Phage Display–Selected Peptides: Research and Clinical Applications in Cancer Imaging
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Wiley Open Access
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| Autori principali: | , , , |
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| Natura: | Artículo Open Access |
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Wiley
2025
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| _version_ | 1867010413811466240 |
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| author | Atike Nur Cimen Melis Hazal Porsuk Ozlem Kutlu Sibel Cetinel |
| author_facet | Atike Nur Cimen Melis Hazal Porsuk Ozlem Kutlu Sibel Cetinel Atike Nur Cimen Melis Hazal Porsuk Ozlem Kutlu Sibel Cetinel |
| collection | Wiley Open Access |
| contents | Phage Display–Selected Peptides: Research and Clinical Applications in Cancer Imaging Atike Nur Cimen Melis Hazal Porsuk Ozlem Kutlu Sibel Cetinel Journal of Peptide Science ABSTRACTPhage display has emerged as a groundbreaking technique for discovering novel biomolecules with significant applications in cancer diagnosis and therapy. This technique employs genetically engineered bacteriophages to display diverse libraries of peptides on their coat proteins, enabling the identification of candidates through a biopanning process targeting specific cancer markers. Biomolecules identified via phage display are widely used as molecular tools, often labeled with imaging agents or conjugated to nanoparticles for noninvasive tumor imaging. This review provides a comprehensive overview of recent advancements in phage display applications in cancer research over the past 5 years and prominent examples of clinical studies. The analysis underscores the potential of phage display to deliver diagnostic and therapeutic biomolecules, highlighting its promise for future clinical implementation in cancer imaging. 10.1002/psc.70034 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/psc.70034 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_psc_70034 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Phage Display–Selected Peptides: Research and Clinical Applications in Cancer Imaging Atike Nur Cimen Melis Hazal Porsuk Ozlem Kutlu Sibel Cetinel Journal of Peptide Science Phage Display–Selected Peptides: Research and Clinical Applications in Cancer Imaging Atike Nur Cimen Melis Hazal Porsuk Ozlem Kutlu Sibel Cetinel Journal of Peptide Science ABSTRACTPhage display has emerged as a groundbreaking technique for discovering novel biomolecules with significant applications in cancer diagnosis and therapy. This technique employs genetically engineered bacteriophages to display diverse libraries of peptides on their coat proteins, enabling the identification of candidates through a biopanning process targeting specific cancer markers. Biomolecules identified via phage display are widely used as molecular tools, often labeled with imaging agents or conjugated to nanoparticles for noninvasive tumor imaging. This review provides a comprehensive overview of recent advancements in phage display applications in cancer research over the past 5 years and prominent examples of clinical studies. The analysis underscores the potential of phage display to deliver diagnostic and therapeutic biomolecules, highlighting its promise for future clinical implementation in cancer imaging. 10.1002/psc.70034 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Phage Display–Selected Peptides: Research and Clinical Applications in Cancer Imaging |
| topic | Journal of Peptide Science |
| url | https://onlinelibrary.wiley.com/doi/10.1002/psc.70034 |