Insights into the anti‐Candida albicans properties of natural phytochemicals: An in vitro and in vivo investigation
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Daifan Yue Dongming Zheng Yuxin Bai Linlan Yang Jiangyan Yong Yan Li |
| author_facet | Daifan Yue Dongming Zheng Yuxin Bai Linlan Yang Jiangyan Yong Yan Li Daifan Yue Dongming Zheng Yuxin Bai Linlan Yang Jiangyan Yong Yan Li |
| collection | Wiley Open Access |
| contents | Insights into the anti‐Candida albicans properties of natural phytochemicals: An in vitro and in vivo investigation Daifan Yue Dongming Zheng Yuxin Bai Linlan Yang Jiangyan Yong Yan Li Phytotherapy Research AbstractInvasive candidiasis, attributed to Candida albicans, has long been a formidable threat to human health. Despite the advent of effective therapeutics in recent decades, the mortality rate in affected patient populations remains discouraging. This is exacerbated by the emergence of multidrug resistance, significantly limiting the utility of conventional antifungals. Consequently, researchers are compelled to continuously explore novel solutions. Natural phytochemicals present a potential adjunct to the existing arsenal of agents. Previous studies have substantiated the efficacy of phytochemicals against C. albicans. Emerging evidence also underscores the promising application of phytochemicals in the realm of antifungal treatment. This review systematically delineates the inhibitory activity of phytochemicals, both in monotherapy and combination therapy, against C. albicans in both in vivo and in vitro settings. Moreover, it elucidates the mechanisms underpinning the antifungal properties, encompassing (i) cell wall and plasma membrane damage, (ii) inhibition of efflux pumps, (iii) induction of mitochondrial dysfunction, and (iv) inhibition of virulence factors. Subsequently, the review introduces the substantial potential of nanotechnology and photodynamic technology in enhancing the bioavailability of phytochemicals. Lastly, it discusses current limitations and outlines future research priorities, emphasizing the need for high‐quality research to comprehensively establish the clinical efficacy and safety of phytochemicals in treating fungal infections. This review aims to inspire further contemplation and recommendations for the effective integration of natural phytochemicals in the development of new medicines for patients afflicted with C. albicans. 10.1002/ptr.8148 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/ptr.8148 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ptr_8148 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Insights into the anti‐Candida albicans properties of natural phytochemicals: An in vitro and in vivo investigation Daifan Yue Dongming Zheng Yuxin Bai Linlan Yang Jiangyan Yong Yan Li Phytotherapy Research Insights into the anti‐Candida albicans properties of natural phytochemicals: An in vitro and in vivo investigation Daifan Yue Dongming Zheng Yuxin Bai Linlan Yang Jiangyan Yong Yan Li Phytotherapy Research AbstractInvasive candidiasis, attributed to Candida albicans, has long been a formidable threat to human health. Despite the advent of effective therapeutics in recent decades, the mortality rate in affected patient populations remains discouraging. This is exacerbated by the emergence of multidrug resistance, significantly limiting the utility of conventional antifungals. Consequently, researchers are compelled to continuously explore novel solutions. Natural phytochemicals present a potential adjunct to the existing arsenal of agents. Previous studies have substantiated the efficacy of phytochemicals against C. albicans. Emerging evidence also underscores the promising application of phytochemicals in the realm of antifungal treatment. This review systematically delineates the inhibitory activity of phytochemicals, both in monotherapy and combination therapy, against C. albicans in both in vivo and in vitro settings. Moreover, it elucidates the mechanisms underpinning the antifungal properties, encompassing (i) cell wall and plasma membrane damage, (ii) inhibition of efflux pumps, (iii) induction of mitochondrial dysfunction, and (iv) inhibition of virulence factors. Subsequently, the review introduces the substantial potential of nanotechnology and photodynamic technology in enhancing the bioavailability of phytochemicals. Lastly, it discusses current limitations and outlines future research priorities, emphasizing the need for high‐quality research to comprehensively establish the clinical efficacy and safety of phytochemicals in treating fungal infections. This review aims to inspire further contemplation and recommendations for the effective integration of natural phytochemicals in the development of new medicines for patients afflicted with C. albicans. 10.1002/ptr.8148 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Insights into the anti‐Candida albicans properties of natural phytochemicals: An in vitro and in vivo investigation |
| topic | Phytotherapy Research |
| url | https://onlinelibrary.wiley.com/doi/10.1002/ptr.8148 |