Thonningianin A from Penthorum chinense Pursh as a targeted inhibitor of Alzheimer's disease‐related β‐amyloid and Tau proteins
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Lu Yu Huimiao Wang Qianfang Yao Keru Li Liqun Qu Bin Tang Wu Zeng Gan Qiao Yong Tang Guishan Hu Guangqiang Hu Vincent Kam‐Wai Wong Qiong Wang Dalian Qin Jianming Wu Xiaogang Zhou Xiaolei Sun Betty Yuen‐Kwan Law Anguo Wu |
| author_facet | Lu Yu Huimiao Wang Qianfang Yao Keru Li Liqun Qu Bin Tang Wu Zeng Gan Qiao Yong Tang Guishan Hu Guangqiang Hu Vincent Kam‐Wai Wong Qiong Wang Dalian Qin Jianming Wu Xiaogang Zhou Xiaolei Sun Betty Yuen‐Kwan Law Anguo Wu Lu Yu Huimiao Wang Qianfang Yao Keru Li Liqun Qu Bin Tang Wu Zeng Gan Qiao Yong Tang Guishan Hu Guangqiang Hu Vincent Kam‐Wai Wong Qiong Wang Dalian Qin Jianming Wu Xiaogang Zhou Xiaolei Sun Betty Yuen‐Kwan Law Anguo Wu |
| collection | Wiley Open Access |
| contents | Thonningianin A from Penthorum chinense Pursh as a targeted inhibitor of Alzheimer's disease‐related β‐amyloid and Tau proteins Lu Yu Huimiao Wang Qianfang Yao Keru Li Liqun Qu Bin Tang Wu Zeng Gan Qiao Yong Tang Guishan Hu Guangqiang Hu Vincent Kam‐Wai Wong Qiong Wang Dalian Qin Jianming Wu Xiaogang Zhou Xiaolei Sun Betty Yuen‐Kwan Law Anguo Wu Phytotherapy Research AbstractAlzheimer's disease (AD) is a neurodegenerative disorder characterized by complex pathogenesis mechanisms. Among these, β‐amyloid plaques and hyperphosphorylated Tau protein tangles have been identified as significant contributors to neuronal damage. This study investigates thonningianin A (TA) from Penthorum chinense Pursh (PCP) as a potential inhibitor targeting these pivotal proteins in AD progression. The inhibitory potential of PCP and TA on Aβ fibrillization was initially investigated. Subsequently, ultra‐high performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry and biolayer interferometry were employed to determine TA's affinity for both Aβ and Tau. The inhibitory effects of TA on the levels and cytotoxicity of AD‐related proteins were then assessed. In 3xTg‐AD mice, the therapeutic potential of TA was evaluated. Additionally, the molecular interactions between TA and either Aβ or Tau were explored using molecular docking. We found that PCP‐total ethanol extract and TA significantly inhibited Aβ fibrillization. Additionally, TA demonstrated strong affinity to Aβ and Tau, reduced levels of amyloid precursor protein and Tau, and alleviated mitochondrial distress in PC‐12 cells. In 3xTg‐AD mice, TA improved cognition, reduced Aβ and Tau pathology, and strengthened neurons. Moreover, molecular analyses revealed efficient binding of TA to Aβ and Tau. In conclusion, TA, derived from PCP, shows significant neuroprotection against AD proteins, highlighting its potential as an anti‐AD drug candidate. 10.1002/ptr.8060 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/ptr.8060 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ptr_8060 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Thonningianin A from Penthorum chinense Pursh as a targeted inhibitor of Alzheimer's disease‐related β‐amyloid and Tau proteins Lu Yu Huimiao Wang Qianfang Yao Keru Li Liqun Qu Bin Tang Wu Zeng Gan Qiao Yong Tang Guishan Hu Guangqiang Hu Vincent Kam‐Wai Wong Qiong Wang Dalian Qin Jianming Wu Xiaogang Zhou Xiaolei Sun Betty Yuen‐Kwan Law Anguo Wu Phytotherapy Research Thonningianin A from Penthorum chinense Pursh as a targeted inhibitor of Alzheimer's disease‐related β‐amyloid and Tau proteins Lu Yu Huimiao Wang Qianfang Yao Keru Li Liqun Qu Bin Tang Wu Zeng Gan Qiao Yong Tang Guishan Hu Guangqiang Hu Vincent Kam‐Wai Wong Qiong Wang Dalian Qin Jianming Wu Xiaogang Zhou Xiaolei Sun Betty Yuen‐Kwan Law Anguo Wu Phytotherapy Research AbstractAlzheimer's disease (AD) is a neurodegenerative disorder characterized by complex pathogenesis mechanisms. Among these, β‐amyloid plaques and hyperphosphorylated Tau protein tangles have been identified as significant contributors to neuronal damage. This study investigates thonningianin A (TA) from Penthorum chinense Pursh (PCP) as a potential inhibitor targeting these pivotal proteins in AD progression. The inhibitory potential of PCP and TA on Aβ fibrillization was initially investigated. Subsequently, ultra‐high performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry and biolayer interferometry were employed to determine TA's affinity for both Aβ and Tau. The inhibitory effects of TA on the levels and cytotoxicity of AD‐related proteins were then assessed. In 3xTg‐AD mice, the therapeutic potential of TA was evaluated. Additionally, the molecular interactions between TA and either Aβ or Tau were explored using molecular docking. We found that PCP‐total ethanol extract and TA significantly inhibited Aβ fibrillization. Additionally, TA demonstrated strong affinity to Aβ and Tau, reduced levels of amyloid precursor protein and Tau, and alleviated mitochondrial distress in PC‐12 cells. In 3xTg‐AD mice, TA improved cognition, reduced Aβ and Tau pathology, and strengthened neurons. Moreover, molecular analyses revealed efficient binding of TA to Aβ and Tau. In conclusion, TA, derived from PCP, shows significant neuroprotection against AD proteins, highlighting its potential as an anti‐AD drug candidate. 10.1002/ptr.8060 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Thonningianin A from Penthorum chinense Pursh as a targeted inhibitor of Alzheimer's disease‐related β‐amyloid and Tau proteins |
| topic | Phytotherapy Research |
| url | https://onlinelibrary.wiley.com/doi/10.1002/ptr.8060 |