Cover Image

Amyloid formation of alternatively spliced variants of α‐synuclein

Fuente: Wiley Open Access

Saved in:

Bibliographic Details
Main Authors:	Daniel Q. SanGiovanni, Ryan P. McGlinchey, Jennifer C. Lee
Format:	Artículo Open Access
Published:	Wiley 2025
Subjects:	Protein Science
Online Access:	Acceder al recurso
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Competing chaperone pathways in α‐synuclein disaggregation and aggregation dynamics
by: Nicola K. Auld, et al.
Published: (2025)

Copper ion incorporation in α‐synuclein amyloids
by: Gulshan Walke, et al.
Published: (2024)

Structural insights into the unique recognition module between α‐synuclein peptide and nanobody
by: Zeyaul Islam, et al.
Published: (2024)

The effects of biological crowders on fibrillization, structure, diffusion, and conformational dynamics of α‐synuclein
by: Sina Heravi, et al.
Published: (2024)

Specific inhibition of α‐synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS
by: Laurène Adam, et al.
Published: (2024)

Concentration‐dependent mutational scanning probes the cellular folding landscape of α‐synuclein in yeast
by: Daeun Noh, et al.
Published: (2026)

The role of phospholipid saturation and composition in α‐synuclein aggregation and toxicity: A dual in vitro and in vivo approach
by: Aidan P. Holman, et al.
Published: (2025)

In silico peptide self‐assembly reveals the importance of N‐terminal motifs and the inhibition mechanism of the mutation L38M in α ‐synuclein fibrillation
by: Van T. T. Nguyen, et al.
Published: (2026)

An ALS ‐associated mutation in the C‐terminal α‐helix of TDP ‐43 uncouples condensate formation and amyloid assembly
by: Emily J. Byrd, et al.
Published: (2026)

Ligation of multiple protein domains using orthogonal inteins with non‐native splice junctions
by: Alejandro Romero‐Casañas, et al.
Published: (2024)

Human islet amyloid polypeptide‐induced β‐cell cytotoxicity is linked to formation of α‐sheet structure
by: Cheng‐Chieh Hsu, et al.
Published: (2024)

Multivalent interaction induces phase separation and formation of more toxic aggregates of α‐syn in a yeast model of Parkinson's disease
by: Rajeev Jain, et al.
Published: (2025)

Translation of the downstream ORF from bicistronic mRNAs by human cells: Impact of codon usage and splicing in the upstream ORF
by: Philippe Paget‐Bailly, et al.
Published: (2025)

Experimental and computational analysis of the basis for accelerated amyloid formation by a disease linked mutant of human islet amyloid polypeptide
by: Lakshan Manathunga, et al.
Published: (2025)

Conformational state of myosin's disordered loop 2 structure mediates actomyosin association during crossbridge formation
by: Kalen Z. Robeson, et al.
Published: (2026)

Proline variants in the BRCA1 coiled‐coil domain disrupt folding and binding to PALB2
by: Chrissy N. S. Baker, et al.
Published: (2024)

A functional helix shuffled variant of the B domain of Staphylococcus aureus
by: Hanna Bobolowski, et al.
Published: (2025)

MAVISp : A modular structure‐based framework for protein variant effects
by: Matteo Arnaudi, et al.
Published: (2026)

ConforFold recovers alternative protein conformations beyond MSA subsampling
by: Raulia Syrlybaeva, et al.
Published: (2026)

Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII .4 and GII .17
by: Jumpei Tagawa, et al.
Published: (2026)

Design and characterization of calprotectin tetramerization variants for probing the role of oligomerization in receptor activation
by: Velia Garcia, et al.
Published: (2025)

Supervised learning of protein variant effects across large‐scale mutagenesis datasets
by: Thea K. Schulze, et al.
Published: (2026)

Comparison of enriched charge variants from different anti‐CD3 bispecific antibodies reveals differential susceptibility of each bispecific arm to post‐translational modification
by: Jennifer B. Nguyen, et al.
Published: (2025)

An improved variant of tobacco etch virus (TEV) protease that does not need reducing agents
by: Stella M. Davis, et al.
Published: (2025)

Discovery of a novel homocysteine thiolactone hydrolase and the catalytic activity of its natural variants
by: Shurong Hou, et al.
Published: (2024)

Structure‐based development of a canine TNF‐α‐specific antibody using adalimumab as a template
by: Cheng‐Chung Lee, et al.
Published: (2024)

Cellular turnover and degradation of the most common missense cystathionine beta‐synthase variants causing homocystinuria
by: Ela Mijatovic, et al.
Published: (2024)

Molecular basis of the CYFIP2 and NCKAP1 autism‐linked variants in the WAVE regulatory complex
by: Song Xie, et al.
Published: (2024)

Computational and experimental identification of keystone interactions in Ebola virus matrix protein VP40 dimer formation
by: Yogesh Narkhede, et al.
Published: (2024)

Toward physics‐based precision medicine: Exploiting protein dynamics to design new therapeutics and interpret variants
by: Artur Meller, et al.
Published: (2024)

Biophysical insights into the dimer formation of human Sirtuin 2
by: Noa Suzuki, et al.
Published: (2024)

An alternative pocket for binding the N‐degrons by the UBR1 and UBR2 ubiquitin E3 ligases
by: Shih‐Ting Huang, et al.
Published: (2025)

Hydrophobic interactions of a substrate with L193 on the flexible substrate‐binding loop contribute to 3α‐hydroxysteroid dehydrogenase/carbonyl reductase catalytic efficiency
by: Yan‐Liang Chen, et al.
Published: (2026)

A splice-site variant in the () gene identified in a symptomatic carrier woman.
by: Domoto, Aya, et al.
Published: (2026)

FASTIA: A rapid and accessible platform for protein variant interaction analysis demonstrated with a single‐domain antibody
by: Ryo Matsunaga, et al.
Published: (2025)

Loss‐of‐function coding variants in the Ras of complex proteins/ GTPase domain of leucine rich repeat kinase 2
by: Sarah Butterfield, et al.
Published: (2025)

α‐N‐Methyltransferase regiospecificity is mediated by proximal, redundant enzyme–substrate interactions
by: Kathryn K. Crone, et al.
Published: (2025)

AlphaFold modeling uncovers global structural features of class I and class II fungal hydrophobins
by: Li‐Yen Yang, et al.
Published: (2025)

Complete combinatorial mutational enumeration of a protein functional site enables sequence‐landscape mapping and identifies highly‐mutated variants that retain activity
by: Mireia Solà Colom, et al.
Published: (2024)

Ultrasonication‐induced in vitro formation of transthyretin mature amyloid fibrils at neutral pH
by: Keisuke Yuzu, et al.
Published: (2026)