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Bibliographic Details
Main Authors:	P. Krishna, Aatif Subhan, Khushi Gupta, Avadh Biharee, Suresh Thareja
Format:	Artículo Open Access
Published:	Wiley 2025
Subjects:	Phytotherapy Research
Online Access:	https://onlinelibrary.wiley.com/doi/10.1002/ptr.70035
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Natural Products in the 21st Century: Revolutionizing Therapeutics With Flavonoids as Key Phytometabolites P. Krishna Aatif Subhan Khushi Gupta Avadh Biharee Suresh Thareja Phytotherapy Research ABSTRACTFlavonoids, distinguished by their structural diversity and broad‐spectrum activities, represent a promising class of phytochemicals with substantial therapeutic potential. Ubiquitous in plants, these polyphenolic compounds play crucial roles in pigmentation defense and are well recognized for their protective effects against cancer, metabolic, and neurodegenerative disorders. The ability of flavonoids to interact with diverse molecular targets and regulate critical signaling pathways underscores their relevance in preclinical and clinical settings. The present review critically consolidates recent advances in the therapeutic profile of flavonoids, covering their biosynthetic pathways, molecular structures, and extraction methodologies. Emphasis is given on their pharmacological effects in cancer, metabolic, microbial, respiratory, and nutraceutical applications. The mechanistic basis of their multi‐targeted actions is also discussed and supported by emerging clinical data. By outlining the current advancements, key challenges, and future perspectives, this review advocates for incorporating flavonoid‐based interventions into clinical practice and highlights their potential as effective alternatives to conventional therapies. 10.1002/ptr.70035 http://onlinelibrary.wiley.com/termsAndConditions#vor

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// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

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