Buchumschlag

The role of phospholipid saturation and composition in α‐synuclein aggregation and toxicity: A dual in vitro and in vivo approach

Fuente: Wiley Open Access

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Aidan P. Holman, Tianyi Dou, Mikhail Matveyenka, Kiryl Zhaliazka, Anjni Patel, Avery Maalouf, Ragd Elsaigh, Dmitry Kurouski
Format:	Artículo Open Access
Veröffentlicht:	Wiley 2025
Schlagworte:	Protein Science
Online-Zugang:	Acceder al recurso
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge

Tubulin‐binding region alters tau–lipid interactions and changes toxicity of tau fibrils formed in the presence of phosphatidylserine lipids
von: Abid Ali, et al.
Veröffentlicht: (2024)

Biophysical assessment of the molecular mechanisms of Tau aggregation and its role in Alzheimer's disease
von: Joshua T. Skrehot, et al.
Veröffentlicht: (2026)

Indirect Detection of Swine Influenza Activity in Porcine Blood Using Raman Spectroscopy and Machine Learning
von: Aidan Paul Holman, et al.
Veröffentlicht: (2025)

Competing chaperone pathways in α‐synuclein disaggregation and aggregation dynamics
von: Nicola K. Auld, et al.
Veröffentlicht: (2025)

Specific inhibition of α‐synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS
von: Laurène Adam, et al.
Veröffentlicht: (2024)

Structural and morphological dynamics of “on‐path” and “off‐path” oligomers of human islet amyloid polypeptide
von: Daniel Warren, et al.
Veröffentlicht: (2026)

Copper ion incorporation in α‐synuclein amyloids
von: Gulshan Walke, et al.
Veröffentlicht: (2024)

Amyloid formation of alternatively spliced variants of α‐synuclein
von: Daniel Q. SanGiovanni, et al.
Veröffentlicht: (2025)

In vitro, cellular and in vivo studies of amyloid oligomers structure and toxicity: Challenges and advances
von: Magdalena I. Ivanova, et al.
Veröffentlicht: (2026)

Structural insights into the unique recognition module between α‐synuclein peptide and nanobody
von: Zeyaul Islam, et al.
Veröffentlicht: (2024)

The effects of biological crowders on fibrillization, structure, diffusion, and conformational dynamics of α‐synuclein
von: Sina Heravi, et al.
Veröffentlicht: (2024)

Concentration‐dependent mutational scanning probes the cellular folding landscape of α‐synuclein in yeast
von: Daeun Noh, et al.
Veröffentlicht: (2026)

Multivalent interaction induces phase separation and formation of more toxic aggregates of α‐syn in a yeast model of Parkinson's disease
von: Rajeev Jain, et al.
Veröffentlicht: (2025)

The intrinsically disordered protein NUPR1 binds to phospholipids
von: Matías Estaras, et al.
Veröffentlicht: (2025)

In silico peptide self‐assembly reveals the importance of N‐terminal motifs and the inhibition mechanism of the mutation L38M in α ‐synuclein fibrillation
von: Van T. T. Nguyen, et al.
Veröffentlicht: (2026)

An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo
von: Jarrett J. Adams, et al.
Veröffentlicht: (2025)

Critical micellar concentration determination of pure phospholipids and lipid‐raft and their mixtures with cholesterol
von: Sofia Serravalle, et al.
Veröffentlicht: (2024)

An intein‐based biosensor to measure protein stability in vivo
von: Ahyun Son, et al.
Veröffentlicht: (2024)

Guide to the structural characterization of protein aggregates and amyloid fibrils by CD spectroscopy
von: József Kardos, et al.
Veröffentlicht: (2025)

Inhibition of tau aggregation by the CCT3 and CCT7 apical domains
von: Miki Ben‐Maimon, et al.
Veröffentlicht: (2025)

Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains
von: Sherry Wong, et al.
Veröffentlicht: (2024)

Tetravalent antibodies are more potent and efficacious erythropoiesis‐stimulating agents than erythropoietin in vivo
von: Jarrett J. Adams, et al.
Veröffentlicht: (2026)

AggNet: Advancing protein aggregation analysis through deep learning and protein language model
von: Wenjia He, et al.
Veröffentlicht: (2025)

DNA recognition, cleavage, and toxic metal ion interaction of an artificial zinc finger protein inside E. coli cells
von: Bálint Hajdu, et al.
Veröffentlicht: (2026)

Mispacking of the F87 sidechain drives aggregation‐promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer
von: Xun Sun, et al.
Veröffentlicht: (2024)

Aggrescan4D: A comprehensive tool for pH‐dependent analysis and engineering of protein aggregation propensity
von: Mateusz Zalewski, et al.
Veröffentlicht: (2024)

The dual‐coding gene SLC35A4 protects against oxidative stress
von: Ikram Ajala, et al.
Veröffentlicht: (2025)

One‐pot dual protein labeling for simultaneous mechanical and fluorescent readouts in optical tweezers
von: Laura‐Marie Silbermann, et al.
Veröffentlicht: (2025)

Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors
von: Giulia Cazzanelli, et al.
Veröffentlicht: (2024)

Tubulin‐Binding Region Modulates Cholesterol‐Triggered Aggregation of Tau Proteins
von: Abid Ali, et al.
Veröffentlicht: (2025)

An in vitro set‐up to study Pdr5‐mediated substrate translocation
von: Stefanie L. Gala Marti, et al.
Veröffentlicht: (2024)

Diseño de un medio de cultivo sintético para la obtención de una proteína con actividad antitumoral a partir de una bacteria marina
von: Núñez, R.R., et al.
Veröffentlicht: (2002)

α‐N‐Methyltransferase regiospecificity is mediated by proximal, redundant enzyme–substrate interactions
von: Kathryn K. Crone, et al.
Veröffentlicht: (2025)

A sequence‐based model for identifying proteins undergoing liquid–liquid phase separation/forming fibril aggregates via machine learning
von: Shaofeng Liao, et al.
Veröffentlicht: (2024)

Single‐molecule force spectroscopy discovers a dual‐binding mode in the hCG ‐mediated activation of LHCGR
von: Qian Han, et al.
Veröffentlicht: (2026)

Growth hormone receptor antagonists, GHA2 and GHA3, with dual activity against the human and mouse receptor
von: Yue Wang, et al.
Veröffentlicht: (2025)

Surface‐modified protein crowders influence mutant huntingtin exon 1 aggregation via crowding effects, crowder association, and crowder solution stability
von: Jakub Haduła, et al.
Veröffentlicht: (2025)

Localized Amino Acid Enrichment Analysis as a Tool for Understanding Protein Extremophilicity
von: Elliot Hill, et al.
Veröffentlicht: (2024)

Ultrasonication‐induced in vitro formation of transthyretin mature amyloid fibrils at neutral pH
von: Keisuke Yuzu, et al.
Veröffentlicht: (2026)

Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP ‐43 low‐complexity domain
von: Thomas B. Walker, et al.
Veröffentlicht: (2026)