Integrating molecular dynamics simulation with small‐ and wide‐angle X‐ray scattering to unravel the flexibility, antigen‐blocking, and protease‐restoring functions in a hindrance‐based pro‐antibody
Fuente:
Wiley Open Access
Enregistré dans:
| Auteurs principaux: | Jun Min Liao, Shih‐Ting Hong, Yeng‐Tseng Wang, Yi‐An Cheng, Kai‐Wen Ho, Shu‐Ing Toh, Orion Shih, U‐Ser Jeng, Ping‐Chiang Lyu, I‐Chen Hu, Ming‐Yii Huang, Chin‐Yuan Chang, Tian‐Lu Cheng |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2024
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
Universal paratope–epitope interaction patterns in antibody–antigen structures
par: Marta A. S. Perez, et autres
Publié: (2025)
par: Marta A. S. Perez, et autres
Publié: (2025)
HAIRpred : Prediction of human antibody interacting residues in an antigen from its primary structure
par: Ruchir Sahni, et autres
Publié: (2025)
par: Ruchir Sahni, et autres
Publié: (2025)
A comparison of antibody–antigen complex sequence‐to‐structure prediction methods and their systematic biases
par: Katherine Maia McCoy, et autres
Publié: (2024)
par: Katherine Maia McCoy, et autres
Publié: (2024)
Phosphinate pseudopeptide enhances binding free energy in HIV ‐1 protease by driving flap closure and suppressing global flexibility
par: Yuxin Xie, et autres
Publié: (2026)
par: Yuxin Xie, et autres
Publié: (2026)
Discovery of broadly‐neutralizing antibodies against brown recluse spider and Gadim scorpion sphingomyelinases using consensus toxins as antigens
par: Esperanza Rivera‐de‐Torre, et autres
Publié: (2024)
par: Esperanza Rivera‐de‐Torre, et autres
Publié: (2024)
Structure of the chromoprotein ovorubin from the golden apple snail ( Pomacea canaliculata )
par: Patcharin Wilasluck, et autres
Publié: (2025)
par: Patcharin Wilasluck, et autres
Publié: (2025)
Structural basis for uPAR binding to an antibody developed for targeted cancer therapy. Mechanistic insights into flexibility, ligand recognition, and molecular imaging
par: Rex F. Anane, et autres
Publié: (2026)
par: Rex F. Anane, et autres
Publié: (2026)
Interplay between protease and reverse transcriptase dimerization in a model HIV‐1 polyprotein
par: Brisa Caroline Alves Chagas, et autres
Publié: (2024)
par: Brisa Caroline Alves Chagas, et autres
Publié: (2024)
An improved variant of tobacco etch virus (TEV) protease that does not need reducing agents
par: Stella M. Davis, et autres
Publié: (2025)
par: Stella M. Davis, et autres
Publié: (2025)
Structure‐based development of a canine TNF‐α‐specific antibody using adalimumab as a template
par: Cheng‐Chung Lee, et autres
Publié: (2024)
par: Cheng‐Chung Lee, et autres
Publié: (2024)
An open axial channel of the AAA ClpXP protease enhances degradation of specific classes of protein substrates
par: Yifei Lyu, et autres
Publié: (2025)
par: Yifei Lyu, et autres
Publié: (2025)
Accessing intractable, phosphorylated intrinsically disordered proteins via a protease‐cleavable inclusion body tag
par: Cat Hoang Vesely, et autres
Publié: (2026)
par: Cat Hoang Vesely, et autres
Publié: (2026)
Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease
par: Clauber H. S. da Costa, et autres
Publié: (2025)
par: Clauber H. S. da Costa, et autres
Publié: (2025)
Structural basis for dimerization, catalytic regulation, and substrate selectivity of the chloroplast S9D CGEP protease in Arabidopsis thaliana
par: Jacqueline J. Ehrlich, et autres
Publié: (2026)
par: Jacqueline J. Ehrlich, et autres
Publié: (2026)
Design of a water‐soluble CD20 antigen with computational epitope scaffolding
par: Zhiyuan Yao, et autres
Publié: (2025)
par: Zhiyuan Yao, et autres
Publié: (2025)
Phage lysis protein Lys acts as a wedge to block MurJ conformational changes.
par: Kohga, Hidetaka, et autres
Publié: (2025)
par: Kohga, Hidetaka, et autres
Publié: (2025)
Structural insights into the interaction between testis‐specific Y‐encoded‐like protein 5 and ubiquitin‐specific protease 7
par: Marine Ancia, et autres
Publié: (2025)
par: Marine Ancia, et autres
Publié: (2025)
Data‐driven evaluation of suitable immunogens for improved antibody selection
par: Katharina Waury, et autres
Publié: (2025)
par: Katharina Waury, et autres
Publié: (2025)
Production of human cathepsins using Expi293™ mammalian cell expression system for off‐target activity of cysteine protease inhibitor screening
par: Zoe Turner, et autres
Publié: (2025)
par: Zoe Turner, et autres
Publié: (2025)
AbDPP: Target‐oriented antibody design with pretraining and prior biological structure knowledge
par: Chenglei Yu, et autres
Publié: (2024)
par: Chenglei Yu, et autres
Publié: (2024)
Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains
par: Sherry Wong, et autres
Publié: (2024)
par: Sherry Wong, et autres
Publié: (2024)
Improving the solubility of single domain antibodies using VH‐like hallmark residues
par: Yuta Uto, et autres
Publié: (2025)
par: Yuta Uto, et autres
Publié: (2025)
Thermostability and binding properties of single‐chained Fv fragments derived from therapeutic antibodies
par: Takashi Tadokoro, et autres
Publié: (2024)
par: Takashi Tadokoro, et autres
Publié: (2024)
Tetravalent antibodies are more potent and efficacious erythropoiesis‐stimulating agents than erythropoietin in vivo
par: Jarrett J. Adams, et autres
Publié: (2026)
par: Jarrett J. Adams, et autres
Publié: (2026)
An alternative pocket for binding the N‐degrons by the UBR1 and UBR2 ubiquitin E3 ligases
par: Shih‐Ting Huang, et autres
Publié: (2025)
par: Shih‐Ting Huang, et autres
Publié: (2025)
A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin α‐dependent nuclear localization signals
par: Emily M. Cross, et autres
Publié: (2024)
par: Emily M. Cross, et autres
Publié: (2024)
A flexible, allosteric loop regulates protein activity and rewires electrostatics
par: Darex J. Vera‐Rodríguez, et autres
Publié: (2025)
par: Darex J. Vera‐Rodríguez, et autres
Publié: (2025)
Combining computational modeling and experimental library screening to affinity‐mature VEEV ‐neutralizing antibody F5
par: Christopher A. Sumner, et autres
Publié: (2025)
par: Christopher A. Sumner, et autres
Publié: (2025)
Structures of a synthetic antibody selected against and bound to the C‐terminal domain of Clostridium perfringens enterotoxin
par: Chinemerem P. Ogbu, et autres
Publié: (2025)
par: Chinemerem P. Ogbu, et autres
Publié: (2025)
Taming interleukin‐12: Engineering of bispecific antibody‐based IL‐12 mimetics with biased agonism capacities
par: Britta Lipinski, et autres
Publié: (2025)
par: Britta Lipinski, et autres
Publié: (2025)
Heat‐sterilizable antibody mimics designed on the cold shock protein scaffold from hyperthermophile Thermotoga maritima
par: Hiroshi Amesaka, et autres
Publié: (2024)
par: Hiroshi Amesaka, et autres
Publié: (2024)
An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors
par: Tony Eight Lin, et autres
Publié: (2024)
par: Tony Eight Lin, et autres
Publié: (2024)
FASTIA: A rapid and accessible platform for protein variant interaction analysis demonstrated with a single‐domain antibody
par: Ryo Matsunaga, et autres
Publié: (2025)
par: Ryo Matsunaga, et autres
Publié: (2025)
The role of the flexible loop region in the substrate binding and catalytic activity of malate dehydrogenases
par: Varuni K. Jamburuthugoda, et autres
Publié: (2025)
par: Varuni K. Jamburuthugoda, et autres
Publié: (2025)
Conformational flexibility associated with remote residues regulates the kinetic properties of glutamate dehydrogenase
par: Barsa Kanchan Jyotshna Godsora, et autres
Publié: (2025)
par: Barsa Kanchan Jyotshna Godsora, et autres
Publié: (2025)
Exploring protein functions from structural flexibility using CABS‐flex modeling
par: Chandran Nithin, et autres
Publié: (2024)
par: Chandran Nithin, et autres
Publié: (2024)
DSFworld: A flexible and precise tool to analyze differential scanning fluorimetry data
par: Taiasean Wu, et autres
Publié: (2024)
par: Taiasean Wu, et autres
Publié: (2024)
Insights into the diversity of CAHS protein function: Response to “Diversity in the protective role(s) of the conserved motif 1 from tardigrade cytoplasmic abundant heat soluble proteins during drying”
par: Donguk Kang, et autres
Publié: (2025)
par: Donguk Kang, et autres
Publié: (2025)
Self‐assembly of temperature‐responsive di‐block polypeptides functionalized with unnatural amino acids
par: Rotem Azulay, et autres
Publié: (2024)
par: Rotem Azulay, et autres
Publié: (2024)
Protein hydrolysates from quinoa ( Chenopodium quinoa Willd.) modulate macrophage polarization and the expression of surface antigen molecules
par: Restituto Tocmo, et autres
Publié: (2024)
par: Restituto Tocmo, et autres
Publié: (2024)
Documents similaires
-
Universal paratope–epitope interaction patterns in antibody–antigen structures
par: Marta A. S. Perez, et autres
Publié: (2025) -
HAIRpred : Prediction of human antibody interacting residues in an antigen from its primary structure
par: Ruchir Sahni, et autres
Publié: (2025) -
A comparison of antibody–antigen complex sequence‐to‐structure prediction methods and their systematic biases
par: Katherine Maia McCoy, et autres
Publié: (2024) -
Phosphinate pseudopeptide enhances binding free energy in HIV ‐1 protease by driving flap closure and suppressing global flexibility
par: Yuxin Xie, et autres
Publié: (2026) -
Discovery of broadly‐neutralizing antibodies against brown recluse spider and Gadim scorpion sphingomyelinases using consensus toxins as antigens
par: Esperanza Rivera‐de‐Torre, et autres
Publié: (2024)