Buchumschlag

Mechanism of Cucurbitacin B Targeting ZNF70 / NLRP3 Axis Against Inflammation‐Associated Colorectal Cancer

Fuente: Wiley Open Access

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Shen Cao, Yi Tai, Yuhan Wang, Jing Han, Ming Yue Li, Young Joon Surh, Yue Xing, Hong Xiang Zuo, Xuejun Jin, Juan Ma
Format:	Artículo Open Access
Veröffentlicht:	Wiley 2026
Schlagworte:	Phytotherapy Research
Online-Zugang:	Acceder al recurso
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge

Cucurbitacin B attenuates osteoarthritis development by inhibiting NLRP3 inflammasome activation and pyroptosis through activating Nrf2/HO‐1 pathway
von: Chao Lou, et al.
Veröffentlicht: (2024)

Multifaceted Therapeutic Impacts of Cucurbitacin B: Recent Evidences From Preclinical Studies
von: Meenal Sahu, et al.
Veröffentlicht: (2025)

Astragaloside IV Alleviates Colorectal Cancer Metastases by Regulating RALY / PLD2 Axis and Inhibiting Tumoral Exosome Biogenesis
von: Ling Li, et al.
Veröffentlicht: (2025)

Calycosin Targets the CYP1B1 ‐ AKT / SP1 ‐ GPX4 Axis to Modulate Ferroptosis in Colorectal Carcinogenesis
von: Lihan Bie, et al.
Veröffentlicht: (2026)

Activation of MTCH2 by Momordin Ic Prevents Colitis and Colitis‐Associated Colorectal Cancer Through Rescuing the Mitochondrial Dysfunction of Macrophage
von: Fang Xianjun, et al.
Veröffentlicht: (2026)

Cucurbitacin B modulates M2 macrophage differentiation and attenuates osteosarcoma progression via PI3K/AKT pathway
von: Hong Wu, et al.
Veröffentlicht: (2024)

Inflammatory Bowel Disease Induces Colorectal Cancer: Risk Factors, Triggering Mechanisms, and Treatment With Phyto‐Derivatives
von: Yuyu Zhang, et al.
Veröffentlicht: (2025)

Chrysophanol Attenuates Cardiac Fibrosis and Arrhythmia by Suppressing the Endoplasmic Reticulum Stress/Pyroptosis Axis and Inflammation
von: Chengyin Liu, et al.
Veröffentlicht: (2025)

New Insights of Punicalagin in Alleviating Diabetic Liver Injury: Inhibition of NEK7 ‐ NLRP3 via Modulating Mitochondrial Dynamics
von: Xiuying Tan, et al.
Veröffentlicht: (2026)

Astragali radix Against Colorectal Cancer: Network Pharmacology, Molecular Docking, and In Vitro/In Vivo Validation of PI3K ‐Akt Pathway Modulation
von: Zhaohuan Li, et al.
Veröffentlicht: (2026)

Targeting the NLRP3 Inflammasome in Atherosclerosis: Advances in Anti‐Inflammatory Therapies With Bioactive Natural Products
von: Haizhen Guo, et al.
Veröffentlicht: (2026)

Pogostone Suppresses Microglial NLRP3 Inflammasome Activation‐Promoted Remyelination Through RXRγ Regulation of Mitophagy
von: Menghan Qian, et al.
Veröffentlicht: (2026)

Higher Intake of Resveratrol Is Associated With a Lower Risk of Colorectal Cancer: A Large‐Scale Case–Control Study
von: Ke‐xin Tu, et al.
Veröffentlicht: (2025)

Phytonanomedicine: An Assessment of Therapeutic Relevance in Cancer Through Targeting Cancer‐Associated Fibroblast in Tumor Microenvironment
von: Sonali Sahoo, et al.
Veröffentlicht: (2026)

Paeoniflorin Ameliorates Alcohol‐Induced Depression via Modulating the Gut–Brain Axis and Inhibiting the NF ‐ κB / NLRP3 Inflammasome Pathway in Mice
von: Jingwei Yu, et al.
Veröffentlicht: (2026)

Mushrooms and Colorectal Cancer: Unveiling Mechanistic Insights and Therapeutic Innovations
von: Samridhi Kurl, et al.
Veröffentlicht: (2024)

Berberine Ameliorates Atrial Remodeling and Inhibits the Atrial Fibrillation of Mice via Regulating NLRP3 Inflammasome
von: Na An, et al.
Veröffentlicht: (2025)

Ferulic Acid Alleviates Traumatic Brain Injury and Gastrointestinal Disorders by Promoting Ghrelin to Regulate the Microbiota‐Brain‐Gut Axis Inflammation and Pyroptosis
von: Yawen Cai, et al.
Veröffentlicht: (2025)

Isorhyncophylline Targets PP2AC to Modulate YAP to Inhibit Endothelial Cell Inflammation
von: Lihua Wang, et al.
Veröffentlicht: (2026)

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?
von: Sara Merlo, et al.
Veröffentlicht: (2026)

Celastrol Targets Hsc70‐Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis
von: Weitong Xu, et al.
Veröffentlicht: (2026)

Targeting Programmed Cell Death in Myocardial Ischemia–Reperfusion Injury: Potential Mechanisms and Natural Medicine Treatments
von: Xiaoyu Xuan, et al.
Veröffentlicht: (2026)

Epigallocatechin‐3‐Gallate Suppresses Glioma by Targeting Integrin αvβ3/ FAK / ERK Signaling Axis and Matrix Metalloproteinases
von: Rui Sun, et al.
Veröffentlicht: (2026)

Neurological recovery and neurogenesis by curcumin sustained‐release system cross‐linked with an acellular spinal cord scaffold in rat spinal cord injury: TargetingNLRP3inflammasome pathway
von: Neda Ghaffari, et al.
Veröffentlicht: (2024)

Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload‐induced heart failure mice
von: Zhao Fang, et al.
Veröffentlicht: (2024)

Cycloastragenol Alleviates Bone Cancer Pain by Targeting Sirt1 to Inhibit Neuronal Ferroptosis and Promote M2 Microglial Polarization in the Spinal Dorsal Horn of Rats
von: Chengfei Xu, et al.
Veröffentlicht: (2026)

The Role of NLRP3 Inflammasomes in Neurological Disorders: Mechanistic Understanding and Phytochemical‐Based Therapeutics
von: Saloni Rahi, et al.
Veröffentlicht: (2026)

Non‐Apoptotic Inhibition of Colorectal Cancer Proliferation by Sclareol via Ferroptosis Involving SLC7A11/GPX4 Modulation
von: Yu‐Xi Li, et al.
Veröffentlicht: (2025)

Oncopreventive and Oncotherapeutic Potential of Plant Secondary Metabolites Against Gastric Cancer: A Review
von: Subhadas Chatterjee, et al.
Veröffentlicht: (2026)

Underlying Mechanisms of Lung Endothelial Cell Involvement in Inflammatory Immune Response in Lung Diseases and Potential Traditional Chinese Medicine: A Review
von: Liyue Ren, et al.
Veröffentlicht: (2025)

Crocin Attenuates Nrf2/ GPX4 Mediated Ferroptosis in Obstructive Nephropathy by Selectively Targeting MKK4
von: Ziyun Xu, et al.
Veröffentlicht: (2025)

Diallyl Trisulfide Suppresses Tumor‐Associated Macrophage M2 ‐Like Polarization and Recruitment and Improves the Tumor Microenvironment Through Blocking CCL5 / STAT3 Signaling Pathway Against Lung Cancer
von: Chunfeng Xie, et al.
Veröffentlicht: (2025)

Gut Microbiota and Bile Acid Metabolism in the Mechanism of Ginsenoside Re Against Nonalcoholic Fatty Liver Disease
von: Yanfang Zheng, et al.
Veröffentlicht: (2025)

Quercetin Alleviates Breast Cancer‐Related Depression by Inhibiting Neutrophil Extracellular Traps via Inhibition of Sphingosine 1‐Phosphate/Sphingosine 1‐Phosphate Receptor Axis
von: Qing Zhu, et al.
Veröffentlicht: (2025)

Ginsenoside Rb2 Attenuates Microvascular Endothelial Stress Injury by Mediating Mitochondrial Pathway Pyroptosis via the DNA ‐ PKcs ‐ SIRT5 Axis
von: Xiangyi Pu, et al.
Veröffentlicht: (2026)

New horizons for the study of saffron (Crocus sativus L.) and its active ingredients in the management of neurological and psychiatric disorders: A systematic review of clinical evidence and mechanisms
von: Shufen Han, et al.
Veröffentlicht: (2024)

Morroniside Modulates Microglia Polarization via the CX3CL1/CX3CR1/PU.1 Axis in ApoE4 Transgenic Mice
von: Ying‐Yan Chang, et al.
Veröffentlicht: (2026)

Chrysophanol Attenuates Glucocorticoid‐Induced Osteoporosis by Targeting the E74 ‐Like Factor 5/Osteoglycin‐Regulated PI3K / AKT / mTOR Signaling Axis: An In Vitro and In Vivo Study
von: Rongjin Chen, et al.
Veröffentlicht: (2026)

Phytochemicals Targeting Wnt/β‐Catenin in Osteoblasts: Mechanisms, Scaffolds, and Computational Insights for Bone Therapeutics
von: Aarti Abhishek Shah, et al.
Veröffentlicht: (2026)

The Role of Medicinal Plants in Modulating Epigenetic Mechanisms: Implications for Cancer Prevention and Therapy
von: Khadra Afaf Bendrihem, et al.
Veröffentlicht: (2025)