females experienced higher in‐hospital mortality, stroke, and bleeding. These findings, derived from a limited number of retrospective observational studies, are hypothesis‐generating and highlight the need for sex‐specific risk stratification and further prospective research to confirm these patterns and guide clinical practice. 10.1002/prm2.70021 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/prm2.70021 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_prm2_70021 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement: A meta‐analysis Muhammad Huzaifa Ahmed Khan Muneeb Khawar Asad Ullah Farooq Azooba Khalid Syed Muhammad Ahsan M. Hamza Naseer Awan Muhammad Soban Nisar Asim Elahi Muhammad Aqib Faizan Iqra Shahid Abdullah Munir Ahmed Faseeh Haider Rejina Chhetri Precision Medical Sciences Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement: A meta‐analysis Muhammad Huzaifa Ahmed Khan Muneeb Khawar Asad Ullah Farooq Azooba Khalid Syed Muhammad Ahsan M. Hamza Naseer Awan Muhammad Soban Nisar Asim Elahi Muhammad Aqib Faizan Iqra Shahid Abdullah Munir Ahmed Faseeh Haider Rejina Chhetri Precision Medical Sciences Abstract Bicuspid aortic valve (BAV) is a common congenital anomaly leading to early aortic stenosis. Although transcatheter aortic valve replacement (TAVR) offers a less invasive treatment for BAV stenosis, sex‐specific outcome data are scarce. This study evaluates clinical outcomes after TAVR by sex in BAV patients. A systematic literature search was performed across PubMed, ClinicalTrials.gov , and Cochrane CENTRAL to identify relevant English‐language randomized controlled trials and observational studies. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using fixed‐ or random‐effects models based on heterogeneity. Statistical significance was set at p < .05, and heterogeneity was assessed using the I 2 statistic. Analyses were performed with Review Manager Version 5.3. Four observational studies comprising 7585 patients met inclusion criteria. Males had a higher incidence of acute kidney injury (AKI) (RR = 1.33; 95% CI: 1.13–1.57; p = .0008) and acute myocardial infarction (MI) (RR = 2.18; 95% CI: 1.54–3.07; p = .00001), but a lower risk of in‐hospital mortality (RR = 0.71; 95% CI: 0.51–0.99; p = .04), stroke (RR = 0.70; 95% CI: 0.50–0.95; p = .02), and bleeding (RR = 0.79; 95% CI: 0.63–0.98; p = .03) compared to females. No statistically significant differences were observed in one‐year mortality (RR = 1.08; 95% CI: 0.58–2.03; p = .81), 30‐day mortality (RR = 1.18; 95% CI: 0.51–2.75; p = .69), or arrhythmia (RR = 0.83; 95% CI: 0.52–1.33; p = .45). Males had increased risks of AKI and MI, while females experienced higher in‐hospital mortality, stroke, and bleeding. These findings, derived from a limited number of retrospective observational studies, are hypothesis‐generating and highlight the need for sex‐specific risk stratification and further prospective research to confirm these patterns and guide clinical practice. 10.1002/prm2.70021 http://creativecommons.org/licenses/by/4.0/ |
| title | Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement: A meta‐analysis |
| topic | Precision Medical Sciences |
| url | https://onlinelibrary.wiley.com/doi/10.1002/prm2.70021 |