Cover Image

Tertiary and quaternary structure remodeling by occupancy of the substrate binding pocket in a large glutamate dehydrogenase

Fuente: Wiley Open Access

Saved in:

Bibliographic Details
Main Authors:	Melisa Lázaro, Nicolás Chamorro, Jorge P. López‐Alonso, Diego Charro, Rodolfo M. Rasia, Gonzalo Jiménez‐Osés, Mikel Valle, María‐Natalia Lisa
Format:	Artículo Open Access
Published:	Wiley 2026
Subjects:	Protein Science
Online Access:	Acceder al recurso
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The role of the flexible loop region in the substrate binding and catalytic activity of malate dehydrogenases
by: Varuni K. Jamburuthugoda, et al.
Published: (2025)

Conformational flexibility associated with remote residues regulates the kinetic properties of glutamate dehydrogenase
by: Barsa Kanchan Jyotshna Godsora, et al.
Published: (2025)

Hydrophobic interactions of a substrate with L193 on the flexible substrate‐binding loop contribute to 3α‐hydroxysteroid dehydrogenase/carbonyl reductase catalytic efficiency
by: Yan‐Liang Chen, et al.
Published: (2026)

Buttressing ligand‐binding pockets in de novo designed NTF2 ‐like domains
by: Marta Nadal, et al.
Published: (2025)

An alternative pocket for binding the N‐degrons by the UBR1 and UBR2 ubiquitin E3 ligases
by: Shih‐Ting Huang, et al.
Published: (2025)

Functional reconstitution of bacterial ESCRT‐III protein PspA identifies key regions in membrane binding and remodeling
by: Samuel Herianto, et al.
Published: (2025)

Molecular basis for different substrate‐binding sites and chaperone functions of the BRICHOS domain
by: Gefei Chen, et al.
Published: (2024)

Structural insight into the substrate binding of the AMT complex via an inhibitor‐trapped state
by: Zengyu Shao, et al.
Published: (2025)

An intrinsically disordered region of Ubp10 regulates its binding and activity on ubiquitinated histone substrates
by: Anneliese M. Faustino, et al.
Published: (2025)

How arginine inhibits substrate‐binding domain 2 elucidated using molecular dynamics simulations
by: Maximilian Kienlein, et al.
Published: (2024)

Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket
by: Jyoti Verma, et al.
Published: (2026)

Allosteric regulation of L‐lactate dehydrogenase: Beyond effector‐mediated tetramerization
by: Hanfeng Cai, et al.
Published: (2025)

The mineralocorticoid receptor forms higher order oligomers upon DNA binding
by: Gregory Fettweis, et al.
Published: (2024)

Helicobacter pylori FlgN binds its substrate FlgK and the flagellum ATPase FliI in a similar manner observed for the FliT chaperone
by: Poonam Dhindwal, et al.
Published: (2024)

Post‐translational regulation of human D‐3‐phosphoglycerate dehydrogenase in Alzheimer's disease
by: Elena Zerbini, et al.
Published: (2026)

Not only an inhibitor: Trehalose enhances the catalytic action exerted on oxaloacetate by rabbit lactate dehydrogenase
by: Alessandra Stefan, et al.
Published: (2025)

Discovery of periplasmic solute binding proteins with specificity for ketone bodies: β‐hydroxybutyrate binding proteins
by: Bryant J. Kane, et al.
Published: (2024)

Lysine acetylation modulates s‐OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling
by: Javaid Jabbar, et al.
Published: (2025)

Structural dynamics and binding of Caenorhabditis elegans lifespan‐extending lipid binding protein‐3 to polyunsaturated fatty acids
by: André R. Cuevas, et al.
Published: (2024)

Engineering diaryl alcohol dehydrogenase KpADH reveals importance of retaining hydration shell in organic solvent tolerance
by: Lu Zhang, et al.
Published: (2024)

The structural basis for the broad aldehyde specificity of the aminoaldehyde dehydrogenase PauC from the human pathogen Pseudomonas aeruginosa
by: Yudy V. Cardona‐Cardona, et al.
Published: (2025)

Evidence for vitellogenin DNA‐binding in honey bees
by: Gyan Harwood, et al.
Published: (2025)

Structural basis for no retinal binding in flotillin-associated rhodopsins.
by: Kovalev, Kirill, et al.
Published: (2025)

Complexity associated with caprylate binding to bovine serum albumin: Dimerization, allostery, and variance between the change in free energy and enthalpy of binding
by: Marc Joseph A. Capili, et al.
Published: (2024)

Lysine carbamoylation during urea denaturation remodels the energy landscape of human transthyretin dissociation linked to unfolding
by: Marcus Jäger, et al.
Published: (2025)

Peptides inhibiting the assembly of monomeric human l‐lactate dehydrogenase into catalytically active homotetramer decrease the synthesis of lactate in cultured cells
by: Alessandra Stefan, et al.
Published: (2024)

Crustacean methyl farnesoate-binding protein is an insect juvenile hormone-binding protein homolog that inhibits molting.
by: Yang, Hao, et al.
Published: (2025)

A la carte bioprospecting of substrate‐selective laccases via high‐throughput computational enzyme–substrate interaction profiling
by: Ruite Xiang, et al.
Published: (2026)

The intrinsically disordered protein NUPR1 binds to phospholipids
by: Matías Estaras, et al.
Published: (2025)

Assessing the functional impact of protein binding site definition
by: Prithviraj Nandigrami, et al.
Published: (2024)

Molecular mechanism of Fe3+ binding inhibition to Vibrio metschnikovii ferric ion‐binding protein, FbpA, by rosmarinic acid and its hydrolysate, danshensu
by: Peng Lu, et al.
Published: (2024)

Predicting interacting hotspots for nanobodies' binding using triplets of residues
by: Rahma Hamdani, et al.
Published: (2025)

Beyond olfaction: New insights into human odorant binding proteins
by: Mifen Chen, et al.
Published: (2026)

Mechanism of (−)‐Englerin A and calcium binding on the human TRPC5 channel
by: Yikun Chen, et al.
Published: (2025)

Functional thermodynamics govern the ligand binding to human cytosolic transport proteins
by: Sebastian Michler, et al.
Published: (2026)

Reengineering of a flavin‐binding fluorescent protein using ProteinMPNN
by: Andrey Nikolaev, et al.
Published: (2024)

Diversity of FAAL enzymes and prediction of their substrate specificity using FAALPred
by: Anne Liong, et al.
Published: (2026)

Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates
by: Elany B. Silva, et al.
Published: (2025)

Detergents alter the stability and lipid binding properties of the CD1d immunoreceptor
by: Uri Z. Miles, et al.
Published: (2025)

Fibrinogen‐binding M‐related proteins facilitate the recruitment of plasminogen by Streptococcus pyogenes
by: Emma‐Jayne Proctor, et al.
Published: (2025)