MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross‐seeding ability
Fuente:
Wiley Open Access
Saved in:
| Main Authors: | Anukool A. Bhopatkar, Nemil Bhatt, Md Anzarul Haque, Rhea Xavier, Leiana Fung, Cynthia Jerez, Rakez Kayed |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2024
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
APOE‐relevant tau oligomer polymorphs differentially impair synaptic functioning
by: Naomi Moreno, et al.
Published: (2025)
by: Naomi Moreno, et al.
Published: (2025)
Traumatic brain injury derived pathological tau polymorphs induce the distinct propagation pattern and neuroinflammatory response
by: Nemil Bhatt, et al.
Published: (2025)
by: Nemil Bhatt, et al.
Published: (2025)
Toxic Interplay Between Small Dipeptide Protein Repeats and Tau in Tauopathies
by: Nemil Bhatt, et al.
Published: (2024)
by: Nemil Bhatt, et al.
Published: (2024)
Unveiling the synaptic selectivity of tau oligomers: implications for targeted therapeutics in tauopathies
by: Shrinath Kadamangudi, et al.
Published: (2025)
by: Shrinath Kadamangudi, et al.
Published: (2025)
Nuclear HMGB1 Loss in the Aging Brain Triggers cGAS‐STING Pathway and Neuroinflammation that Contributes to Senescence and Cognitive Decline in Tauopathies
by: Sagar Gaikwad, et al.
Published: (2024)
by: Sagar Gaikwad, et al.
Published: (2024)
Novel GH115 xylan α‐1,2‐glucuronidases with distinct preferences for xylan‐derived oligomers and polymers
by: Savvina Leontakianakou, et al.
Published: (2026)
by: Savvina Leontakianakou, et al.
Published: (2026)
Toxic mechanisms of amyloid oligomers and therapeutic strategies
by: Magdalena I. Ivanova, et al.
Published: (2026)
by: Magdalena I. Ivanova, et al.
Published: (2026)
The mineralocorticoid receptor forms higher order oligomers upon DNA binding
by: Gregory Fettweis, et al.
Published: (2024)
by: Gregory Fettweis, et al.
Published: (2024)
In vitro, cellular and in vivo studies of amyloid oligomers structure and toxicity: Challenges and advances
by: Magdalena I. Ivanova, et al.
Published: (2026)
by: Magdalena I. Ivanova, et al.
Published: (2026)
Structural and morphological dynamics of “on‐path” and “off‐path” oligomers of human islet amyloid polypeptide
by: Daniel Warren, et al.
Published: (2026)
by: Daniel Warren, et al.
Published: (2026)
Specific inhibition of α‐synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS
by: Laurène Adam, et al.
Published: (2024)
by: Laurène Adam, et al.
Published: (2024)
A Common Epitope in p53 and Tau Protein Aggregates
by: David Lynch, et al.
Published: (2024)
by: David Lynch, et al.
Published: (2024)
Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain
by: Caldes, T, et al.
Published: (2002)
by: Caldes, T, et al.
Published: (2002)
Ion mobility mass spectrometry unveils conformational effects of drug lead EPI ‐001 on the intrinsically disordered N ‐terminal domain of the androgen receptor
by: Ikhlas M. M. Ahmed, et al.
Published: (2024)
by: Ikhlas M. M. Ahmed, et al.
Published: (2024)
Understanding the stability landscape of LbCas12a by deep analysis of stabilizing mutations and mutation combinations
by: Jiajun Dong, et al.
Published: (2025)
by: Jiajun Dong, et al.
Published: (2025)
Phage lysis protein Lys acts as a wedge to block MurJ conformational changes.
by: Kohga, Hidetaka, et al.
Published: (2025)
by: Kohga, Hidetaka, et al.
Published: (2025)
Complete combinatorial mutational enumeration of a protein functional site enables sequence‐landscape mapping and identifies highly‐mutated variants that retain activity
by: Mireia Solà Colom, et al.
Published: (2024)
by: Mireia Solà Colom, et al.
Published: (2024)
Classifying protein kinase conformations with machine learning
by: Ivan Reveguk, et al.
Published: (2024)
by: Ivan Reveguk, et al.
Published: (2024)
Computational studies on the functional and structural impact of pathogenic mutations in enzymes
by: Upeksha C. Dissanayake, et al.
Published: (2025)
by: Upeksha C. Dissanayake, et al.
Published: (2025)
Viral envelope proteins fused to multiple distinct fluorescent reporters to probe receptor binding
by: Ilhan Tomris, et al.
Published: (2024)
by: Ilhan Tomris, et al.
Published: (2024)
Genetic mutations disrupt the coordinated mode of tyrosinase's intra‐melanosomal domain
by: Sarah Toay, et al.
Published: (2025)
by: Sarah Toay, et al.
Published: (2025)
Intrinsic conformational equilibria position arrestin‐2 for activation
by: Tucker J. Shriver, et al.
Published: (2026)
by: Tucker J. Shriver, et al.
Published: (2026)
Transmembrane conformation of the envelope protein of an alpha coronavirus, NL63
by: Iva Sučec, et al.
Published: (2024)
by: Iva Sučec, et al.
Published: (2024)
Sizes, conformational fluctuations, and SAXS profiles for intrinsically disordered proteins
by: Mauro L. Mugnai, et al.
Published: (2025)
by: Mauro L. Mugnai, et al.
Published: (2025)
Concentration‐dependent mutational scanning probes the cellular folding landscape of α‐synuclein in yeast
by: Daeun Noh, et al.
Published: (2026)
by: Daeun Noh, et al.
Published: (2026)
Unraveling the underlying mechanisms of reduced amyloidogenic properties in human calcitonin via double mutations
by: Yu‐Pei Chang, et al.
Published: (2024)
by: Yu‐Pei Chang, et al.
Published: (2024)
Multiple disulfide‐bonded states confer extensive conformational diversity in fibrinogen
by: Aster E. Pijning, et al.
Published: (2026)
by: Aster E. Pijning, et al.
Published: (2026)
ConforFold recovers alternative protein conformations beyond MSA subsampling
by: Raulia Syrlybaeva, et al.
Published: (2026)
by: Raulia Syrlybaeva, et al.
Published: (2026)
Kunitz‐type trypsin inhibitor from durian (Durio zibethinus) employs a distinct loop for trypsin inhibition
by: Peerapon Deetanya, et al.
Published: (2024)
by: Peerapon Deetanya, et al.
Published: (2024)
Cripto‐1 acts as a molecular bridge linking nodal to ALK4 via distinct structural domains
by: Kit‐Yee Chu, et al.
Published: (2025)
by: Kit‐Yee Chu, et al.
Published: (2025)
StabLyzeGraph : High‐throughput screening of combinatorial mutations using graph neural networks
by: Muhammad Waqas, et al.
Published: (2026)
by: Muhammad Waqas, et al.
Published: (2026)
Assessing the mechanism of fast‐cycling cancer‐associated mutations of Rac1 small Rho GTPase
by: Angela Parise, et al.
Published: (2024)
by: Angela Parise, et al.
Published: (2024)
Enriching stabilizing mutations through automated analysis of molecular dynamics simulations using BoostMut
by: Kerlen T. Korbeld, et al.
Published: (2025)
by: Kerlen T. Korbeld, et al.
Published: (2025)
Defining short linear motif binding determinants by phage display‐based deep mutational scanning
by: Caroline Benz, et al.
Published: (2025)
by: Caroline Benz, et al.
Published: (2025)
Cryo‐ EM reveals an ensemble of cytochrome P450 reductase conformations in solution
by: Galina I. Lepesheva, et al.
Published: (2026)
by: Galina I. Lepesheva, et al.
Published: (2026)
The effects of biological crowders on fibrillization, structure, diffusion, and conformational dynamics of α‐synuclein
by: Sina Heravi, et al.
Published: (2024)
by: Sina Heravi, et al.
Published: (2024)
Exploring the conformational changes of the Munc18‐1 /syntaxin 1a complex
by: Ioanna Stefani, et al.
Published: (2024)
by: Ioanna Stefani, et al.
Published: (2024)
Molecular mechanisms for DNA methylation defects induced by ICF syndrome‐linked mutations in DNMT3B
by: Chao‐Cheng Cho, et al.
Published: (2024)
by: Chao‐Cheng Cho, et al.
Published: (2024)
Activity‐restoring mutations in the histamine H 3 receptor increase constitutive activity and reduce structural stability
by: Ami Nakajima, et al.
Published: (2025)
by: Ami Nakajima, et al.
Published: (2025)
Second‐order allosteric control as a mechanism for compensatory mutations in B‐cell translocation gene 2
by: Nicholas J. Ose, et al.
Published: (2025)
by: Nicholas J. Ose, et al.
Published: (2025)
Similar Items
-
APOE‐relevant tau oligomer polymorphs differentially impair synaptic functioning
by: Naomi Moreno, et al.
Published: (2025) -
Traumatic brain injury derived pathological tau polymorphs induce the distinct propagation pattern and neuroinflammatory response
by: Nemil Bhatt, et al.
Published: (2025) -
Toxic Interplay Between Small Dipeptide Protein Repeats and Tau in Tauopathies
by: Nemil Bhatt, et al.
Published: (2024) -
Unveiling the synaptic selectivity of tau oligomers: implications for targeted therapeutics in tauopathies
by: Shrinath Kadamangudi, et al.
Published: (2025) -
Nuclear HMGB1 Loss in the Aging Brain Triggers cGAS‐STING Pathway and Neuroinflammation that Contributes to Senescence and Cognitive Decline in Tauopathies
by: Sagar Gaikwad, et al.
Published: (2024)