Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance
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2024
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| author | Vivek P. Chavda Amit Z. Chaudhari Pankti C. Balar Amol Gholap Lalitkumar K. Vora |
| author_facet | Vivek P. Chavda Amit Z. Chaudhari Pankti C. Balar Amol Gholap Lalitkumar K. Vora Vivek P. Chavda Amit Z. Chaudhari Pankti C. Balar Amol Gholap Lalitkumar K. Vora |
| collection | Wiley Open Access |
| contents | Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance Vivek P. Chavda Amit Z. Chaudhari Pankti C. Balar Amol Gholap Lalitkumar K. Vora Phytotherapy Research AbstractPhytoestrogens, also known as xenoestrogens, are secondary metabolites derived from plants that have similar structures and biological effects as human estrogens. These compounds do not directly affect biological functions but can act as agonists or antagonists depending on the level of endogenous estrogen in the body. Phytoestrogens may have an epigenetic mechanism of action independent of estrogen receptors. These compounds are found in more than 300 plant species and are synthesized through the phenylpropanoid pathway, with specific enzymes leading to various chemical structures. Phytoestrogens, primarily phenolic compounds, include isoflavonoids, flavonoids, stilbenes, and lignans. Extensive research in animals and humans has demonstrated the protective effects of phytoestrogens on estrogen‐dependent diseases. Clinical trials have also shown their potential benefits in conditions such as osteoporosis, Parkinson's disease, and certain types of cancer. This review provides a concise overview of phytoestrogen classification, chemical diversity, and biosynthesis and discusses the potential therapeutic effects of phytoestrogens, as well as their preclinical and clinical development. 10.1002/ptr.8196 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/ptr.8196 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ptr_8196 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance Vivek P. Chavda Amit Z. Chaudhari Pankti C. Balar Amol Gholap Lalitkumar K. Vora Phytotherapy Research Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance Vivek P. Chavda Amit Z. Chaudhari Pankti C. Balar Amol Gholap Lalitkumar K. Vora Phytotherapy Research AbstractPhytoestrogens, also known as xenoestrogens, are secondary metabolites derived from plants that have similar structures and biological effects as human estrogens. These compounds do not directly affect biological functions but can act as agonists or antagonists depending on the level of endogenous estrogen in the body. Phytoestrogens may have an epigenetic mechanism of action independent of estrogen receptors. These compounds are found in more than 300 plant species and are synthesized through the phenylpropanoid pathway, with specific enzymes leading to various chemical structures. Phytoestrogens, primarily phenolic compounds, include isoflavonoids, flavonoids, stilbenes, and lignans. Extensive research in animals and humans has demonstrated the protective effects of phytoestrogens on estrogen‐dependent diseases. Clinical trials have also shown their potential benefits in conditions such as osteoporosis, Parkinson's disease, and certain types of cancer. This review provides a concise overview of phytoestrogen classification, chemical diversity, and biosynthesis and discusses the potential therapeutic effects of phytoestrogens, as well as their preclinical and clinical development. 10.1002/ptr.8196 http://creativecommons.org/licenses/by/4.0/ |
| title | Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance |
| topic | Phytotherapy Research |
| url | https://onlinelibrary.wiley.com/doi/10.1002/ptr.8196 |