Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2024
|
| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/pro6.1221 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1867014493221945344 |
|---|---|
| author | Kazuya Takeda Rei Umezawa Takaya Yamamoto Noriyoshi Takahashi Yu Suzuki Keita Kishida So Omata Keiichi Jingu |
| author_facet | Kazuya Takeda Rei Umezawa Takaya Yamamoto Noriyoshi Takahashi Yu Suzuki Keita Kishida So Omata Keiichi Jingu Kazuya Takeda Rei Umezawa Takaya Yamamoto Noriyoshi Takahashi Yu Suzuki Keita Kishida So Omata Keiichi Jingu |
| collection | Wiley Open Access |
| contents | Lymphocytopenia following adjuvant radiotherapy for breast cancer Kazuya Takeda Rei Umezawa Takaya Yamamoto Noriyoshi Takahashi Yu Suzuki Keita Kishida So Omata Keiichi Jingu Precision Radiation Oncology AbstractObjectiveWe retrospectively analyzed breast cancer patients who received adjuvant radiotherapy to determine the incidence of lymphocytopenia and its risk factors.MethodsWe reviewed 812 patients with breast cancer who received postoperative radiotherapy. Patients were divided into two groups based on the use of chemotherapy, and a generalized linear regression model was used to explore predictive factors for grade 2 or higher lymphocytopenia. We also examined the effect of lymphocytopenia on overall survival.ResultsGrade 2 or higher lymphocytopenia was observed in 19.4% of patients who did not receive chemotherapy and 45.1% of patients who received chemotherapy. In multivariate analysis, bilateral disease, regional lymph node irradiation, and baseline lymphocytopenia were associated with lymphocytopenia in patients who did not receive cytotoxic chemotherapy. Regional lymph node irradiation, baseline lymphocytopenia, use of antimetabolites, and use of molecular‐targeted agents were associated with lymphocytopenia in patients treated with chemotherapy. In the survival analysis, lymphocytopenia was associated with worse overall survival only in patients treated with cytotoxic chemotherapy (p = 0.039), and not in patients who did not receive chemotherapy (p = 0.77).ConclusionThe analysis revealed the incidence and risk factors of lymphocytopenia after postoperative radiotherapy in patients with breast cancer. 10.1002/pro6.1221 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1002/pro6.1221 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_pro6_1221 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Lymphocytopenia following adjuvant radiotherapy for breast cancer Kazuya Takeda Rei Umezawa Takaya Yamamoto Noriyoshi Takahashi Yu Suzuki Keita Kishida So Omata Keiichi Jingu Precision Radiation Oncology Lymphocytopenia following adjuvant radiotherapy for breast cancer Kazuya Takeda Rei Umezawa Takaya Yamamoto Noriyoshi Takahashi Yu Suzuki Keita Kishida So Omata Keiichi Jingu Precision Radiation Oncology AbstractObjectiveWe retrospectively analyzed breast cancer patients who received adjuvant radiotherapy to determine the incidence of lymphocytopenia and its risk factors.MethodsWe reviewed 812 patients with breast cancer who received postoperative radiotherapy. Patients were divided into two groups based on the use of chemotherapy, and a generalized linear regression model was used to explore predictive factors for grade 2 or higher lymphocytopenia. We also examined the effect of lymphocytopenia on overall survival.ResultsGrade 2 or higher lymphocytopenia was observed in 19.4% of patients who did not receive chemotherapy and 45.1% of patients who received chemotherapy. In multivariate analysis, bilateral disease, regional lymph node irradiation, and baseline lymphocytopenia were associated with lymphocytopenia in patients who did not receive cytotoxic chemotherapy. Regional lymph node irradiation, baseline lymphocytopenia, use of antimetabolites, and use of molecular‐targeted agents were associated with lymphocytopenia in patients treated with chemotherapy. In the survival analysis, lymphocytopenia was associated with worse overall survival only in patients treated with cytotoxic chemotherapy (p = 0.039), and not in patients who did not receive chemotherapy (p = 0.77).ConclusionThe analysis revealed the incidence and risk factors of lymphocytopenia after postoperative radiotherapy in patients with breast cancer. 10.1002/pro6.1221 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Lymphocytopenia following adjuvant radiotherapy for breast cancer |
| topic | Precision Radiation Oncology |
| url | https://onlinelibrary.wiley.com/doi/10.1002/pro6.1221 |