Buchumschlag

FASTIA: A rapid and accessible platform for protein variant interaction analysis demonstrated with a single‐domain antibody

Fuente: Wiley Open Access

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Ryo Matsunaga, Kouhei Tsumoto
Format:	Artículo Open Access
Veröffentlicht:	Wiley 2025
Schlagworte:	Protein Science
Online-Zugang:	Acceder al recurso
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge

High‐throughput system for the thermostability analysis of proteins
von: Sae Ito, et al.
Veröffentlicht: (2024)

Improving the solubility of single domain antibodies using VH‐like hallmark residues
von: Yuta Uto, et al.
Veröffentlicht: (2025)

MemPPI platform for measuring and engineering membrane protein–protein interactions in mammalian cells via split nanoluciferase
von: Weiyi Tang, et al.
Veröffentlicht: (2026)

Loss‐of‐function coding variants in the Ras of complex proteins/ GTPase domain of leucine rich repeat kinase 2
von: Sarah Butterfield, et al.
Veröffentlicht: (2025)

Enzymatic, structural, and biophysical characterization of a single‐domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties
von: Paola Redeghieri, et al.
Veröffentlicht: (2024)

Comparative analysis of the extent of protein–protein interactions in icosahedral viral capsids
von: Noah J. Zimmerman, et al.
Veröffentlicht: (2025)

Glycopolymers stabilize protein folding and protein–protein interactions via enthalpic interactions
von: Sabrina M. Richter, et al.
Veröffentlicht: (2025)

Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains
von: Sherry Wong, et al.
Veröffentlicht: (2024)

Universal paratope–epitope interaction patterns in antibody–antigen structures
von: Marta A. S. Perez, et al.
Veröffentlicht: (2025)

A functional helix shuffled variant of the B domain of Staphylococcus aureus
von: Hanna Bobolowski, et al.
Veröffentlicht: (2025)

MAVISp : A modular structure‐based framework for protein variant effects
von: Matteo Arnaudi, et al.
Veröffentlicht: (2026)

Structures of a synthetic antibody selected against and bound to the C‐terminal domain of Clostridium perfringens enterotoxin
von: Chinemerem P. Ogbu, et al.
Veröffentlicht: (2025)

Thermostability and binding properties of single‐chained Fv fragments derived from therapeutic antibodies
von: Takashi Tadokoro, et al.
Veröffentlicht: (2024)

A significance score for protein–protein interaction models through random docking
von: Katherine Maia McCoy, et al.
Veröffentlicht: (2024)

Family‐level specialization in protein domain insertion architectures
von: R. Dustin Schaeffer, et al.
Veröffentlicht: (2026)

Heat‐sterilizable antibody mimics designed on the cold shock protein scaffold from hyperthermophile Thermotoga maritima
von: Hiroshi Amesaka, et al.
Veröffentlicht: (2024)

Allosteric regulation of the tyrosine phosphatase PTP1B by a protein–protein interaction
von: Cassandra A. Chartier, et al.
Veröffentlicht: (2024)

MAGPIE: An interactive tool for visualizing and analyzing protein–ligand interactions
von: Daniel C. Pineda Rodriguez, et al.
Veröffentlicht: (2024)

Supervised learning of protein variant effects across large‐scale mutagenesis datasets
von: Thea K. Schulze, et al.
Veröffentlicht: (2026)

Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII .4 and GII .17
von: Jumpei Tagawa, et al.
Veröffentlicht: (2026)

HAIRpred : Prediction of human antibody interacting residues in an antigen from its primary structure
von: Ruchir Sahni, et al.
Veröffentlicht: (2025)

Cell surface β‐lactamase recruitment: A facile selection to identify protein–protein interactions
von: Jordan A. Hinmon, et al.
Veröffentlicht: (2024)

Design and evolution of a synthetic small protein scaffold based on the WW domain
von: Ana Margarida Gonçalves Carvalho Dias, et al.
Veröffentlicht: (2025)

Inhibitory protein–protein interactions of the SIRT1 deacetylase are choreographed by post‐translational modification
von: Troy C. Krzysiak, et al.
Veröffentlicht: (2024)

19F NMR‐based solvent accessibility profiling reveals tryptophan ring‐flip dynamics in a protein
von: Soichiro Kawagoe, et al.
Veröffentlicht: (2025)

Proline variants in the BRCA1 coiled‐coil domain disrupt folding and binding to PALB2
von: Chrissy N. S. Baker, et al.
Veröffentlicht: (2024)

Fine‐tuned interactions between globular and disordered regions of single‐stranded DNA binding (SSB) protein are required for dynamic condensation under physiological conditions
von: Zoltán J. Kovács, et al.
Veröffentlicht: (2025)

Calpain– MMP 3 activation restricts nuclear uptake during protein transduction domain TAT ‐mediated protein delivery
von: Jin Hyeop Kim, et al.
Veröffentlicht: (2026)

Targeting the apical domain of the transferrin receptor: Development of a new protein scaffold for cellular delivery
von: Anuthariq Alikkam Veetil, et al.
Veröffentlicht: (2025)

Toward physics‐based precision medicine: Exploiting protein dynamics to design new therapeutics and interpret variants
von: Artur Meller, et al.
Veröffentlicht: (2024)

Comparison of enriched charge variants from different anti‐CD3 bispecific antibodies reveals differential susceptibility of each bispecific arm to post‐translational modification
von: Jennifer B. Nguyen, et al.
Veröffentlicht: (2025)

Identifying and quantifying membrane interactions of the protein human cis ‐prenyltransferase
von: Duncan M. Boren, et al.
Veröffentlicht: (2025)

Energy, water, and protein folding: A molecular dynamics‐based quantitative inventory of molecular interactions and forces that make proteins stable
von: Juan José Galano‐Frutos, et al.
Veröffentlicht: (2024)

Ligation of multiple protein domains using orthogonal inteins with non‐native splice junctions
von: Alejandro Romero‐Casañas, et al.
Veröffentlicht: (2024)

Chemical and temporal manipulation of early steps in protein assembly tunes the structure and intermolecular interactions of protein‐based materials
von: Valeria Italia, et al.
Veröffentlicht: (2025)

Key interaction networks: Identifying evolutionarily conserved non‐covalent interaction networks across protein families
von: Dariia Yehorova, et al.
Veröffentlicht: (2024)

A single buried cysteine acts as a hydrophobic stabilizer of a folding intermediate and transition state in the MATH domain of SPOP
von: Livia Pagano, et al.
Veröffentlicht: (2025)

Complete combinatorial mutational enumeration of a protein functional site enables sequence‐landscape mapping and identifies highly‐mutated variants that retain activity
von: Mireia Solà Colom, et al.
Veröffentlicht: (2024)

Hierarchy in regulator interactions with distant transcriptional activation domains empowers rheostatic regulation
von: Amanda D. Due, et al.
Veröffentlicht: (2025)

Structural and functional characterization of a hyperthermostable single‐stranded DNA ‐binding protein from a hot spring metagenome
von: Olesia Werbowy, et al.
Veröffentlicht: (2026)