Isolation and identification of diterpenoids and lignans from the Juniperus sabina L. with insecticidal activities
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| Format: | Artículo Open Access |
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Wiley
2025
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| _version_ | 1867019216397271040 |
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| author | Wei‐Jia Li Hai Li Guang‐Ze Li Rui‐Hong Feng Hai‐Yan Yan Hua Wu Bin Zhang Zhi‐Qing Ma |
| author_facet | Wei‐Jia Li Hai Li Guang‐Ze Li Rui‐Hong Feng Hai‐Yan Yan Hua Wu Bin Zhang Zhi‐Qing Ma Wei‐Jia Li Hai Li Guang‐Ze Li Rui‐Hong Feng Hai‐Yan Yan Hua Wu Bin Zhang Zhi‐Qing Ma |
| collection | Wiley Open Access |
| contents | Isolation and identification of diterpenoids and lignans from the Juniperus sabina L. with insecticidal activities Wei‐Jia Li Hai Li Guang‐Ze Li Rui‐Hong Feng Hai‐Yan Yan Hua Wu Bin Zhang Zhi‐Qing Ma Pest Management Science Abstract BACKGROUND Botanical insecticides have received extensive attention due to their environmental friendliness and biodegradability. The isolation and identification of active compounds are the most innovative and vigorous stages in botanical pesticide development. This study aims to isolate and identify the insecticidal compounds present in Juniperus sabina L., with the goal of establishing a scientific foundation for developing an environmentally friendly and cost‐effective alternative to conventional synthetic pesticides. RESULTS Through bioassay‐guided isolation, 13 active compounds were obtained, all of which demonstrated significant antifeedant activity against third instar larvae of Mythimna separata . Notably, the lignan compounds exhibited potent insecticidal properties and effectively inhibited larval growth and development. Among the compounds, 4′‐demethylpodophyllotoxin ( 12 ) exhibited the most potent antifeedant activity against third instar larvae of M. separata , with a median antifeeding concentration (AFC 50 ) of 64.6 μg/mL. Meanwhile, yatein ( 6 ) demonstrated remarkable insecticidal activity against fourth instar larvae of Pieris rapae (half‐maximal lethal concentration, LC 50 = 293 μg/mL) and third instar larvae of Plutella xylostella (LC 50 = 1.18 mg/mL). Additionally, yatein ( 6 ) displayed significant insect growth regulator effects on M. separata , including an increased abnormal pupation rate, prolonged pupal and larval durations, and a notable reduction in larval weight, pupation rate, emergence rate, egg hatchability, and single female oviposition number. CONCLUSION Our findings offer valuable insights into the discovery of novel insecticidal compounds derived from J. sabina . 4′‐Demethylpodophyllotoxin ( 12 ) and yatein ( 6 ) exhibited significant potential as promising candidates for the development of new botanical pesticides. © 2025 Society of Chemical Industry. 10.1002/ps.70139 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/ps.70139 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ps_70139 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Isolation and identification of diterpenoids and lignans from the Juniperus sabina L. with insecticidal activities Wei‐Jia Li Hai Li Guang‐Ze Li Rui‐Hong Feng Hai‐Yan Yan Hua Wu Bin Zhang Zhi‐Qing Ma Pest Management Science Isolation and identification of diterpenoids and lignans from the Juniperus sabina L. with insecticidal activities Wei‐Jia Li Hai Li Guang‐Ze Li Rui‐Hong Feng Hai‐Yan Yan Hua Wu Bin Zhang Zhi‐Qing Ma Pest Management Science Abstract BACKGROUND Botanical insecticides have received extensive attention due to their environmental friendliness and biodegradability. The isolation and identification of active compounds are the most innovative and vigorous stages in botanical pesticide development. This study aims to isolate and identify the insecticidal compounds present in Juniperus sabina L., with the goal of establishing a scientific foundation for developing an environmentally friendly and cost‐effective alternative to conventional synthetic pesticides. RESULTS Through bioassay‐guided isolation, 13 active compounds were obtained, all of which demonstrated significant antifeedant activity against third instar larvae of Mythimna separata . Notably, the lignan compounds exhibited potent insecticidal properties and effectively inhibited larval growth and development. Among the compounds, 4′‐demethylpodophyllotoxin ( 12 ) exhibited the most potent antifeedant activity against third instar larvae of M. separata , with a median antifeeding concentration (AFC 50 ) of 64.6 μg/mL. Meanwhile, yatein ( 6 ) demonstrated remarkable insecticidal activity against fourth instar larvae of Pieris rapae (half‐maximal lethal concentration, LC 50 = 293 μg/mL) and third instar larvae of Plutella xylostella (LC 50 = 1.18 mg/mL). Additionally, yatein ( 6 ) displayed significant insect growth regulator effects on M. separata , including an increased abnormal pupation rate, prolonged pupal and larval durations, and a notable reduction in larval weight, pupation rate, emergence rate, egg hatchability, and single female oviposition number. CONCLUSION Our findings offer valuable insights into the discovery of novel insecticidal compounds derived from J. sabina . 4′‐Demethylpodophyllotoxin ( 12 ) and yatein ( 6 ) exhibited significant potential as promising candidates for the development of new botanical pesticides. © 2025 Society of Chemical Industry. 10.1002/ps.70139 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Isolation and identification of diterpenoids and lignans from the Juniperus sabina L. with insecticidal activities |
| topic | Pest Management Science |
| url | https://scijournals.onlinelibrary.wiley.com/doi/10.1002/ps.70139 |