Copertina

Unraveling the underlying mechanisms of reduced amyloidogenic properties in human calcitonin via double mutations

Fuente: Wiley Open Access

Salvato in:

Dettagli Bibliografici
Autori principali:	Yu‐Pei Chang, Pei‐Chun Pan, Ling‐Hsien Tu
Natura:	Artículo Open Access
Pubblicazione:	Wiley 2024
Soggetti:	Protein Science
Accesso online:	Acceder al recurso
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi

Activity‐restoring mutations in the histamine H 3 receptor increase constitutive activity and reduce structural stability
di: Ami Nakajima, et al.
Pubblicazione: (2025)

Assessing the mechanism of fast‐cycling cancer‐associated mutations of Rac1 small Rho GTPase
di: Angela Parise, et al.
Pubblicazione: (2024)

Molecular mechanisms for DNA methylation defects induced by ICF syndrome‐linked mutations in DNMT3B
di: Chao‐Cheng Cho, et al.
Pubblicazione: (2024)

Second‐order allosteric control as a mechanism for compensatory mutations in B‐cell translocation gene 2
di: Nicholas J. Ose, et al.
Pubblicazione: (2025)

Functional reconstitution of bacterial ESCRT‐III protein PspA identifies key regions in membrane binding and remodeling
di: Samuel Herianto, et al.
Pubblicazione: (2025)

Unraveling the molecular grammar and the structural transitions underlying the fibrillation of a viral fibrillogenic domain
di: Frank Gondelaud, et al.
Pubblicazione: (2025)

Understanding the stability landscape of LbCas12a by deep analysis of stabilizing mutations and mutation combinations
di: Jiajun Dong, et al.
Pubblicazione: (2025)

In silico peptide self‐assembly reveals the importance of N‐terminal motifs and the inhibition mechanism of the mutation L38M in α ‐synuclein fibrillation
di: Van T. T. Nguyen, et al.
Pubblicazione: (2026)

Complete combinatorial mutational enumeration of a protein functional site enables sequence‐landscape mapping and identifies highly‐mutated variants that retain activity
di: Mireia Solà Colom, et al.
Pubblicazione: (2024)

Computational studies on the functional and structural impact of pathogenic mutations in enzymes
di: Upeksha C. Dissanayake, et al.
Pubblicazione: (2025)

Genetic mutations disrupt the coordinated mode of tyrosinase's intra‐melanosomal domain
di: Sarah Toay, et al.
Pubblicazione: (2025)

Role of associated water in stabilizing human γ‐D crystallin under crowded eye lens conditions
di: Bhupendra Singh, et al.
Pubblicazione: (2025)

Concentration‐dependent mutational scanning probes the cellular folding landscape of α‐synuclein in yeast
di: Daeun Noh, et al.
Pubblicazione: (2026)

Molecular mechanics studies of factors affecting overall rate in cascade reactions: Multi‐enzyme colocalization and environment
di: Shivansh Kaushik, et al.
Pubblicazione: (2024)

StabLyzeGraph : High‐throughput screening of combinatorial mutations using graph neural networks
di: Muhammad Waqas, et al.
Pubblicazione: (2026)

Enriching stabilizing mutations through automated analysis of molecular dynamics simulations using BoostMut
di: Kerlen T. Korbeld, et al.
Pubblicazione: (2025)

Defining short linear motif binding determinants by phage display‐based deep mutational scanning
di: Caroline Benz, et al.
Pubblicazione: (2025)

An in silico framework to visualize how cancer‐associated mutations influence structural plasticity of the chemokine receptor CCR3
di: Evan J. van Aalst, et al.
Pubblicazione: (2024)

Correction to “The transmission of mutation effects in a multiprotein machine: A comprehensive metadynamics study of the cardiac thin filament”
Pubblicazione: (2024)

MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross‐seeding ability
di: Anukool A. Bhopatkar, et al.
Pubblicazione: (2024)

The structural influence of the oncogenic driver mutation N642H in the STAT5B SH2 domain
di: Liam Haas‐Neill, et al.
Pubblicazione: (2024)

An ALS ‐associated mutation in the C‐terminal α‐helix of TDP ‐43 uncouples condensate formation and amyloid assembly
di: Emily J. Byrd, et al.
Pubblicazione: (2026)

Production of human cathepsins using Expi293™ mammalian cell expression system for off‐target activity of cysteine protease inhibitor screening
di: Zoe Turner, et al.
Pubblicazione: (2025)

The pathogenic E139D mutation stabilizes a non‐canonical active state of the multi‐domain phosphatase SHP2
di: Anne E. van Vlimmeren, et al.
Pubblicazione: (2025)

Backbone double‐mutant cycle analysis quantifies hydrogen‐bond energies in proteins
di: Haoliang Zheng, et al.
Pubblicazione: (2026)

Unraveling paralog‐specific Notch signaling through thermodynamics of ternary complex formation and transcriptional activation of chimeric receptors
di: Kristen M. Ramsey, et al.
Pubblicazione: (2024)

Molecular mechanism of Fe3+ binding inhibition to Vibrio metschnikovii ferric ion‐binding protein, FbpA, by rosmarinic acid and its hydrolysate, danshensu
di: Peng Lu, et al.
Pubblicazione: (2024)

Unraveling ShuA detergent‐induced colloidal behavior in solution: A comprehensive SEC‐MALS, SAXS, and SANS study
di: A. Pozza, et al.
Pubblicazione: (2025)

Biophysical insights into the dimer formation of human Sirtuin 2
di: Noa Suzuki, et al.
Pubblicazione: (2024)

Unperturbed hydration structure involves ADP recognition in the N‐terminal domain of human heat shock protein 90α
di: Yu Hirano, et al.
Pubblicazione: (2026)

The double histone fold: Structure, functional implications across the tree of life and relevance to protein design
di: Anna Ranaudo, et al.
Pubblicazione: (2026)

An improved variant of tobacco etch virus (TEV) protease that does not need reducing agents
di: Stella M. Davis, et al.
Pubblicazione: (2025)

Toxic mechanisms of amyloid oligomers and therapeutic strategies
di: Magdalena I. Ivanova, et al.
Pubblicazione: (2026)

Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7
di: Nurgül Bilgin, et al.
Pubblicazione: (2024)

Identifying and quantifying membrane interactions of the protein human cis ‐prenyltransferase
di: Duncan M. Boren, et al.
Pubblicazione: (2025)

Beyond olfaction: New insights into human odorant binding proteins
di: Mifen Chen, et al.
Pubblicazione: (2026)

Revisiting the structure of UBR box from human UBR6
di: Bokyung Kim, et al.
Pubblicazione: (2025)

Unveiling nuclear localization signals in human arginine deiminase proteins
di: José L. Neira, et al.
Pubblicazione: (2026)

Amino acid sequence encodes protein abundance shaped by protein stability at reduced synthesis cost
di: Filip Buric, et al.
Pubblicazione: (2024)

Molecular mechanism of Mad2 conformational conversion promoted by the Mad2 ‐interaction motif of Cdc20
di: Conny W. H. Yu, et al.
Pubblicazione: (2025)