Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies
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2024
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| author | Mengjie Wang Zhiyuan Wang Zhichao Li Yuan Qu Jiting Zhao Lei Wang Xinpeng Zhou Ziqi Xu Di Zhang Ping Jiang Bing Fan Ying Liu |
| author_facet | Mengjie Wang Zhiyuan Wang Zhichao Li Yuan Qu Jiting Zhao Lei Wang Xinpeng Zhou Ziqi Xu Di Zhang Ping Jiang Bing Fan Ying Liu Mengjie Wang Zhiyuan Wang Zhichao Li Yuan Qu Jiting Zhao Lei Wang Xinpeng Zhou Ziqi Xu Di Zhang Ping Jiang Bing Fan Ying Liu |
| collection | Wiley Open Access |
| contents | Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies Mengjie Wang Zhiyuan Wang Zhichao Li Yuan Qu Jiting Zhao Lei Wang Xinpeng Zhou Ziqi Xu Di Zhang Ping Jiang Bing Fan Ying Liu Phytotherapy Research AbstractInflammatory bowel disease (IBD) is an autoimmune disorder primarily characterized by intestinal inflammation and recurrent ulceration, leading to a compromised intestinal barrier and inflammatory infiltration. This disorder's pathogenesis is mainly attributed to extensive damage or death of intestinal epithelial cells, along with abnormal activation or impaired death regulation of immune cells and the release of various inflammatory factors, which contribute to the inflammatory environment in the intestines. Thus, maintaining intestinal homeostasis hinges on balancing the survival and functionality of various cell types. Programmed cell death (PCD) pathways, including apoptosis, pyroptosis, autophagy, ferroptosis, necroptosis, and neutrophil extracellular traps, are integral in the pathogenesis of IBD by mediating the death of intestinal epithelial and immune cells. Natural products derived from plants, fruits, and vegetables have shown potential in regulating PCD, offering preventive and therapeutic avenues for IBD. This article reviews the role of natural products in IBD treatment by focusing on targeting PCD pathways, opening new avenues for clinical IBD management. 10.1002/ptr.8216 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/ptr.8216 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ptr_8216 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies Mengjie Wang Zhiyuan Wang Zhichao Li Yuan Qu Jiting Zhao Lei Wang Xinpeng Zhou Ziqi Xu Di Zhang Ping Jiang Bing Fan Ying Liu Phytotherapy Research Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies Mengjie Wang Zhiyuan Wang Zhichao Li Yuan Qu Jiting Zhao Lei Wang Xinpeng Zhou Ziqi Xu Di Zhang Ping Jiang Bing Fan Ying Liu Phytotherapy Research AbstractInflammatory bowel disease (IBD) is an autoimmune disorder primarily characterized by intestinal inflammation and recurrent ulceration, leading to a compromised intestinal barrier and inflammatory infiltration. This disorder's pathogenesis is mainly attributed to extensive damage or death of intestinal epithelial cells, along with abnormal activation or impaired death regulation of immune cells and the release of various inflammatory factors, which contribute to the inflammatory environment in the intestines. Thus, maintaining intestinal homeostasis hinges on balancing the survival and functionality of various cell types. Programmed cell death (PCD) pathways, including apoptosis, pyroptosis, autophagy, ferroptosis, necroptosis, and neutrophil extracellular traps, are integral in the pathogenesis of IBD by mediating the death of intestinal epithelial and immune cells. Natural products derived from plants, fruits, and vegetables have shown potential in regulating PCD, offering preventive and therapeutic avenues for IBD. This article reviews the role of natural products in IBD treatment by focusing on targeting PCD pathways, opening new avenues for clinical IBD management. 10.1002/ptr.8216 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies |
| topic | Phytotherapy Research |
| url | https://onlinelibrary.wiley.com/doi/10.1002/ptr.8216 |