Cover Image

Mispacking of the F87 sidechain drives aggregation‐promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer

Fuente: Wiley Open Access

Saved in:

Bibliographic Details
Main Authors:	Xun Sun, James A. Ferguson, Ke Yang, Robyn L. Stanfield, H. Jane Dyson, Peter E. Wright
Format:	Artículo Open Access
Published:	Wiley 2024
Subjects:	Protein Science
Online Access:	Acceder al recurso
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Recognizing amino acid sidechains in a medium‐resolution cryo‐electron density map
by: Dibyendu Mondal, et al.
Published: (2025)

Ultrasonication‐induced in vitro formation of transthyretin mature amyloid fibrils at neutral pH
by: Keisuke Yuzu, et al.
Published: (2026)

Lysine carbamoylation during urea denaturation remodels the energy landscape of human transthyretin dissociation linked to unfolding
by: Marcus Jäger, et al.
Published: (2025)

Sizes, conformational fluctuations, and SAXS profiles for intrinsically disordered proteins
by: Mauro L. Mugnai, et al.
Published: (2025)

On the relationship between efficiency and cooperativity in multi‐subunit molecular machines
by: Miki Ben‐Maimon, et al.
Published: (2026)

Molecular mechanism of Mad2 conformational conversion promoted by the Mad2 ‐interaction motif of Cdc20
by: Conny W. H. Yu, et al.
Published: (2025)

Biological and structural characterization of the Type 3 fimbrial subunit MrkA from Klebsiella pneumoniae
by: Valentina Monaci, et al.
Published: (2025)

The subunit composition of the mammalian Mediator complex is not conserved in all vertebrates: Insights from evolutionary plasticity of fish genomes
by: Radka Symonová, et al.
Published: (2026)

Impact of local unfolding fluctuations on the evolution of regional sequence preferences in proteins
by: Keila Voortman‐Sheetz, et al.
Published: (2025)

Phage lysis protein Lys acts as a wedge to block MurJ conformational changes.
by: Kohga, Hidetaka, et al.
Published: (2025)

Guide to the structural characterization of protein aggregates and amyloid fibrils by CD spectroscopy
by: József Kardos, et al.
Published: (2025)

Classifying protein kinase conformations with machine learning
by: Ivan Reveguk, et al.
Published: (2024)

Intrinsic conformational equilibria position arrestin‐2 for activation
by: Tucker J. Shriver, et al.
Published: (2026)

A pressure‐jump EPR system to monitor millisecond conformational exchange rates of spin‐labeled proteins
by: Julian D. Grosskopf, et al.
Published: (2024)

Transmembrane conformation of the envelope protein of an alpha coronavirus, NL63
by: Iva Sučec, et al.
Published: (2024)

Competing chaperone pathways in α‐synuclein disaggregation and aggregation dynamics
by: Nicola K. Auld, et al.
Published: (2025)

Structural basis for nucleolin recognition of promoter G-quadruplex.
by: Chen, Luying, et al.
Published: (2025)

Engineered cyclodextrin-protein domain interface modulation and application in nanoscale delivery systems development for therapeutic proteins.
by: Wang, Qiyue, et al.
Published: (2025)

Multiple disulfide‐bonded states confer extensive conformational diversity in fibrinogen
by: Aster E. Pijning, et al.
Published: (2026)

ConforFold recovers alternative protein conformations beyond MSA subsampling
by: Raulia Syrlybaeva, et al.
Published: (2026)

Inhibition of tau aggregation by the CCT3 and CCT7 apical domains
by: Miki Ben‐Maimon, et al.
Published: (2025)

Cryo‐ EM reveals an ensemble of cytochrome P450 reductase conformations in solution
by: Galina I. Lepesheva, et al.
Published: (2026)

The effects of biological crowders on fibrillization, structure, diffusion, and conformational dynamics of α‐synuclein
by: Sina Heravi, et al.
Published: (2024)

Exploring the conformational changes of the Munc18‐1 /syntaxin 1a complex
by: Ioanna Stefani, et al.
Published: (2024)

Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains
by: Sherry Wong, et al.
Published: (2024)

Biophysical assessment of the molecular mechanisms of Tau aggregation and its role in Alzheimer's disease
by: Joshua T. Skrehot, et al.
Published: (2026)

Navigating infection by pathogenic spirochetes: The host‐bacteria interface at the atomic level
by: Libor Hejduk, et al.
Published: (2025)

AlphaFold2's training set powers its predictions of some fold‐switched conformations
by: Joseph W. Schafer, et al.
Published: (2025)

AggNet: Advancing protein aggregation analysis through deep learning and protein language model
by: Wenjia He, et al.
Published: (2025)

Analysis of β‐C‐terminal salt bridges in T‐state hemoglobin by trapping tertiary conformations in silica gels
by: Naoya Shibayama
Published: (2025)

Two‐conformer equilibrium of maltose‐binding protein in the absence of ligand from residual dipolar coupling analysis
by: Yang Shen, et al.
Published: (2025)

The role of phospholipid saturation and composition in α‐synuclein aggregation and toxicity: A dual in vitro and in vivo approach
by: Aidan P. Holman, et al.
Published: (2025)

Amphipathic N-terminal helices drive MLKL-mediated necroptosis through an antimicrobial peptide-like mechanism across evolution.
by: Tian, Xin, et al.
Published: (2026)

A high‐sensitivity stopped‐flow EPR system to monitor millisecond conformational kinetics in spin‐labeled proteins
by: Alexander M. Garces, et al.
Published: (2025)

Cleaved versus Uncleaved: How furin cleavage reshapes the conformational landscape of SARS ‐ CoV ‐2 spike
by: Natesan Mani, et al.
Published: (2025)

MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross‐seeding ability
by: Anukool A. Bhopatkar, et al.
Published: (2024)

Aggrescan4D: A comprehensive tool for pH‐dependent analysis and engineering of protein aggregation propensity
by: Mateusz Zalewski, et al.
Published: (2024)

copick: An open dataset interface and toolkit for collaborative annotation and analysis of cryo‐electron tomography data
by: Utz Heinrich Ermel, et al.
Published: (2026)

Accelerated amyloid fibril formation at the interface of liquid–liquid phase‐separated droplets by depletion interactions
by: Keiichi Yamaguchi, et al.
Published: (2025)

Phosphinate pseudopeptide enhances binding free energy in HIV ‐1 protease by driving flap closure and suppressing global flexibility
by: Yuxin Xie, et al.
Published: (2026)