Synergistic Effects of Exercise and Dietary Polyphenols on Cognitive Function and Neuroprotection in Aging: A Focus on Spatial Learning and Memory
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Wiley Open Access
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| Natura: | Artículo Open Access |
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Wiley
2026
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| _version_ | 1867018616647450624 |
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| author | Rui Cheng Xuejing Yang Haiyang Su Xiangyu Wei Hongming Ji Dong Song |
| author_facet | Rui Cheng Xuejing Yang Haiyang Su Xiangyu Wei Hongming Ji Dong Song Rui Cheng Xuejing Yang Haiyang Su Xiangyu Wei Hongming Ji Dong Song |
| collection | Wiley Open Access |
| contents | Synergistic Effects of Exercise and Dietary Polyphenols on Cognitive Function and Neuroprotection in Aging: A Focus on Spatial Learning and Memory Rui Cheng Xuejing Yang Haiyang Su Xiangyu Wei Hongming Ji Dong Song Phytotherapy Research ABSTRACT This comprehensive review examines the synergistic effects of physical exercise and polyphenolic compounds, such as flavonoids, curcumin, and resveratrol, on spatial learning and memory. The interplay between these interventions highlights their potential to enhance cognitive function by promoting neurogenesis, synaptic plasticity, and resilience against oxidative stress and inflammation. Mechanistic insights reveal that exercise and polyphenols activate complementary neuroprotective pathways, including the upregulation of BDNF and CREB, as well as the modulation of antioxidant defenses via Nrf2. Evidence from both animal and human studies demonstrates significant improvements in spatial memory and hippocampal function when these strategies are combined. Despite promising findings, challenges related to bioavailability, dosing, and long‐term efficacy remain, underscoring the need for further investigation. This review emphasizes the potential clinical applications of these combined approaches for preventing cognitive decline and promoting brain health during aging and in neurodegenerative conditions. 10.1002/ptr.70341 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/ptr.70341 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ptr_70341 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Synergistic Effects of Exercise and Dietary Polyphenols on Cognitive Function and Neuroprotection in Aging: A Focus on Spatial Learning and Memory Rui Cheng Xuejing Yang Haiyang Su Xiangyu Wei Hongming Ji Dong Song Phytotherapy Research Synergistic Effects of Exercise and Dietary Polyphenols on Cognitive Function and Neuroprotection in Aging: A Focus on Spatial Learning and Memory Rui Cheng Xuejing Yang Haiyang Su Xiangyu Wei Hongming Ji Dong Song Phytotherapy Research ABSTRACT This comprehensive review examines the synergistic effects of physical exercise and polyphenolic compounds, such as flavonoids, curcumin, and resveratrol, on spatial learning and memory. The interplay between these interventions highlights their potential to enhance cognitive function by promoting neurogenesis, synaptic plasticity, and resilience against oxidative stress and inflammation. Mechanistic insights reveal that exercise and polyphenols activate complementary neuroprotective pathways, including the upregulation of BDNF and CREB, as well as the modulation of antioxidant defenses via Nrf2. Evidence from both animal and human studies demonstrates significant improvements in spatial memory and hippocampal function when these strategies are combined. Despite promising findings, challenges related to bioavailability, dosing, and long‐term efficacy remain, underscoring the need for further investigation. This review emphasizes the potential clinical applications of these combined approaches for preventing cognitive decline and promoting brain health during aging and in neurodegenerative conditions. 10.1002/ptr.70341 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Synergistic Effects of Exercise and Dietary Polyphenols on Cognitive Function and Neuroprotection in Aging: A Focus on Spatial Learning and Memory |
| topic | Phytotherapy Research |
| url | https://onlinelibrary.wiley.com/doi/10.1002/ptr.70341 |