Buchumschlag

Lysine carbamoylation during urea denaturation remodels the energy landscape of human transthyretin dissociation linked to unfolding

Fuente: Wiley Open Access

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Marcus Jäger, David E. Mortenson, Maziar S. Ardejani, Gabriel M. Kline, Maria T. Dendle, Nicholas L. Yan, Evan T. Powers, Martin Gruebele, Jeffery W. Kelly
Format:	Artículo Open Access
Veröffentlicht:	Wiley 2025
Schlagworte:	Protein Science
Online-Zugang:	Acceder al recurso
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge

Lysine acetylation modulates s‐OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling
von: Javaid Jabbar, et al.
Veröffentlicht: (2025)

Oxidative denaturation of Cu/Zn‐superoxide dismutase associated with neurodegenerative diseases
von: Moeno Yoshida, et al.
Veröffentlicht: (2025)

Ultrasonication‐induced in vitro formation of transthyretin mature amyloid fibrils at neutral pH
von: Keisuke Yuzu, et al.
Veröffentlicht: (2026)

Mispacking of the F87 sidechain drives aggregation‐promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer
von: Xun Sun, et al.
Veröffentlicht: (2024)

Impact of local unfolding fluctuations on the evolution of regional sequence preferences in proteins
von: Keila Voortman‐Sheetz, et al.
Veröffentlicht: (2025)

Mass balance approximation of unfolding boosts potential‐based protein stability predictions
von: Ivan Rossi, et al.
Veröffentlicht: (2025)

Unveiling the unfolded proteome: Evaluation and comparison of methods for the enrichment of intrinsically disordered proteins
von: Luca Secco, et al.
Veröffentlicht: (2026)

Correction to “Chemically induced partial unfolding of the multifunctional apurinic/apyrimidinic endonuclease 1”
Veröffentlicht: (2025)

Mapping the energy landscape of a fold‐switching protein MAD2
von: Ander F. Pereira, et al.
Veröffentlicht: (2025)

Investigation into the effect of phenylalanine gating on anaerobic haem breakdown using the energy landscape approach
von: Alasdair D. Keith, et al.
Veröffentlicht: (2025)

A kinetic gatekeeper: TCR ‐ pMHC dissociation dynamics determine T cell activation efficacy
von: Mingchen Yan, et al.
Veröffentlicht: (2025)

Design of AsLOV2 domain as a carrier of light‐induced dissociable FMN photosensitizer
von: Kristína Felčíková, et al.
Veröffentlicht: (2024)

Tertiary and quaternary structure remodeling by occupancy of the substrate binding pocket in a large glutamate dehydrogenase
von: Melisa Lázaro, et al.
Veröffentlicht: (2026)

Exploring the sequence and structural determinants of the energy landscape from thermodynamically stable and kinetically trapped subtilisins: ISP1 and SbtE
von: Miriam R. Hood, et al.
Veröffentlicht: (2025)

Expanding the therapeutic landscape of PDE10A inhibition through alchemical absolute binding free energy calculations and in‐vitro evaluation
von: Bhanu Sharma, et al.
Veröffentlicht: (2026)

Functional reconstitution of bacterial ESCRT‐III protein PspA identifies key regions in membrane binding and remodeling
von: Samuel Herianto, et al.
Veröffentlicht: (2025)

Exploring binding and allosteric energy landscapes for the KRAS interactions with effector proteins using Markov state modeling of conformational ensembles and allosteric network modeling
von: Sian Xiao, et al.
Veröffentlicht: (2025)

Experimental and computational analysis of the basis for accelerated amyloid formation by a disease linked mutant of human islet amyloid polypeptide
von: Lakshan Manathunga, et al.
Veröffentlicht: (2025)

Lysine Acetylation of Plant α‐Tubulins: Scaling Up the Local Effect to Large System Transformations
von: Alexey Rayevsky, et al.
Veröffentlicht: (2025)

Expanding the biocatalytic and oxidative landscape of the old yellow enzyme family
von: David W. White, et al.
Veröffentlicht: (2025)

The structural landscape of the immunoglobulin fold by large‐scale de novo design
von: Jorge Roel‐Touris, et al.
Veröffentlicht: (2024)

Heterogeneous folding landscapes and predetermined breaking points within a protein family
von: Sebastian Pechmann
Veröffentlicht: (2024)

Correction to “The structural landscape of the immunoglobulin fold by large‐scale de novo design”
Veröffentlicht: (2025)

Concentration‐dependent mutational scanning probes the cellular folding landscape of α‐synuclein in yeast
von: Daeun Noh, et al.
Veröffentlicht: (2026)

Elaboration of the Homer1 recognition landscape reveals incomplete divergence of paralogous EVH1 domains
von: Avinoam Singer, et al.
Veröffentlicht: (2024)

Engineering a bright near‐infrared fluorescent protein by screening a comprehensive phenotypic landscape
von: Devon L. Kulhanek, et al.
Veröffentlicht: (2026)

An in silico framework to visualize how cancer‐associated mutations influence structural plasticity of the chemokine receptor CCR3
von: Evan J. van Aalst, et al.
Veröffentlicht: (2024)

Understanding the stability landscape of LbCas12a by deep analysis of stabilizing mutations and mutation combinations
von: Jiajun Dong, et al.
Veröffentlicht: (2025)

The PERK-eIF2α pathway of the unfolded protein response inhibits white spot syndrome virus infection by attenuating global protein translation.
von: Cui, Chuang, et al.
Veröffentlicht: (2025)

Cleaved versus Uncleaved: How furin cleavage reshapes the conformational landscape of SARS ‐ CoV ‐2 spike
von: Natesan Mani, et al.
Veröffentlicht: (2025)

Biophysical insights into the dimer formation of human Sirtuin 2
von: Noa Suzuki, et al.
Veröffentlicht: (2024)

Diseño de un medio de cultivo sintético para la obtención de una proteína con actividad antitumoral a partir de una bacteria marina
von: Núñez, R.R., et al.
Veröffentlicht: (2002)

NumSimEX: A method using EXX hydrogen exchange mass spectrometry to map the energetics of protein folding landscapes
von: Jasper A. G. Flint, et al.
Veröffentlicht: (2025)

Identifying and quantifying membrane interactions of the protein human cis ‐prenyltransferase
von: Duncan M. Boren, et al.
Veröffentlicht: (2025)

Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7
von: Nurgül Bilgin, et al.
Veröffentlicht: (2024)

Beyond olfaction: New insights into human odorant binding proteins
von: Mifen Chen, et al.
Veröffentlicht: (2026)

Revisiting the structure of UBR box from human UBR6
von: Bokyung Kim, et al.
Veröffentlicht: (2025)

Unveiling nuclear localization signals in human arginine deiminase proteins
von: José L. Neira, et al.
Veröffentlicht: (2026)

MICOS and MIMAS , multifunctional assemblies linking mitochondrial biogenesis, architecture, and function
von: Patrick Horten, et al.
Veröffentlicht: (2026)

Complete combinatorial mutational enumeration of a protein functional site enables sequence‐landscape mapping and identifies highly‐mutated variants that retain activity
von: Mireia Solà Colom, et al.
Veröffentlicht: (2024)