Buchumschlag

Loss‐of‐function coding variants in the Ras of complex proteins/ GTPase domain of leucine rich repeat kinase 2

Fuente: Wiley Open Access

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Sarah Butterfield, Susanne Herbst, Patrick Alfryn Lewis
Format:	Artículo Open Access
Veröffentlicht:	Wiley 2025
Schlagworte:	Protein Science
Online-Zugang:	Acceder al recurso
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge

Membrane‐dependent assembly of Bruton's tyrosine kinase mediated by the Proline‐rich region and SH3 domain
von: Alexander D. Fenton, et al.
Veröffentlicht: (2025)

Use of tandem‐affinity chromatography to incorporate nucleotide loading of small GTPases during their purification
von: Rofiat Oladimeji, et al.
Veröffentlicht: (2026)

Classifying protein kinase conformations with machine learning
von: Ivan Reveguk, et al.
Veröffentlicht: (2024)

A functional helix shuffled variant of the B domain of Staphylococcus aureus
von: Hanna Bobolowski, et al.
Veröffentlicht: (2025)

FASTIA: A rapid and accessible platform for protein variant interaction analysis demonstrated with a single‐domain antibody
von: Ryo Matsunaga, et al.
Veröffentlicht: (2025)

Lysine acetylation modulates s‐OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling
von: Javaid Jabbar, et al.
Veröffentlicht: (2025)

Computational model predicts function of Rho‐GTPase binding for plexin receptor GAP activity on Rap1b via dynamic allosteric changes
von: Nisha Bhattarai, et al.
Veröffentlicht: (2025)

pLM ‐Repeat: Exploiting the sequence representations of protein language models for sensitive repeat detection
von: Kaiyu Qiu, et al.
Veröffentlicht: (2026)

Structural characterization of the Sel1‐like repeat protein LceB from Legionella pneumophila
von: Tiffany V. Penner, et al.
Veröffentlicht: (2024)

Assessing the mechanism of fast‐cycling cancer‐associated mutations of Rac1 small Rho GTPase
von: Angela Parise, et al.
Veröffentlicht: (2024)

Proline variants in the BRCA1 coiled‐coil domain disrupt folding and binding to PALB2
von: Chrissy N. S. Baker, et al.
Veröffentlicht: (2024)

Ligand‐induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity
von: Dilip Narayanan, et al.
Veröffentlicht: (2024)

MAVISp : A modular structure‐based framework for protein variant effects
von: Matteo Arnaudi, et al.
Veröffentlicht: (2026)

Family‐level specialization in protein domain insertion architectures
von: R. Dustin Schaeffer, et al.
Veröffentlicht: (2026)

Restoring adapter protein complex 4 function with small molecules: an in silico approach to spastic paraplegia 50
von: Serena Francisco, et al.
Veröffentlicht: (2024)

Supervised learning of protein variant effects across large‐scale mutagenesis datasets
von: Thea K. Schulze, et al.
Veröffentlicht: (2026)

Complete combinatorial mutational enumeration of a protein functional site enables sequence‐landscape mapping and identifies highly‐mutated variants that retain activity
von: Mireia Solà Colom, et al.
Veröffentlicht: (2024)

Molecular basis of the CYFIP2 and NCKAP1 autism‐linked variants in the WAVE regulatory complex
von: Song Xie, et al.
Veröffentlicht: (2024)

A look beyond the QR code of SNARE proteins
von: Deepak Yadav, et al.
Veröffentlicht: (2024)

Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP ‐43 low‐complexity domain
von: Thomas B. Walker, et al.
Veröffentlicht: (2026)

The peptidyl‐prolyl cis‐trans isomerase, Pin1, is a regulator of the protein kinase C θ ( PKCθ ) catalytic activity in activated T cells
von: Nikhil Ponnoor Anto, et al.
Veröffentlicht: (2025)

Calpain– MMP 3 activation restricts nuclear uptake during protein transduction domain TAT ‐mediated protein delivery
von: Jin Hyeop Kim, et al.
Veröffentlicht: (2026)

Design and evolution of a synthetic small protein scaffold based on the WW domain
von: Ana Margarida Gonçalves Carvalho Dias, et al.
Veröffentlicht: (2025)

Toward physics‐based precision medicine: Exploiting protein dynamics to design new therapeutics and interpret variants
von: Artur Meller, et al.
Veröffentlicht: (2024)

Assessing scoring metrics for AlphaFold2 and AlphaFold3 protein complex predictions
von: Luca R. Genz, et al.
Veröffentlicht: (2025)

The soluble state of the HIV ‐1 Vpu protein forms a complex with Ca 2+ ‐calmodulin
von: Olamide Ishola, et al.
Veröffentlicht: (2026)

Ligation of multiple protein domains using orthogonal inteins with non‐native splice junctions
von: Alejandro Romero‐Casañas, et al.
Veröffentlicht: (2024)

PackPPI: An integrated framework for protein–protein complex side‐chain packing and ΔΔG prediction based on diffusion model
von: Jingkai Zhang, et al.
Veröffentlicht: (2025)

Phosphorylation of a conserved aspartate in the catalytic site of eukaryotic elongation factor 2 kinase
von: Andrea Piserchio, et al.
Veröffentlicht: (2025)

Targeting the apical domain of the transferrin receptor: Development of a new protein scaffold for cellular delivery
von: Anuthariq Alikkam Veetil, et al.
Veröffentlicht: (2025)

Destabilization of the D2 domain of Thermotoga maritima arginine binding protein induced by guanidinium thiocyanate and its counteraction by stabilizing agents
von: Guido Izzi, et al.
Veröffentlicht: (2024)

Unlocking complexity through neutron scattering: Structure and dynamics of protein–polymer conjugates
von: Daniela Russo, et al.
Veröffentlicht: (2025)

Assessing the functional impact of protein binding site definition
von: Prithviraj Nandigrami, et al.
Veröffentlicht: (2024)

Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes
von: Andrew K. Maytin, et al.
Veröffentlicht: (2026)

The BRAF ‐specific region suppresses cysteine‐rich domain–lipid interaction independently of canonical autoinhibition by the 14‐3‐3 dimer
von: Vasili Revazishvili, et al.
Veröffentlicht: (2025)

Genetic mutations disrupt the coordinated mode of tyrosinase's intra‐melanosomal domain
von: Sarah Toay, et al.
Veröffentlicht: (2025)

Clustering protein functional families at large scale with hierarchical approaches
von: Nicola Bordin, et al.
Veröffentlicht: (2024)

PDB ‐ CAT : A user‐friendly tool to classify and analyze PDB protein–ligand complexes
von: Ariadna Llop‐Peiró, et al.
Veröffentlicht: (2025)

Structural studies of intrinsically disordered MLL‐fusion protein AF9 in complex with peptidomimetic inhibitors
von: Yuting Yang, et al.
Veröffentlicht: (2024)

SHARK‐capture identifies functional motifs in intrinsically disordered protein regions
von: Chi Fung Willis Chow, et al.
Veröffentlicht: (2025)