Design and synthesis of camphor‐thiazole derivatives as potent antifungal agents: structure–activity relationship and preliminary mechanistic study
Fuente:
Wiley Open Access
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Veröffentlicht: |
Wiley
2024
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1867006492051243008 |
|---|---|
| author | Peng Dai Zihua Ma Yuncong Dang Jiaxuan Huang Huizhen Xue Yafang Sun Yu‐Cheng Gu Qing Xia Weihua Zhang |
| author_facet | Peng Dai Zihua Ma Yuncong Dang Jiaxuan Huang Huizhen Xue Yafang Sun Yu‐Cheng Gu Qing Xia Weihua Zhang Peng Dai Zihua Ma Yuncong Dang Jiaxuan Huang Huizhen Xue Yafang Sun Yu‐Cheng Gu Qing Xia Weihua Zhang |
| collection | Wiley Open Access |
| contents | Design and synthesis of camphor‐thiazole derivatives as potent antifungal agents: structure–activity relationship and preliminary mechanistic study Peng Dai Zihua Ma Yuncong Dang Jiaxuan Huang Huizhen Xue Yafang Sun Yu‐Cheng Gu Qing Xia Weihua Zhang Pest Management Science AbstractBACKGROUNDPlant pathogenic fungi pose a severe threat to crop yield and food security. This study aims to investigate the potential antifungal activity and mechanism of action of camphor‐thiazole derivatives against six plant pathogenic fungi. A novel series of camphor‐thiazole derivatives were designed, synthesized and evaluated for their antifungal effects against Rhizoctonia solani, Fusarium graminearum, Valsa mali, Alternaria solani, Colletotrichum orbiculare and Botryitis cinerea.RESULTSMost of the synthesized camphor‐thiazole derivatives exhibited notable antifungal activity. Amongst them, compounds C5, C10 and C17 showed significant activity against R. solani with median effective concentrations (EC50) values in the range 3–4 μg mL−1, demonstrating superior antifungal efficacy to the control drug boscalid (EC50 = 1.23 μg mL−1). Structure–activity relationship and density functional theory analysis emphasized the critical role of substituent selection in optimizing the biological activity of these compounds. Moreover, preliminary mechanistic studies revealed that compound C5 induced abnormal mycelial and cellular morphology in R. solani as observed using scanning and transmission electron microscopy, and triggered the production and accumulation of reactive oxygen species. Additionally, the increased concentration of C5 resulted in enhanced cell membrane permeability.CONCLUSIONIn this study, the designed and optimized compound C5 emerged as a promising candidate for potent antifungal agents. The results demonstrate that synthesized camphor‐thiazole derivatives possess potent antifungal activity and can serve as lead compounds for further optimization in antifungal agent development. © 2024 Society of Chemical Industry. 10.1002/ps.8563 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/ps.8563 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ps_8563 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Design and synthesis of camphor‐thiazole derivatives as potent antifungal agents: structure–activity relationship and preliminary mechanistic study Peng Dai Zihua Ma Yuncong Dang Jiaxuan Huang Huizhen Xue Yafang Sun Yu‐Cheng Gu Qing Xia Weihua Zhang Pest Management Science Design and synthesis of camphor‐thiazole derivatives as potent antifungal agents: structure–activity relationship and preliminary mechanistic study Peng Dai Zihua Ma Yuncong Dang Jiaxuan Huang Huizhen Xue Yafang Sun Yu‐Cheng Gu Qing Xia Weihua Zhang Pest Management Science AbstractBACKGROUNDPlant pathogenic fungi pose a severe threat to crop yield and food security. This study aims to investigate the potential antifungal activity and mechanism of action of camphor‐thiazole derivatives against six plant pathogenic fungi. A novel series of camphor‐thiazole derivatives were designed, synthesized and evaluated for their antifungal effects against Rhizoctonia solani, Fusarium graminearum, Valsa mali, Alternaria solani, Colletotrichum orbiculare and Botryitis cinerea.RESULTSMost of the synthesized camphor‐thiazole derivatives exhibited notable antifungal activity. Amongst them, compounds C5, C10 and C17 showed significant activity against R. solani with median effective concentrations (EC50) values in the range 3–4 μg mL−1, demonstrating superior antifungal efficacy to the control drug boscalid (EC50 = 1.23 μg mL−1). Structure–activity relationship and density functional theory analysis emphasized the critical role of substituent selection in optimizing the biological activity of these compounds. Moreover, preliminary mechanistic studies revealed that compound C5 induced abnormal mycelial and cellular morphology in R. solani as observed using scanning and transmission electron microscopy, and triggered the production and accumulation of reactive oxygen species. Additionally, the increased concentration of C5 resulted in enhanced cell membrane permeability.CONCLUSIONIn this study, the designed and optimized compound C5 emerged as a promising candidate for potent antifungal agents. The results demonstrate that synthesized camphor‐thiazole derivatives possess potent antifungal activity and can serve as lead compounds for further optimization in antifungal agent development. © 2024 Society of Chemical Industry. 10.1002/ps.8563 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Design and synthesis of camphor‐thiazole derivatives as potent antifungal agents: structure–activity relationship and preliminary mechanistic study |
| topic | Pest Management Science |
| url | https://scijournals.onlinelibrary.wiley.com/doi/10.1002/ps.8563 |