Cucurbitacin B modulates M2 macrophage differentiation and attenuates osteosarcoma progression via PI3K/AKT pathway
Fuente:
Wiley Open Access
Saved in:
| Main Authors: | Hong Wu, Tianjun Ma, Mei He, Wenkai Xie, Xueyan Wang, Liuping Lu, Hui Wang, Ying Cui |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2024
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
Cucurbitacin B attenuates osteoarthritis development by inhibiting NLRP3 inflammasome activation and pyroptosis through activating Nrf2/HO‐1 pathway
by: Chao Lou, et al.
Published: (2024)
by: Chao Lou, et al.
Published: (2024)
Quercetin prevented diabetic nephropathy by inhibiting renal tubular epithelial cell apoptosis via the PI3K/AKT pathway
by: Fang Liu, et al.
Published: (2024)
by: Fang Liu, et al.
Published: (2024)
Oxyimperatorin Suppresses the Pathologies of Rheumatoid Arthritis and the Growth of Synovial Organoids Through Targeting the PI3K / AKT Pathway
by: Xu Gao, et al.
Published: (2025)
by: Xu Gao, et al.
Published: (2025)
Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF‐kappaB signaling pathway: In vitro and in vivo studies
by: Ziyang Ye, et al.
Published: (2024)
by: Ziyang Ye, et al.
Published: (2024)
Mechanism of Cucurbitacin B Targeting ZNF70 / NLRP3 Axis Against Inflammation‐Associated Colorectal Cancer
by: Shen Cao, et al.
Published: (2026)
by: Shen Cao, et al.
Published: (2026)
Asiatic Acid Ameliorates MNNG ‐Induced Chronic Atrophic Gastritis by Inhibiting the Activation of the HRAS / PI3K / AKT / GSK3β Signaling Axis
by: Feifei Zhou, et al.
Published: (2026)
by: Feifei Zhou, et al.
Published: (2026)
Multifaceted Therapeutic Impacts of Cucurbitacin B: Recent Evidences From Preclinical Studies
by: Meenal Sahu, et al.
Published: (2025)
by: Meenal Sahu, et al.
Published: (2025)
Hydroxytyrosol Improves UV ‐Induced Skin Photoaging via PI3K ‐ AKT / MAPK / JAK ‐ STAT and NF ‐ κB Pathways: Insights From Keratinocytes and In Vivo Validation
by: Enhui Wang, et al.
Published: (2026)
by: Enhui Wang, et al.
Published: (2026)
Isoalantolactone exerts anti‐melanoma effects via inhibiting PI3K/AKT/mTOR and STAT3 signaling in cell and mouse models
by: Jun‐Kui Li, et al.
Published: (2024)
by: Jun‐Kui Li, et al.
Published: (2024)
Formononetin attenuates cigarette smoke‐induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways
by: Xiaomei Li, et al.
Published: (2024)
by: Xiaomei Li, et al.
Published: (2024)
Sulforaphane Attenuates PM 2.5 ‐Induced Chronic Obstructive Pulmonary Disease by Modulation of Nrf2 Activating and EGFR / PI3K / AKT Signaling
by: Qi Lin, et al.
Published: (2026)
by: Qi Lin, et al.
Published: (2026)
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2 / STAT3 and PI3K / AKT Pathways
by: Qixuan Zhang, et al.
Published: (2025)
by: Qixuan Zhang, et al.
Published: (2025)
Geniposide Improves Glycolysis Driven Angiogenesis in Experimentary Arthritis by Inhibiting SphK1 ‐ PI3K ‐Akt‐ PFKFB3 Signal
by: Yanhong Bu, et al.
Published: (2025)
by: Yanhong Bu, et al.
Published: (2025)
Natural xanthones as modulators of the Nrf2/ARE signaling pathway and potential gastroprotective agents
by: Natalie Vivien Gunter, et al.
Published: (2024)
by: Natalie Vivien Gunter, et al.
Published: (2024)
Chrysophanol Attenuates Glucocorticoid‐Induced Osteoporosis by Targeting the E74 ‐Like Factor 5/Osteoglycin‐Regulated PI3K / AKT / mTOR Signaling Axis: An In Vitro and In Vivo Study
by: Rongjin Chen, et al.
Published: (2026)
by: Rongjin Chen, et al.
Published: (2026)
Geniposide modulates GSK3β to inhibit Th17 differentiation and mitigate endothelial damage in intracranial aneurysm
by: Qian Zhang, et al.
Published: (2024)
by: Qian Zhang, et al.
Published: (2024)
Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K/Akt/mTOR signaling pathway
by: Amin Iranpanah, et al.
Published: (2024)
by: Amin Iranpanah, et al.
Published: (2024)
Phytoconstituents as modulator of inflammatory pathways for COVID‐19: A comprehensive review and recommendations
by: Pragati Gupta, et al.
Published: (2024)
by: Pragati Gupta, et al.
Published: (2024)
Columbianadin Ameliorates Myocardial Injury by Inhibiting Autophagy Through the PI3K/Akt/mTOR Signaling Pathway in AMI Mice and Hypoxic H9c2 Cells
by: Niu Zi‐Chang, et al.
Published: (2024)
by: Niu Zi‐Chang, et al.
Published: (2024)
Mechanism Study on Liquiritin Alleviating Nociceptive Sensitization in Knee Osteoarthritis via Promoting M2 Macrophage Polarization Through Regulation of the Rap1/ PI3K /Akt Signaling Pathway
by: Hou‐Yu Fu, et al.
Published: (2026)
by: Hou‐Yu Fu, et al.
Published: (2026)
20(R)‐ginsenoside Rg3 attenuates cerebral ischemia–reperfusion injury by mitigating mitochondrial oxidative stress via the Nrf2/HO‐1 signaling pathway
by: Deyun Chen, et al.
Published: (2024)
by: Deyun Chen, et al.
Published: (2024)
Diallyl disulfide, the bioactive component of Allium species, ameliorates pulmonary fibrosis by mediating the crosstalk of farnesoid X receptor and yes‐associated protein 1 signaling pathway
by: Jia‐yi Dou, et al.
Published: (2024)
by: Jia‐yi Dou, et al.
Published: (2024)
Resveratrol triggers autophagy‐related apoptosis to inhibit the progression of colorectal cancer via inhibition of FOXQ1
by: MinFeng Zhou, et al.
Published: (2024)
by: MinFeng Zhou, et al.
Published: (2024)
Astragali radix Against Colorectal Cancer: Network Pharmacology, Molecular Docking, and In Vitro/In Vivo Validation of PI3K ‐Akt Pathway Modulation
by: Zhaohuan Li, et al.
Published: (2026)
by: Zhaohuan Li, et al.
Published: (2026)
Calycosin Targets the CYP1B1 ‐ AKT / SP1 ‐ GPX4 Axis to Modulate Ferroptosis in Colorectal Carcinogenesis
by: Lihan Bie, et al.
Published: (2026)
by: Lihan Bie, et al.
Published: (2026)
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT‐mTOR‐TFEB Signaling Pathway
by: Yuxuan Zhu, et al.
Published: (2025)
by: Yuxuan Zhu, et al.
Published: (2025)
Toosendanin Induces Cell Cycle Arrest and Apoptosis to Suppress Diffuse Large B‐Cell Lymphoma Growth by Inhibiting PI3Kα/β and PLK1 Signaling
by: Qian Hu, et al.
Published: (2025)
by: Qian Hu, et al.
Published: (2025)
Magnoflorine alleviates dextran sulfate sodium‐induced ulcerative colitis via inhibiting JAK2/STAT3 signaling pathway
by: Jianxia Wen, et al.
Published: (2024)
by: Jianxia Wen, et al.
Published: (2024)
Panax ginseng C. A. Mey. Targeting Pyroptosis for Treatment of Diabetes Related Metabolic Diseases: A Review of Potential Therapeutic Strategies
by: Meng Sun, et al.
Published: (2025)
by: Meng Sun, et al.
Published: (2025)
Morroniside Modulates Microglia Polarization via the CX3CL1/CX3CR1/PU.1 Axis in ApoE4 Transgenic Mice
by: Ying‐Yan Chang, et al.
Published: (2026)
by: Ying‐Yan Chang, et al.
Published: (2026)
Harmine promotes megakaryocyte differentiation and thrombopoiesis by activating the Rac1/Cdc42/JNK pathway through a potential target of 5‐HTR2A
by: Xiaoxi Liu, et al.
Published: (2024)
by: Xiaoxi Liu, et al.
Published: (2024)
Exploring the therapeutic implications of natural compounds modulating apoptosis in vascular dementia
by: Guangcheng Zhong, et al.
Published: (2024)
by: Guangcheng Zhong, et al.
Published: (2024)
Motor behavior induced by bergamot essential oil in experimental tasks is differentially modulated by pretreatment with metabotropic glutamate receptor 2/3 or 5 antagonists
by: Laura Rombolà, et al.
Published: (2024)
by: Laura Rombolà, et al.
Published: (2024)
D‐pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin‐mediated endoplasmic reticulum stress and glycophagy signaling pathway
by: Xiaoli Li, et al.
Published: (2024)
by: Xiaoli Li, et al.
Published: (2024)
Hypoglycemic Effect of Ginsenoside Compound K Mediated by N‐Acetylserotonin Derived From Gut Microbiota
by: Su‐Tian‐Zi Huang, et al.
Published: (2025)
by: Su‐Tian‐Zi Huang, et al.
Published: (2025)
Correction to: Sclareol attenuates angiotensin II‐induced cardiac remodeling and inflammation via inhibiting MAPK signaling
by: Na Yang, et al.
Published: (2024)
by: Na Yang, et al.
Published: (2024)
A novel treatment strategy targeting cellular pathways with natural products to alleviate sarcopenia
by: Da Hee Lee, et al.
Published: (2024)
by: Da Hee Lee, et al.
Published: (2024)
Modulating the BI ‐1( TMBIM6 )/ AKT Signaling Pathway by Licochalcone D Treatment Inhibits Human Melanoma Cell Growth
by: Sun‐Young Hwang, et al.
Published: (2025)
by: Sun‐Young Hwang, et al.
Published: (2025)
Chinese Herbal Medicine and Their Active Ingredients Involved in the Treatment of Atopic Dermatitis Related Signaling Pathways
by: Wenkai Nie, et al.
Published: (2025)
by: Wenkai Nie, et al.
Published: (2025)
Sanguinarine Induces ROS ‐Mediated Mitochondrial Dysfunction and Inhibits AKT / GSK3 Signaling to Potentiate Apoptotic Effects in Cutaneous T‐Cell Lymphoma
by: Shilpa Kuttikrishnan, et al.
Published: (2026)
by: Shilpa Kuttikrishnan, et al.
Published: (2026)
Similar Items
-
Cucurbitacin B attenuates osteoarthritis development by inhibiting NLRP3 inflammasome activation and pyroptosis through activating Nrf2/HO‐1 pathway
by: Chao Lou, et al.
Published: (2024) -
Quercetin prevented diabetic nephropathy by inhibiting renal tubular epithelial cell apoptosis via the PI3K/AKT pathway
by: Fang Liu, et al.
Published: (2024) -
Oxyimperatorin Suppresses the Pathologies of Rheumatoid Arthritis and the Growth of Synovial Organoids Through Targeting the PI3K / AKT Pathway
by: Xu Gao, et al.
Published: (2025) -
Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF‐kappaB signaling pathway: In vitro and in vivo studies
by: Ziyang Ye, et al.
Published: (2024) -
Mechanism of Cucurbitacin B Targeting ZNF70 / NLRP3 Axis Against Inflammation‐Associated Colorectal Cancer
by: Shen Cao, et al.
Published: (2026)