Wound microenvironment‐responsive peptide hydrogel with multifunctionalities for accelerating wound healing
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Wiley Open Access
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| Natura: | Artículo Open Access |
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Wiley
2024
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| _version_ | 1867004959088705536 |
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| author | Weimiao Dong Haihong Yang Min Liu Leixia Mei Jun Han |
| author_facet | Weimiao Dong Haihong Yang Min Liu Leixia Mei Jun Han Weimiao Dong Haihong Yang Min Liu Leixia Mei Jun Han |
| collection | Wiley Open Access |
| contents | Wound microenvironment‐responsive peptide hydrogel with multifunctionalities for accelerating wound healing Weimiao Dong Haihong Yang Min Liu Leixia Mei Jun Han Journal of Peptide Science The fabrication of wound microenvironment‐responsive peptide hydrogels with hemostatic ability, antibacterial activity, and wound healing potential remains a challenge. Herein, we constructed a multifunctional dressing by inducing the self‐assembly of a peptide (Pep‐1) and water‐soluble new methylene blue (NMB) through electrostatic interaction. The self‐assembly mechanism was demonstrated using a combination of transmission electron microscopy, circular dichroism spectrum, fluorescence spectrum, Zeta potential, and rheological analysis. The Pep‐1/NMB hydrogel also exhibited a faster drug release rate in wound acidic environment. Furthermore, when Pep‐1/NMB was exposed to a 635 nm laser, its antibacterial ratios increased sharply to 95.3%, indicating remarkably improved antibacterial effects. The findings from the blood coagulation and hemostasis assay indicated that Pep‐1/NMB effectively enhanced the speed of blood clotting in vitro and efficiently controlled hemorrhage in a mouse liver hemorrhage model. Meanwhile, hemolytic and cytotoxicity evaluation revealed that the hydrogel had excellent hemocompatibility and cytocompatibility. Finally, the findings from the wound healing studies and H&E staining indicated that the Pep‐1/NMB hydrogel had a significant impact on cell migration and wound repair. The results indicated that wound microenvironment‐responsive Pep‐1/NMB hydrogel had significant potential as a highly effective wound dressing platform, offering rapid hemostasis, antibacterial, and wound healing acceleration properties. 10.1002/psc.3595 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/psc.3595 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_psc_3595 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Wound microenvironment‐responsive peptide hydrogel with multifunctionalities for accelerating wound healing Weimiao Dong Haihong Yang Min Liu Leixia Mei Jun Han Journal of Peptide Science Wound microenvironment‐responsive peptide hydrogel with multifunctionalities for accelerating wound healing Weimiao Dong Haihong Yang Min Liu Leixia Mei Jun Han Journal of Peptide Science The fabrication of wound microenvironment‐responsive peptide hydrogels with hemostatic ability, antibacterial activity, and wound healing potential remains a challenge. Herein, we constructed a multifunctional dressing by inducing the self‐assembly of a peptide (Pep‐1) and water‐soluble new methylene blue (NMB) through electrostatic interaction. The self‐assembly mechanism was demonstrated using a combination of transmission electron microscopy, circular dichroism spectrum, fluorescence spectrum, Zeta potential, and rheological analysis. The Pep‐1/NMB hydrogel also exhibited a faster drug release rate in wound acidic environment. Furthermore, when Pep‐1/NMB was exposed to a 635 nm laser, its antibacterial ratios increased sharply to 95.3%, indicating remarkably improved antibacterial effects. The findings from the blood coagulation and hemostasis assay indicated that Pep‐1/NMB effectively enhanced the speed of blood clotting in vitro and efficiently controlled hemorrhage in a mouse liver hemorrhage model. Meanwhile, hemolytic and cytotoxicity evaluation revealed that the hydrogel had excellent hemocompatibility and cytocompatibility. Finally, the findings from the wound healing studies and H&E staining indicated that the Pep‐1/NMB hydrogel had a significant impact on cell migration and wound repair. The results indicated that wound microenvironment‐responsive Pep‐1/NMB hydrogel had significant potential as a highly effective wound dressing platform, offering rapid hemostasis, antibacterial, and wound healing acceleration properties. 10.1002/psc.3595 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Wound microenvironment‐responsive peptide hydrogel with multifunctionalities for accelerating wound healing |
| topic | Journal of Peptide Science |
| url | https://onlinelibrary.wiley.com/doi/10.1002/psc.3595 |