Formononetin attenuates cigarette smoke‐induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways
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2024
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| _version_ | 1867003705912459264 |
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| author | Xiaomei Li Xianhan Jiang Runhao Zeng Xiujuan Lai Jing Wang Hao Liu Huihui Wu Jiaxun He Lian Liu Zhiying Zhu Jingpei Li Xue Liang |
| author_facet | Xiaomei Li Xianhan Jiang Runhao Zeng Xiujuan Lai Jing Wang Hao Liu Huihui Wu Jiaxun He Lian Liu Zhiying Zhu Jingpei Li Xue Liang Xiaomei Li Xianhan Jiang Runhao Zeng Xiujuan Lai Jing Wang Hao Liu Huihui Wu Jiaxun He Lian Liu Zhiying Zhu Jingpei Li Xue Liang |
| collection | Wiley Open Access |
| contents | Formononetin attenuates cigarette smoke‐induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways Xiaomei Li Xianhan Jiang Runhao Zeng Xiujuan Lai Jing Wang Hao Liu Huihui Wu Jiaxun He Lian Liu Zhiying Zhu Jingpei Li Xue Liang Phytotherapy Research AbstractChronic obstructive pulmonary disease (COPD) is a chronic, progressive, and lethal lung disease with few treatments. Formononetin (FMN) is a clinical preparation extract with extensive pharmacological actions. However, its effect on COPD remains unknown. This study aimed to explore the effect and underlying mechanisms of FMN on COPD. A mouse model of COPD was established by exposure to cigarette smoke (CS) for 24 weeks. In addition, bronchial epithelial BEAS‐2B cells were treated with CS extract (CSE) for 24 h to explore the in vitro effect of FMN. FMN significantly improved lung function and attenuated pathological lung damage. FMN treatment reduced inflammatory cell infiltration and pro‐inflammatory cytokines secretion. FMN also suppressed apoptosis by regulating apoptosis‐associated proteins. Moreover, FMN relieved CS‐induced endoplasmic reticulum (ER) stress in the mouse lungs. In BEAS‐2B cells, FMN treatment reduced CSE‐induced inflammation, ER stress, and apoptosis. Mechanistically, FMN downregulated the CS‐activated AhR/CYP1A1 and AKT/mTOR signaling pathways in vivo and in vitro. FMN can attenuate CS‐induced COPD in mice by suppressing inflammation, ER stress, and apoptosis in bronchial epithelial cells via the inhibition of AhR/CYP1A1 and AKT/mTOR signaling pathways, suggesting a new therapeutic potential for COPD treatment. 10.1002/ptr.8104 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/ptr.8104 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ptr_8104 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Formononetin attenuates cigarette smoke‐induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways Xiaomei Li Xianhan Jiang Runhao Zeng Xiujuan Lai Jing Wang Hao Liu Huihui Wu Jiaxun He Lian Liu Zhiying Zhu Jingpei Li Xue Liang Phytotherapy Research Formononetin attenuates cigarette smoke‐induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways Xiaomei Li Xianhan Jiang Runhao Zeng Xiujuan Lai Jing Wang Hao Liu Huihui Wu Jiaxun He Lian Liu Zhiying Zhu Jingpei Li Xue Liang Phytotherapy Research AbstractChronic obstructive pulmonary disease (COPD) is a chronic, progressive, and lethal lung disease with few treatments. Formononetin (FMN) is a clinical preparation extract with extensive pharmacological actions. However, its effect on COPD remains unknown. This study aimed to explore the effect and underlying mechanisms of FMN on COPD. A mouse model of COPD was established by exposure to cigarette smoke (CS) for 24 weeks. In addition, bronchial epithelial BEAS‐2B cells were treated with CS extract (CSE) for 24 h to explore the in vitro effect of FMN. FMN significantly improved lung function and attenuated pathological lung damage. FMN treatment reduced inflammatory cell infiltration and pro‐inflammatory cytokines secretion. FMN also suppressed apoptosis by regulating apoptosis‐associated proteins. Moreover, FMN relieved CS‐induced endoplasmic reticulum (ER) stress in the mouse lungs. In BEAS‐2B cells, FMN treatment reduced CSE‐induced inflammation, ER stress, and apoptosis. Mechanistically, FMN downregulated the CS‐activated AhR/CYP1A1 and AKT/mTOR signaling pathways in vivo and in vitro. FMN can attenuate CS‐induced COPD in mice by suppressing inflammation, ER stress, and apoptosis in bronchial epithelial cells via the inhibition of AhR/CYP1A1 and AKT/mTOR signaling pathways, suggesting a new therapeutic potential for COPD treatment. 10.1002/ptr.8104 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Formononetin attenuates cigarette smoke‐induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways |
| topic | Phytotherapy Research |
| url | https://onlinelibrary.wiley.com/doi/10.1002/ptr.8104 |