Imagen de Portada

Unraveling paralog‐specific Notch signaling through thermodynamics of ternary complex formation and transcriptional activation of chimeric receptors

Fuente: Wiley Open Access

Guardado en:

Detalles Bibliográficos
Autores principales:	Kristen M. Ramsey, Doug Barrick
Formato:	Artículo Open Access
Publicado:	Wiley 2024
Materias:	Protein Science
Acceso en línea:	Acceder al recurso
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

The importance of input sequence set to consensus‐derived proteins and their relationship to reconstructed ancestral proteins
por: Charlotte Nixon, et al.
Publicado: (2024)

Guanidinylation of the cold shock protein YB‐1: Molecular basis, structural changes and Notch‐3 receptor binding
por: Anna Leitz, et al.
Publicado: (2025)

Structural and functional insights into transcription activation of the essential LysR‐type transcriptional regulators
por: Jing Shi, et al.
Publicado: (2024)

Elaboration of the Homer1 recognition landscape reveals incomplete divergence of paralogous EVH1 domains
por: Avinoam Singer, et al.
Publicado: (2024)

Stability and cooperativity in chimeric de novo TIM barrels via quarter swapping
por: Oscar Rodríguez‐Meza, et al.
Publicado: (2026)

Hierarchy in regulator interactions with distant transcriptional activation domains empowers rheostatic regulation
por: Amanda D. Due, et al.
Publicado: (2025)

Growth hormone receptor antagonists, GHA2 and GHA3, with dual activity against the human and mouse receptor
por: Yue Wang, et al.
Publicado: (2025)

Efficient and rapid isolation of native AMPA receptor complexes for cryo‐ EM
por: Jumi Park, et al.
Publicado: (2026)

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities
por: Fatemeh Taherian, et al.
Publicado: (2025)

Design and characterization of calprotectin tetramerization variants for probing the role of oligomerization in receptor activation
por: Velia Garcia, et al.
Publicado: (2025)

Vesiculin reveals the role of the IGF2 C‐domain in receptor specificity within the insulin– IGF system
por: Karolína Mrzílková, et al.
Publicado: (2026)

iLight2: A near‐infrared optogenetic tool for gene transcription with low background activation
por: Mikhail Baloban, et al.
Publicado: (2024)

Constitutive activity of the sweet taste receptor: Heavy water sweetness and beyond
por: Annalisa Pastore, et al.
Publicado: (2025)

Integrative motif conservation, entropy, and hotspot analysis uncovers class‐specific transmembrane architecture in human olfactory receptors
por: Nidhi Dubey, et al.
Publicado: (2026)

Protein‐tags and their fragments as potent inhibitors of enzymes: Structure of the ternary complex of phosphopantetheine adenylyltransferase from Enterobacter spp. with tag‐peptides and phosphonoacetic acid at 2.20 Å resolution
por: Nabeel Ahmad, et al.
Publicado: (2025)

Activity‐restoring mutations in the histamine H 3 receptor increase constitutive activity and reduce structural stability
por: Ami Nakajima, et al.
Publicado: (2025)

Probing effects of site‐specific aspartic acid isomerization on structure and stability of GB1 through chemical protein synthesis
por: Shelby L. Heath, et al.
Publicado: (2024)

The potent PHL4 transcription factor effector domain contains significant disorder
por: Blake D. Fonda, et al.
Publicado: (2024)

Unlocking complexity through neutron scattering: Structure and dynamics of protein–polymer conjugates
por: Daniela Russo, et al.
Publicado: (2025)

Computational model predicts function of Rho‐GTPase binding for plexin receptor GAP activity on Rap1b via dynamic allosteric changes
por: Nisha Bhattarai, et al.
Publicado: (2025)

Functional thermodynamics govern the ligand binding to human cytosolic transport proteins
por: Sebastian Michler, et al.
Publicado: (2026)

Engineering G protein‐coupled receptors for stabilization
por: João Paulo L. Velloso, et al.
Publicado: (2024)

Insights on the G protein‐coupled receptor helix 8 solution structure and orientation using a neurotensin receptor 1 peptide
por: James B. Bower, et al.
Publicado: (2024)

HSPA8 regulates microtubule detyrosination through direct interaction with the VASH1 ‐ SVBP complex
por: Hao Guo, et al.
Publicado: (2026)

The mineralocorticoid receptor forms higher order oligomers upon DNA binding
por: Gregory Fettweis, et al.
Publicado: (2024)

Weak, specific chemical interactions dictate barnase stability in diverse cellular environments
por: Ume Tahir, et al.
Publicado: (2025)

Rational evolution for altering the ligand preference of estrogen receptor alpha
por: Roy Eerlings, et al.
Publicado: (2024)

Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure
por: Antonio J. Rua, et al.
Publicado: (2024)

Structural insights into the interaction between testis‐specific Y‐encoded‐like protein 5 and ubiquitin‐specific protease 7
por: Marine Ancia, et al.
Publicado: (2025)

Amino acid variability at W194 of Staphylococcus aureus sortase A alters nucleophile specificity
por: Hanna M. Kodama, et al.
Publicado: (2024)

Optimized histidine‐specific isotopic labeling in proteins overproduced in Escherichia coli
por: Rosalie L. Dohmen, et al.
Publicado: (2026)

Structural and functional validation of a highly specific Smurf2 inhibitor
por: Tanner M. Tessier, et al.
Publicado: (2024)

Unraveling the underlying mechanisms of reduced amyloidogenic properties in human calcitonin via double mutations
por: Yu‐Pei Chang, et al.
Publicado: (2024)

Unraveling the molecular grammar and the structural transitions underlying the fibrillation of a viral fibrillogenic domain
por: Frank Gondelaud, et al.
Publicado: (2025)

Unraveling ShuA detergent‐induced colloidal behavior in solution: A comprehensive SEC‐MALS, SAXS, and SANS study
por: A. Pozza, et al.
Publicado: (2025)

An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo
por: Jarrett J. Adams, et al.
Publicado: (2025)

Thiol post‐translational modifications modulate allosteric regulation of the OpcA – G6PDH complex through conformational gate control
por: Hoshin Kim, et al.
Publicado: (2026)

Diversity of FAAL enzymes and prediction of their substrate specificity using FAALPred
por: Anne Liong, et al.
Publicado: (2026)

Intramolecular epistasis correlates with divergence of specificity in promiscuous and bifunctional NSAR/OSBS enzymes
por: Dat P. Truong, et al.
Publicado: (2025)

Viral envelope proteins fused to multiple distinct fluorescent reporters to probe receptor binding
por: Ilhan Tomris, et al.
Publicado: (2024)